• Product NameSMG8 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total SMG8 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthetic peptide corresponding to a region derived from internal residues of human SMG8 nonsense mediated mRNA decay factor
• Target NameSMG8
• Alternative Names    C17orf71
• Accession No. Swiss-Prot#: Q8ND04
  NCBI Gene ID: 55181
  Gene Accssion: NP_060619
• UniprotQ8ND04
• Gene ID55181;
• Concentration 1.8mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• Immunohistochemistry: 1:25-1:100

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

• Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using #37142 at dilution 1/50.
• Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #37142 at dilution 1/50.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting