Product Detail
Product NameSurvivin Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAffinity chromatography purified via peptide column
ApplicationsELISA WB IHC
Species ReactivityMs
Immunogen TypePeptide
Immunogen DescRaised against a synthetic peptide corresponding to amino acids near the carboxy terminus of mouse Survivin.
Target NameSurvivin
ConjugateUnconjugated
Other NamesTIAP
Accession NoSwiss-Prot:O15392
Gene ID:332
Uniprot
O15392
Gene ID
332;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Predicted MW: 17 kd
Western blot analysis of survivin in mouse spleen tissue lysate with survivin antibody at 1 ug/mL.
Immunohistochemistry of Survivin in mouse spleen cells with Survivin antibody at 10 #956;g/ml.
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.
If you have published an article using product 24094, please notify us so that we can cite your literature.
et al,Eurycomalactone switched hepatocellular carcinoma cells into quiescence through 5'tRFAla/DVL/β-catenin pathway inhibition.
, (2025),
PMID:
40128187
Yes
