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HDAC4(Phospho-Ser632) Antibody

11192
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  Catalog No. Package Size Price
11192-1 50ul $189.00
11192-2 100ul $279.00

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Description
  • Product Name HDAC4(Phospho-Ser632) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of HDAC4 only when phosphorylated at serine 632.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of serine 632 (A-Q-S(p)-S-P) derived from Human HDAC4.
  • Target Name HDAC4
  • Modification Phospho
  • Alternative Names HD4
  • Accession No. Swiss-Prot: P56524
    NCBI Protein: NP_006028.2
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 140kd
Western blotting: 1:500~1:1000
 

Images
  • HDAC4(Phospho-Ser632) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from 293 cells untreated(lane 1) or treated with EGF(lane 2) using HDAC4(Phospho-Ser632) Antibody #11192.

Background

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912.
Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840.
 

  • S Lim, M Luo, M Koh et al,Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin ?-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone., Molecular and Cellular Biology, 27(11):4105-4120 (2007),
    PMID: 17371839
  • Please let us know if you have published research using #11192 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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