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PKR(Phospho-Thr446) Antibody

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  Catalog No. Package Size Price
11280-1 50ul $189.00
11280-2 100ul $279.00

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  • Product Name PKR(Phospho-Thr446) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous level of PKR only when phosphorylated at threonine 446.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of threonine 446 (K-R-T(p)-R-S) derived from Human PKR.
  • Target Name PKR
  • Modification Phospho
  • Alternative Names ADRB2; E2AK2; EIF2AK2; EIF2aK; PRKR
  • Accession No. Swiss-Prot: P19525
    NCBI Protein: NP_001129123.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 68kd
Western blotting: 1:500~1:1000

  • PKR(Phospho-Thr446) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from K562 cells using PKR(Phospho-Thr446) Antibody #11280(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).


Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

Abujiang Pataer, et,al. (2002) Cancer Res; 62: 2239.
K. D. Ryman, et,al. (2005) J. Virol; 79: 1487 - 1499.
Susana Guerra, et,al. (2006) J. Biol. Chem; 281: 18734 - 18745.

  • Suzette Laing, Guohui Wang, Tamara Briazova et al,Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues., Amerian Journal of Physiol Cell Physiol, 299(4):C736-749. doi:10.1152/ajpcell.00529.2009 (2010),
    PMID: 20554909
  • Please let us know if you have published research using #11280 so that we can cite your reference.
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    • NCNegative Control
      Species Reactivity:
    • HuHuman
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