• Product NameRecombinant human IGF1R
• Host SpeciesHEK293
• Purification> 95% by Tris-Bis PAGE;> 95% by SEC-HPLC
• Biological ActivityMeasured by its ability to bind human IGF-I R/IGF1R in a functional ELISA.
• Endotoxin< 1 EU/μg of the protein by LAL method.
• Immunogen DescriptionGlu31-Leu936
• Target NameIGF1R
• Alternative Names    CD221 antigen; CD221; EC 2.7.10; EC 2.7.10.1; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGF-IR; IGFR; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor
• Accession No. Uniprot:P08069
  Gene ID:3480
• UniprotP08069
• Gene ID3480
• Target Species human
• Calculated MW 80 KDa
• Tag Info C-Prescission-Twin Strep II-8xHis
• Formulation 0.22 μm filtered solution of PBS, pH 7.4.
• Reconstitution 0.2 mg/mL in sterile PBS, pH7.4
• Storage Aliquot and store at -80˚C. Avoid repeated freeze/thaw cycles.

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGF-I and II have been shown to be mediated via IGF-I R.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting