-
Published Papers
Cat.No.
Product Name
Reference
11002
GSK3β (Phospho-Ser9) Antibody
Cong REN, Jia-Mou LI, Xin LIN (2010) LIPUS Enhance Elongation of Neurites in Rat Cortical Neurons through Inhibition of GSK-3β. Biomedical and Environmental Sciences, Volume 23, Issue 3, Pages 244-249
11002
GSK3β (Phospho-Ser9) Antibody
Yingjuan Yang, Jinzeng Yang, Rongxin Liu, Huixia Li and Xiao Luo, et al.Accumulation of β-catenin by lithium chloride in porcine myoblast cultures accelerates cell differentiation.Molecular Biology Reports, 2011, Volume 38, Number 3, Pages 2043-2049
11002
GSK3b(Phospho-Ser9) Antibody
Estefanía de Munck, Emma Mu˜noz-Sáez, Bego˜na G. Miguel, M. Teresa Solas,et al (2013) B-N-methylamino-l-alanine causes neurological andpathological phenotypes mimicking Amyotrophic LateralSclerosis (ALS): The first step towards an experimentalmodel for sporadic ALS. environmental toxicology and pharmacology 36:243–255
11002
GSK3b(Phospho-Ser9) Antibody
Yu-fei Pan, Li-wei Dong, Min Wang, Guang-zhen Yang, et al. (2013) Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation. Eur. J. Immunol. 43: 1598–1607
11002
GSK3b(Phospho-Ser9) Antibody
Lei Hana, Yang Yanga, Xiao Yuea, Kai Huanga, et al. (2010) Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. BRAIN RESEARCH 1366:9–17
11002
GSK3b(Phospho-Ser9) Antibody
Wen-Fei Tan, Xue-Zhao Cao, Jun-KeWang, Huang-Wei Lv, et al. (2010) Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and Experimental Pharmacology and Physiology. 37:1010–1015
11002
GSK3b(Phospho-Ser9) Antibody
Jiamou Li, Hua Zhang, Cong Ren. (2012) Effect of Low-Intensity Pulsed Ultrasound on Nerve Repair. Tissue Regeneration - From Basic Biology to Clinical Application, Prof. ISBN: 978-953-51-0387-5,
11005
PDK1 (Phospho-Ser241) Antibody
Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press,
11005
PDK1(Phospho-Ser241) Antibody
Dan Liu, Yi Huang, Bojiang Chen, Jing Zeng, et al. (2011) Activation of Mammalian Target of Rapamycin Pathway Confers Adverse Outcome in Nonsmall Cell Lung Carcinoma. DOI: 10.1002/cncr.25959
11006
Raf1(Phospho-Ser259) Antibody
Zhi-Xin Qiu, Lei Wang,Juan Han, Dan Liu, et al.(2012) Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer. Cancer Sci. vol. 103 no. 10 pp. 1774–1779
11007
GSK3α (Phospho-Ser21) Antibody
Dan Liu, Yi Huang, Jing Zeng, Bojiang Chen and Na Huang, et al.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Journal of Cancer Research and Clinical Oncology, 2011, Volume 137, Number 11, Pages 1629-164
11011
NFκB-p65 (Phospho-Ser276) Antibody
Anneleen Spooren, Krzysztof Kolmus, Linda Vermeulen,et al.(2010) Hunting for Serine 276-phosphorylated p65. Journal of Biomedicine and Biotechnology, 2010, Article ID 275892, 9 doi:10.1155/2010/275892
11011
NFκB-p65(Phospho-Ser276) Antibody
Xiaoping Cai, Saul Benedict Freedman, Paul Kenneth Witting.(2013) Serum amyloid A stimulates cultured endothelial cells to migrate and proliferate: inhibition by the multi-kinase inhibitor BIBF1120. doi: 10.1111/1440-1681.12148
11014
NFκB-p65 (Phospho-Ser536) Antibody
Jitakshi De, Robert E. Brown (2010)Tissue-microarray based immunohistochemical analysis of survival pathways in nodular sclerosing classical Hodgkin lymphoma as compared with Non-Hodgkin’s lymphoma. Int J Clin Exp Med,3(1):55-68
11015
NFκB-p100(Phospho-Ser866) Antibody
Chen Shen & Xin-liang Zhao &Weina Ju &Xiao-bing Zou & Li-rong Huo & Wu Yan & Jun-hua Zou &Guo-di Yan & Edmund C. Jenkins &W. Ted Brown &Nanbert Zhong,A Proteomic Investigation of B Lymphocytes in an Autistic Family: A Pilot Study of Exposure to Natural Rubber Latex (NRL) May Lead to Autism,J Mol Neurosci (2011) 43:443–452
11021
c-Jun(Phospho-Thr91) Antibody
Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D. Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215
11024
c-Jun (Phospho-Thr239) Antibody
Soichiro Yamamura, Kazumori Kawakami, Hiroshi Hirata,et al(2010) Oncogenic Functions of Secreted Frizzled-Related Protein 2 in Human Renal Cancer. Molecular Cancer Therapeurics
11025
c-Jun (Phospho-Ser243) Antibody
Soichiro Yamamura, Kazumori Kawakami, Hiroshi Hirata,et al(2010) Oncogenic Functions of Secreted Frizzled-Related Protein 2 in Human Renal Cancer. Molecular Cancer Therapeurics
11026
JunB(Phospho-Ser79) Antibody
Raffi Vartanian1, Janine Masri, Jheralyn Martin, Cheri Cloninger, et al. (2010) AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation. American Association for Cancer Research. DOI: 10.1158/1541-7786
11027
JunB(Phospho-Ser259) Antibody
Raffi Vartanian1, Janine Masri, Jheralyn Martin, Cheri Cloninger, et al. (2010) AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation. American Association for Cancer Research. DOI: 10.1158/1541-7786
11039
MEF2A (Phospho-Thr312) Antibody
K Satoh, J Ohnishi, A Sato, et al. (2007) Nemo-Like Kinase-Myocyte Enhancer Factor 2A Signaling Regulates Anterior Formation in Xenopus Development.Molecular and Cellular Biology, 27(21):7623-30.
11044
STAT1 (Phospho-Tyr701) Antibody
Jelke J. Fros, Wen Jun Liu, Natalie A. Prow, et al (2010)Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling. Journal of Virology, 84(20)10877-10887
11044
STAT1 (Phospho-Tyr701) Antibody
Hirokazu Hara, Yoko Nakamura, Masayuki Ninomiya, et al(2011) Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. ‘hidabeni’ and their synthetic derivatives on LPS-induced NO production in microglia. Bioorganic & Medicinal Chemistry, Volume 19, Issue 18, Pages 5559-5568
11044
STAT1(Phospho-Tyr701) Antibody
C.-C.E. Lan, C.-S. Wu, S.-M. Huang, H.-Y. Kuo, et al.(2012) High-glucose environment reduces human b-defensin-2 expression in human keratinocytes: implications for poor diabetic wound healing. British Association of Dermatologists. 166, pp1221–1229
11044
STAT1(Phospho-Tyr701) Antibody
Hsin-Chien Chen,1,2 Hsin-I Ma,1,3 Huey-Kang Sytwu,1,4 Hsing-Won Wang, Chia-Chi V. Chen,5 Shu-Chen Liu,2 Chi-Huang Chen,6 Hang-Kang Chen, and Chih-Hung Wang, Neural Stem Cells Secrete Factors That Promote Auditory Cell Proliferation Via a Leukemia Inhibitory Factor Signaling Pathway,Journal of Neuroscience Research 88:3308–3318 (2010)
11045
STAT3 (Phospho-Tyr705) Antibody
Yuan Guogang,Lu Qian ,Ming Shi (2008) HER2-dependent MMP-7 expression is mediated by activated STAT3.Cellular Signalling, 20:1284–1291
11045
STAT3 (Phospho-Tyr705) Antibody
H Yamaguchi, J Zhu, T Yu, et al. (2006) Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation.Toxicology, 226:131-142.
11045
STAT3 (Phospho-Tyr705) Antibody
Yamaguchi, J Zhu, T Yu, et al. (2007) Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.
11045
STAT3 (Phospho-Tyr705) Antibody
Li-Nan Ren , Qing-Fang Li , Feng-Jun Xiao, et al (2009)Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein.Biochemical and Biophysical Research Communications 386:35–39
11045
STAT3 (Phospho-Tyr705) Antibody
Jian-Guo Zhang, Jing Zhao, and Yan Xin, et al (2010) Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions. World J Gastroenterol. 16(5): 571–577.
11045
STAT3 (Phospho-Tyr705) Antibody
Takuya Takeichi, Kazumitsu Sugiura, Yoshinao Muro, et al (2010)Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that Seen in the Psoriatic Condition. Journal of Investigative Dermatology 130, 2760-2767
11045
STAT3 (Phospho-Tyr705) Antibody
Emilio García-Prieto, Adrián González-López,, Sandra Cabrera, et al (2010)Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10. PloS one, 5(10): e13242.
11045
STAT3(Phospho-Tyr705) Antibody
Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16
11045
STAT3(Phospho-Tyr705) Antibody
Feng-Ze Wanga,b, Peng-Jiaoc, Na-Na Yangc, Chuang-Yuana, Ya-Li Zhaoa, Qiang-Qiang Liua, Hong-Rong Fei d, Ji-Guo Zhang, PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells, Toxicology Letters 220 (2013) 150– 156
11046
STAT3 (Phospho-Ser727) Antibody
H Yamaguchi, J Zhu, T Yu, et al. (2006) Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation.Toxicology, 226:131-142.
11046
STAT3 (Phospho-Ser727) Antibody
Yamaguchi, J Zhu, T Yu, et al. (2007) Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.
11046
STAT3 (Phospho-Ser727) Antibody
Jian-Guo Zhang, Jing Zhao, and Yan Xin, et al (2010) Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions. World J Gastroenterol. 16(5): 571–577.
11046
STAT3(Phospho-Ser727) Antibody
ANIRBAN MAJUMDER, SASWATI BANERJEE, JOSHUA A. HARRILL, DAVID W. MACHACEK,et al (2012) Neurotrophic Effects of Leukemia Inhibitory Factor on Neural Cells Derived from Human Embryonic Stem Cells. STEM CELLS. 30:2387–2399
11046
STAT3(Phospho-Ser727) Antibody
Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, et al. (2011) Canonical Notch Pathway Protects Hepatocytes from Ischemia/Reperfusion Injury in Mice by Repressing Reactive Oxygen Species Production Through JAK2/STAT3 Signaling. HEPATOLOGY, Vol. 54, No. 3, 979-988
11046
STAT3(Phospho-Ser727) Antibody
Feng-Ze Wanga,b, Peng-Jiaoc, Na-Na Yangc, Chuang-Yuana, Ya-Li Zhaoa, Qiang-Qiang Liua, Hong-Rong Fei d, Ji-Guo Zhang, PF-04691502 triggers cell cycle arrest, apoptosis and inhibits the angiogenesis in hepatocellular carcinoma cells, Toxicology Letters 220 (2013) 150– 156
11048
STAT5a(Phospho-Tyr694) Antibody
Drechsler J, Gro¨ tzinger J, Hermanns HM (2012) Characterization of the Rat Oncostatin M Receptor Complex Which Resembles the Human, but Differs from the Murine Cytokine Receptor. PLoS ONE 7(8): e43155. doi:10.1371/journal.pone.0043155
11052
anti-phospho CREB antibody
Tomasz Boczek, Anna Kozaczuk, Bozena Ferenc, Michalina Kosiorek and Slawomir Pikula, et al.Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin.Molecular and Cellular Biochemistry, 12 September 2011
11054
Akt (Phospho-Ser473) Antibody
Zhi Wang, Guotong Xu, Yalan Wu, et al. (2007) Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells.Medical and Biological Engineering and Computing, 47:41–48
11054
Akt (Phospho-Ser473) Antibody
Seyoon Kim, Yong Zu Lee, Yu Sam Kim,et al (2008)A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. Proteomics, 8 (15), 3082 - 3093
11054
Akt (Phospho-Ser473) Antibody
Young Yil Bahk, Ick-Hyun Cho, Tong Soo Kim. (2008)A Cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts,.Biochemical and Biophysical Research Communications, 377:1199–1204.
11054
Akt (Phospho-Ser473) Antibody
Hui Zhou, Jing Zhao, Xujia Zhang. (2009) Inhibition of uncoupling protein 2 by genipin reduces insulin-stimulated glucose uptake in 3T3-L1 adipocytesArchives of Biochemistry and Biophysics, 486:88–93
11054
Akt (Phospho-Ser473) Antibody
Jing Zhang, Osamu Yamada, Yoshihisa Matsushita, ect.(2009)Transactivation of human osteopontin promoter by human T-cell leukemia virus type 1-encoded Tax protein Leukemia Research in press.
11054
Akt (Phospho-Ser473) Antibody
Li-Nan Ren , Qing-Fang Li , Feng-Jun Xiao, et al (2009)Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein.Biochemical and Biophysical Research Communications 386 (2009) 35–39
11054
Akt(Phospho-Ser473) Antibody
Ning LI, Geng-tao LIU. (2010) The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta Pharmacologica Sinica. 31: 265–272
11054
Akt (Phospho-Ser473) Antibody
Sheng-Li Lin , Li-Ying Yan , Xin-Tian Zhang ,et al.(2010)ER-a36, a Variant of ER-a, Promotes Tamoxifen Agonist Action in Endometrial Cancer Cells via the MAPK/ERK and PI3K/Akt Pathways. PLoS ONE 5(2): e9013. doi:10.1371/journal.pone.0009013
11054
Akt (Phospho-Ser473) Antibody
Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press
11054
Akt(Phospho-Ser473) Antibody
Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, et al. (2011) Canonical Notch Pathway Protects Hepatocytes from Ischemia/Reperfusion Injury in Mice by Repressing Reactive Oxygen Species Production Through JAK2/STAT3 Signaling. HEPATOLOGY, Vol. 54, No. 3, 979-988
11054
Akt(Phospho-Ser473) Antibody
Hu Ma, Quan Yao, An-Mei Zhang, Sheng Lin, Xin-Xin Wang, Lei Wu, Jian-Guo Sun,and Zheng-Tang Chen(2011)The Effects of Artesunate on the Expression of EGFR and ABCG2 in A549 Human Lung Cancer Cells and a Xenograft Model. Molecules 2011, 16, 10556-10569; doi:10.3390/molecules161210556
11054
Akt(Phospho-Ser473) Antibody
Marc Vendrell, Anabel Molero, Sergio Gonzalez, Kamil Perez-Capote, et al. (2011) Biotin Ergopeptide Probes for Dopamine Receptors. J. Med. Chem. 54, 1080–1090
11054
Akt (Phospho-Ser473) Antibody
Yingjia Guo, Tong Yang, Jun Lu, et al (2011) Rb1 postconditioning attenuates liver warm ischemia–reperfusion injury through ROS-NO-HIF pathway. Life Sciences, Volume 88, Issues 13-14, Pages 598-605
11054
Akt(Phospho-Ser473) Antibody
Lucía Callén, Estefanía Moreno, Pedro Barroso-Chinea, David Moreno-Delgado, Antoni Cortés,et al (2012) Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 25, pp. 20851–20865,
11054
Akt(Phospho-Ser473) Antibody
Fang Wang a,b,1, Ting Li a,1, Bin Zhang c,1, Hong Li a, Qiong Wua, Li Yang b,⇑, Yongzhan Nie a, Kaichun Wua, Yongquan Shi a,⇑, Daiming Fan,Biochemical and Biophysical Research Communications, Biochemical and Biophysical Research Communications 434 (2013) 688–694
11054
anti-phospho-STAT3
Heng-Fei Luan1*, Zhi-Bin Zhao1*, Qi-Hong Zhao2, Pin Zhu1, Ming-Yu Xiu1 and Yong Ji, Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway
11054
Akt(Phospho-Ser473) Antibody
Hongxia Zhanga,1, Junjie Houb,1, Ruina Cuia, Xuejiang Guoc, Zhimin Shia, Fuquan Yangb, Jiayin Daia, Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters 218 (2013) 61– 69
11054
Akt(Phospho-Ser473) Antibody
Jia J, Xu X, Liu F, Guo X, Zhang M, et al. (2013) Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening. PLoS ONE 8(4): e59315. doi:10.1371/journal.pone.0059315
11054
Akt(Phospho-Ser473) Antibody
Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16
11054
Akt(Phospho-Ser473) Antibody
Peter Schubert, Danielle Coupland, Brankica Culibrk, Raymond P. Goodrich, et al. (2013) Riboflavin and ultraviolet light treatment of platelets triggers p38MAPK signaling: inhibition significantly improves in vitro platelet quality after pathogen reduction treatment. TRANSFUSION. Volume **, ** **
11054
Akt(Phospho-Ser473) Antibody
Yunye Ning, Haidong Huang, Yuchao Dong, Qinying Sun,ett al. (2013) 5-Aza-20-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching. Arch Toxicol 87:871–881
11054
Akt(Phospho-Ser473) Antibody
Shen J, et al., The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy, Biomaterials (2013) Volume 35, Issue 1, January 2014, Pages 316–326
11055
Akt (Phospho-Thr308) Antibody
Alexandra V. Andreeva, Jingyan Han, Mikhail A. Kutuzov ,et al.(2010)Journal of cellular Physiology, 223(1) 1, 94 - 102 T-cadherin modulates endothelial barrier function.
11055
Akt (Phospho-Thr308) Antibody
Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press
11055
Akt(Phospho-Thr308) Antibody
Yingjia Guo, Tong Yang, Jun Lu, Shengfu Li, et al. (2011) Rb1 postconditioning attenuates liver warm ischemia–reperfusion injury through ROS-NO-HIF pathway. Life Sciences. 88:598–605
11055
Akt(Phospho-Thr308) Antibody
Yunye Ning, Haidong Huang, Yuchao Dong, Qinying Sun,ett al. (2013) 5-Aza-20-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching. Arch Toxicol 87:871–881
11055
Akt(Phospho-Thr308) Antibody
Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83
11055
Akt(Phospho-Thr308) Antibody
Hongxia Zhanga,1, Junjie Houb,1, Ruina Cuia, Xuejiang Guoc, Zhimin Shia, Fuquan Yangb, Jiayin Daia, Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters 218 (2013) 61– 69
11057
p95/NBS1 (Phospho-Ser343) Antibody
F Carrillo, SA Schneider, AMR Taylor, et al (2009) Prominent Oromandibular Dystonia and Pharyngeal Telangiectasia in Atypical Ataxia Telangiectasia. Cerebellum, 8:22–27
11057
p95/NBS1(Phospho-Ser343) Antibody
Rachid Drissi, Jing Wu, Yafang Hu, Carol Bockhold, and Jeffrey S. Dome(2011)Cancer Prevention Research, 4(12) December 2011
11059
FAK (Phospho-Tyr861) Antibody
Liang Wu , Lei Zhu , Wei-Hao Shi , et al. (2008) Zoledronate inhibits the proliferation,adhesion and migration of vascular smooth muscle cells.European Journal of Pharmacology, 602, 124–131
11059
FAK (Phospho-Tyr861) Antibody
Baiyang Sheng, Bo Song, Zhenhuan Zheng, (2009) Abnormal cleavage of APP impairs its functions in cell adhesion and migration.Neuroscience Letters, 450, 327–33
11059
FAK (Phospho-Tyr861) Antibody
Z Zheng, Y Wei, et al.( 2008) Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration.Journal of Biomaterials Applications,24:209-229
11059
FAK(Phospho-Tyr861) Antibody
Masahiko Kanehira, Toshiaki Kikuchi, Shinya Ohkouchi, Taizou Shibahara, et al. (2012) Targeting Lysophosphatidic Acid Signaling Retards Culture-Associated Senescence of Human Marrow Stromal Cells.PLoS ONE 7(2): e32185. doi:10.1371/journal.pone.0032185
11062
PTEN(Phospho-Ser370) Antibody
Zhi Li & Gong Xiang Liu & Yu Lan Liu & Xi Chen & Xiao Li Huang & Hua Tian Gan, Effect of adenovirus-mediated PTEN gene on ulcerative colitis-associated colorectal cancer, Int J Colorectal Dis (2013) 28:1107–1115
11063
Ezrin (Phospho-Tyr353) Antibody
Yazhou Cui, Tianliang Li, Denglu Zhang,et al.(2010)Expression of Ezrin and Phosphorylated Ezrin (pEzrin) in Pancreatic Ductal Adenocarcinoma. Cancer Investigation 28(3) 242-247
11063
Ezrin(Phospho-Tyr353) Antibody
Yasunori Oda MD, Shinichi Aishima PhD, Katsuya Morimatsu PhD,Akifumi Hayashi PhD, et al.(2012) Differential ezrin and phosphorylated ezrin expression profiles between pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and invasive ductal carcinoma of the pancreas. Human Pathology 44:1487–1498
11066
p-Bcl-xl (Ser62)
Dan Liu, Yi Huang, Jing Zeng, Bojiang Chen and Na Huang, et al.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Journal of Cancer Research and Clinical Oncology, 2011, Volume 137, Number 11, Pages 1629-164
11068
BAD (Phospho-Ser136) Antibody
N Matsuda, Y Takano, S Kageyama, et al.(2007) Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock.Cardiovascular Research,76:132-140.
11068
BAD (Phospho-Ser136) Antibody
S. Otsuki, K. Sugiyama, O. Amano, T. Yasui, H. Sakagami (2011) Negative regulation of NaF-induced apoptosis by Bad–CAII complex. Toxicology, Volume 287, Issues 1-3,Pages 131-136
11073
Estrogen Receptor-α (Phospho-Ser167) Antibody
Kazuyoshi Motomura, Makoto Ishitobi, Yoshifumi Komoike, et al (2010) Expression of Estrogen Receptor Beta and Phosphorylation of Estrogen Receptor Alpha Serine 167 Correlate with Progression-Free Survival in Patients with Metastatic Breast Cancer Treated with Aromatase Inhibitors. Oncology,79,1-2
11075
HER2(Phospho-Tyr877) Antibody
M.Alicia Corte´s1, Ariel E.Cariaga-Martinez1,Marı´a V.T.Lobo2,3, Rosa M.Martı´n Orozco1, Omar Motin˜o1,F.Javier Rodrı´guez-Ubreva1,4, Javier Angulo5,Pilar Lo´pez-Ruiz1 and Begon˜a Cola´s1,EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway,Carcinogenesis vol.33 no.6 pp.1169–1177, 2012
11079
HER2 (Phospho-Tyr1248) Antibody
Yuan Guogang,Lu Qian ,Ming Shi (2008)HER2-dependent MMP-7 expression is mediated by activated STAT3Cellular Signalling, 20:1284–1291
11088
anti-phospho-IGF-1R (1165/1166)
Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press,
11090
Caveolin-1 (Phospho-Tyr14) Antibody
André Bento-Abreu, Ana Velasco, Erica Polo-Hernández,et al(2009)Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid. Journal of Neurochemistry,111 (1), Pages 49 - 60
11092
p53(Phospho-Ser6) Antibody
Yan-Qing Guan a,1, Zhibin Li a,1, Aini Yang a, Zheng Huang a, Zhe Zheng a, Lin Zhang a, Ling Li a, Jun-Ming Liu, Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-a plus IFN-g on polystyrene and the role of p53 activation, Contents lists available at SciVerse ScienceDirect
11098
p53(Phospho-Ser37) Antibody
Yan-Qing Guan a,1, Zhibin Li a,1, Aini Yang a, Zheng Huang a, Zhe Zheng a, Lin Zhang a, Ling Li a, Jun-Ming Liu, Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-a plus IFN-g on polystyrene and the role of p53 activation, Contents lists available at SciVerse ScienceDirect
11100
p53(Phospho-Ser315) Antibody
Yan-Qing Guan a,1, Zhibin Li a,1, Aini Yang a, Zheng Huang a, Zhe Zheng a, Lin Zhang a, Ling Li a, Jun-Ming Liu, Cell cycle arrest and apoptosis of OVCAR-3 and MCF-7 cells induced by co-immobilized TNF-a plus IFN-g on polystyrene and the role of p53 activation, Contents lists available at SciVerse ScienceDirect
11102
Tau(Phospho-Ser396) Antibody
Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, et al. (2012) Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 14, pp. 11174–11182
11102
Tau(Phospho-Ser396) Antibody
Li-Ming Chen, Yan-Si Xiong, Fan-Li Kong, Min Qu, et al. (2012) Neurolobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. JOURNAL OF NEUROCHEMISTRY. 120:157–164
11102
Tau(Phospho-Ser396) Antibody
Wen-Fei Tan, Xue-Zhao Cao, Jun-KeWang, Huang-Wei Lv, et al. (2010) Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and Experimental Pharmacology and Physiology. 37:1010–1015
11103
PLCγ1 (Phospho-Tyr783) Antibody
Cheng-Ying Hsieh, Chien-Liang Liu, Ming-Jen Hsu, Thanasekaran Jayakumar, et al. (2010) Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation. Free Radical Biology & Medicine. 49:881–893
11103
PLCgamma1(Phospho-Tyr783) Antibody
Yu-fei Pan, Li-wei Dong, Min Wang, Guang-zhen Yang, et al. (2013) Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation. Eur. J. Immunol. 43: 1598–1607
11106
Tau(Phospho-Ser235) Antibody
Johanne Bertrand, Patrick Senechal, Mathieu Zummo-Soucy, Vanessa Plouffe, et al. (2010) The formation of tau pathological pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in prinmary hippocampal neurons over-expressing human tau. JOURNAL OF NEUROCHEMISTRY. 114:1353–1367
11107
