Product Detail
Product NameARG1 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were purified by affinity purification using immunogen.
ApplicationsWB,IHC,IF
Species ReactivityHuman,Mouse,Rat
SpecificityThe antibody detects endogenous level of total ARG1 protein.
Immunogen TypeRecombinant Protein
Immunogen DescRecombinant protein of human ARG1.
Target NameARG1
ConjugateUnconjugated
Other NamesARG1; Arginase-1; Liver-typearginase; TypeIarginase;
Accession NoSwiss-Prot:P05089
NCBI Gene ID:383
Uniprot
P05089
Gene ID
383;
Sdspage MW35KD
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunofluorescence analysis of Rat liver using ARG1 / Arginase 1 at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of Human liver using ARG1 / Arginase 1 at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of Mouse liver using ARG1 / Arginase 1 at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using ARG1 / Arginase 1 at 1:2000 dilution.
Immunohistochemistry of paraffin-embedded mouse liver using ARG1 / Arginase 1 at dilution of 1:100 (40x lens).
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
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et al, Microbial metabolite butyrate facilitates M2 macrophage polarization and function.In Sci Rep on 2016 Apr 20 by Jian Ji , Dingming Shu et al ..PMID: 27094081
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39491609
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