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Dacogen

S1508
Review: comment rank 5 pdf
  Catalog No. Package Size Price
S1508-1 10mg $57.00
S1508-2 50mg $91.00
S1508-3 100mg $128.00
S1508-4 200mg $180.00

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Description
  • Product Name Dacogen
  • Brief Description Inhibitors
  • Purification 99.00%
  • Biological Activity Decitabine is indicated for treatment of patients with myelodysplastic syndrome (MDS). It is a chemical analogue of cytidine, a nucleoside present in DNA and RNA. Cells in the presence of Decitabine incorporate it into DNA during replication and RNA during transcription. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate.
  • Target Name DNA Methyltransferase inhibitor
  • CAS No. 2353-33-5
  • Calculated MW 228.21
  • Formulation C8H12N4O4
  • Storage 3 years -20˚C powder;2 years -80˚C in solvent;
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  • Dacogen - SAB | Signalway Antibody


Product Description

Research Area:Cancer
SMILES:C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O
Pathways:Chromatin/Epigenetic
Receptor:DNA methyltransferase (DNMT)
Boling pt:485.8C
Melting pt:200C
Solubility:Water: 10 mg/mL (43.81 mM); DMSO: 45 mg/mL (197.18 mM)
Appearance:White Powder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

Regerences

1. Shaker S, et al. Leuk Res, 2003, 27(5), 437-444.

    Please let us know if you have published research using #S1508 so that we can cite your reference.
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