Tau(Phospho-Thr181) Antibody
Lara Ordóñez-Gutiérrez, Juan María Torres, Rosalina Gavín, Marta Antón, et al. (2013) Cellular prion protein modulates b-amyloid deposition in aged APP/PS1 transgenic mice. Neurobiology of Aging. xxx:1-12
11108
Tau(Phospho-Thr205) Antibody
Tan Wenfei, Cao Xuezhao,Wang Junke,et al. (2010)Tau hyperphosphorylation is associated with memory impairment after exposure to 1.5% isoflurane without temperature maintenance in rats.European Journal of Anaesthesiology, doi: 10.1097/EJA.0b013e32833a6561
11108
Tau(Phospho-Thr205) Antibody
Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, et al. (2012) Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 14, pp. 11174–11182
11108
Tau(Phospho-Thr205) Antibody
Li-Ming Chen, Yan-Si Xiong, Fan-Li Kong, Min Qu, et al. (2012) Neurolobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. JOURNAL OF NEUROCHEMISTRY. 120:157–164
11108
Tau(Phospho-Thr205) Antibody
Wen-Fei Tan, Xue-Zhao Cao, Jun-KeWang, Huang-Wei Lv, et al. (2010) Protective effects of lithium treatment for spatial memory deficits induced
by tau hyperphosphorylation in splenectomized rats. Clinical and Experimental Pharmacology and Physiology. 37:1010–101511110
Tau(Phospho-Thr231) Antibody
Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, et al. (2012) Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 14, pp. 11174–11182
11110
Tau(Phospho-Thr231) Antibody
Li-Ming Chen, Yan-Si Xiong, Fan-Li Kong, Min Qu, et al. (2012) Neurolobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. JOURNAL OF NEUROCHEMISTRY. 120:157–164
11111
Tau(Phospho-Ser262)Antibody
J. Bertrand, V. Plouffe, P. Sénéchal, N. Leclerc, et al(2010) The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience, Volume 168, Issue 2, Pages 323-334
11111
Tau(Phospho-Ser262) Antibody
Vanessa Plouffe. (2011) The secretion of the Tau protein: a new mechanism propagation of the pathology of Tau in the disease Alzheimer. University of Montreal Faculty of Graduate and Postdoctoral Studies.
11112
Tau(Phospho-Ser404) Antibody
Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, et al. (2012) Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A). THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 14, pp. 11174–11182
11112
Tau(Phospho-Ser404) Antibody
Li-Ming Chen, Yan-Si Xiong, Fan-Li Kong, Min Qu, et al. (2012) Neurolobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. JOURNAL OF NEUROCHEMISTRY. 120:157–164
11115
FKHR (Phospho-Ser256) Antibody
Zhan Lixuan ,Tao Wang,Wen Li ,et al.(2010)Journal of Neurochemistry doi: 10.1111/j.1471-4159.2010.06816.xActivation of AKT/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hipoxic pre-conditioning in adult rats.
11115
FKHR(Phospho-Ser256) Antibody
Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16
11122
ATM (Phospho-Ser1981) Antibody
Bin Kang ,Ruifang Guo,Xiao-hui Tian , et al.(2008) Expression status of ataxia telangiectasia mutated gene coorelated with Prognosis in advanced gastric cancer.Mutation Research, 638: 17-25
11122
ATM (Phospho-Ser1981) Antibody
J Leemput, C Masson, K Bigot . ATM localization and gene expression in the adult mouse eye.Molecular Vision 15: 393–416
11122
ATM(Phospho-Ser1981) Antibody
Dashayini Mahalingam, Ling L. Tay, Wei H. Tan, Juin H. Chai, et al. (2011) Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts. FEBS Journal 278:3724–3738
11122
ATM(Phospho-Ser1981) Antibody
Hiroaki Inaba, Masae Kuboniwa, Hideyuki Sugita, Richard J. Lamont and Atsuo Amano, Identification of Signaling Pathways Mediating Cell Cycle Arrest and Apoptosis Induced by Porphyromonas gingivalis in Human Trophoblasts, Infect. Immun. 2012, 80(8):2847. DOI: 10.1128/IAI.00258-12.
