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GSK3α/β(Ab-279/216) Antibody

21301
Review: comment rank 5 pdf
  Catalog No. Package Size Price
21301-1 50ul $189.00
21301-2 100ul $279.00

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Description
  • Product Name GSK3α/β(Ab-279/216) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of total GSK3α/β protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.277~281/214~218 (V-S-Y-I-C) derived from Human GSK3α/β.
  • Target Name GSK3α/β
  • Alternative Names Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta
  • Accession No. Swiss-Prot: P49840/P49841
    NCBI Protein: NP_063937.2/NP_001139628.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 46, 51kd
Western blotting: 1:500~1:1000

Images
  • GSK3α/β(Ab-279/216) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from HL60, HT29 and 293 cells using GSK3α/β(Ab-279/216) Antibody #21301.

Background

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201
Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415
Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436
Liao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222

    Please let us know if you have published research using #21301 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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