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ACSL4 Antibody#36176

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Product Detail

Product NameACSL4 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntigen affinity purification.

ApplicationsWB IHC

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous levels of total ACSL4 protein.

Immunogen TypeRecombinant Protein

Immunogen DescFusion protein corresponding to residues near the C terminal of human acyl-CoA synthetase long-chain family member 4

Target NameACSL4

ConjugateUnconjugated

Other NamesACS4; FACL4; LACS4; MRX63; MRX68

Accession NoSwiss-Prot#: O60488
NCBI Gene ID: 2182
Gene Accssion: BC034959

Uniprot O60488

Gene ID 2182;

Sdspage MW79kd

Concentration0.9mg/ml

FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

StorageStore at -20˚C

Application Details

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:25-1:100

Gel: 8%SDS-PAGE
Lysates (from left to right): Hepg2, hela and 293T cell, human fetal kidney tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/225 dilution
Secondary antibody dilution: 1/8000
Exposure time: 15 seconds
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #36176 at dilution 1/25.

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.

If you have published an article using product 36176, please notify us so that we can cite your literature.

et al,PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration. , (2025),
PMID: 39893206

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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