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TFRC Antibody#33101

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Product Detail

Product NameTFRC Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were purified by affinity purification using immunogen.

ApplicationsWB IHC IF

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of total TFRC protein.

Immunogen TypeRecombinant Protein

Immunogen DescRecombinant protein of human TFRC.

Target NameTFRC

ConjugateUnconjugated

Other NamesT9; TR; TFR; p90; CD71

Accession NoSwiss-Prot:P02786
NCBI Gene ID:7037

Uniprot P02786

Gene ID 7037;

Sdspage MW84KD

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20˚C

Application Details

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200

Western blot analysis of extracts of various cell lines, using TFRC antibody at 1:3000 dilution.
Immunofluorescence analysis of L929 cells using TFRC Polyclonal antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat kidney using TFRC antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver cancer using TFRC antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human colon carcinoma using TFRC antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human placenta using TFRC antibody at dilution of 1:100 (40x lens).

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

If you have published an article using product 33101, please notify us so that we can cite your literature.

et al,PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration. , (2025),
PMID: 39893206

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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