Product Detail
Product NameNPHS1 antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IF
Species ReactivityMouse,Rat
SpecificityThe antibody detects endogenous level of total NPHS1 protein.
Immunogen TypePeptide
Immunogen DescA synthetic peptide of human NPHS1
Target NameNPHS1
ConjugateUnconjugated
Other NamesNPHS1;CNF;NPHN;nephrin
Accession NoUniprot:O60500
GeneID:4868
Uniprot
O60500
Gene ID
4868
Sdspage MW130kDa
Concentration1.0mg/ml
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of mouse kidney, using NPHS1 antibody.
Western blot analysis of extracts of various cell lines, using NPHS1 antibody.
Immunofluorescence analysis of mouse kidney cells using NPHS1 antibody.
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
If you have published an article using product 38552, please notify us so that we can cite your literature.
et al,Chronic high glucose causes podocyte epithelial-mesenchymal transition through lactate-induced histone lactylation
, (2022),
PMID:
et al,Lactate-triggered histone lactylation contributes to podocyte epithelial-mesenchymal transition in diabetic nephropathy in mice.
, (2025),
PMID:
39922521
The lead time is currently 2 weeks.