11123
FAK (Phospho-Tyr925) Antibody
Z Zheng, Y Wei, et al.( 2008)Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration. Journal of Biomaterials Applications,24:209-229
11126
LIMK1 (Phospho-Thr508) Antibody
Li, X., Ke, Q., Li, Y., Liu, F., Zhu, G., & Li, F., et al. (2008) DGCR6L, A Novel PAK4 Interaction Protein, Regulates PAK4-mediated migration of Human Gastric Cancer Cell via LIMK1.International Journal of Biochemistry and Cell Biology, 42: 70–79
11130
Rb (Phospho-Ser795) Antibody
Fang Sun , Hanjiang Fu , Qin Liu, et al. (2008)Downregulation of CCND1 and CDK6 by miR-34a induces cell cyclearrest. FEBS Letters, 582:1564–1568.
11130
Rb(Phospho-Ser795) Antibody
Heidi Braumuller, ThomasWieder, Ellen Brenner, Sonja Aßmann, et al. (2013) T-helper-1-cell cytokines drive cancer into senescence. NATURE.494:361-366
11131
Rb (Phospho-Ser807) Antibody
Qin Liu, Hanjiang Fu, Fang Sun, et al. (2008) miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res., 36: 5391-5404.
11132
Rb(Phospho-Ser780)Antibody
Xueting Cai, Tingmei Ye, Chao Liu, et al (2011) Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicology in Vitro, Volume 25, Issue 7, Pages 1385-1391
11137
AFX (Phospho-Ser197) Antibody
Zhan Lixuan ,Tao Wang,Wen Li ,et al.(2010)Journal of Neurochemistry doi: 10.1111/j.1471-4159.2010.06816.xActivation of AKT/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hipoxic pre-conditioning in adult rats.
11138
cdc25A(Phospho-Ser76) Antibody
Shunfu Piao,1 Su-Jin Lee,2 Yongbin Xu,1 Jungsug Gwak,3 Sangtaek Oh,3 Bum-Joon Park2,* and Nam-Chul Ha, CK1ε targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation, Cell Cycle 10:3, 531-537; February 1, 2011
11139
cofilin(Phospho-Ser3) Antibody
Lijun Zhang, Jun Luo, Ping Wan, Jing Wu, et al. (2011) Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. Development. 138:455-464
11139
cofilin(Phospho-Ser3) Antibody
Guillaume Huet1, Eeva Kaisa Rajakyla, Tiina Viita1, Kari-Pekka Skarp, et al. (2012) Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool. Journal of Cell Science. 126:497–507
11139
cofilin(Phospho-Ser3) Antibody
Hui Guo, Yi Lv, Tao Tian, Ting Hua Hu, et al. (2011) Downregulation of p57 accelerates the growth and invasion of hepatocellular carcinoma. Carcinogenesis vol.32 no.12 pp.1897–1904
11142
Vav (Phospho-Tyr174) Antibody
Yuichi Sekine,Osamu Ikeda, Satoshi Tsuji, et al (2009) Signal-Transducing Adaptor Protein-2 Regulates Stromal Cell-Derived Factor-1 -Induced Chemotaxis in T Cells. The Journal of Immunology, 183:7966 -7974
11144
Lck(Phospho-Tyr394) Antibody
C. Annette Hollmanna, Alexandar Tzankovb, Verónica L. Martínez-Marignaca, Kristi Bakerc, Czeslawa Grygorczykf, Ryszard Grygorczykf, William Foulkesa,d, Jay Nadeaue, Stephan Dirnhoferb, Raquel Aloyza, Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell lymphoma ,Leukemia Research 34 (2010) 585–593
11149
phosphorylated (p-)JAK1 (Tyr1022)
Dan Liu, Yi Huang, Jing Zeng, Bojiang Chen and Na Huang, et al.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Journal of Cancer Research and Clinical Oncology, 2011, Volume 137, Number 11, Pages 1629-164
11149
JAK1(Phospho-Tyr1022) Antibody
YOUNG CHA, BO-HYUN MOON, MI-OK LEE, HEE-JIN AHN, et al. (2010) Zap70 Functions to Maintain Stemness of Mouse Embryonic Stem Cells by Negatively Regulating Jak1/Stat3/c-Myc Signaling. STEM CELLS. 28:1476–1486
11152
IκBα (phospho-Ser32/Ser36)
Zhenghua Ren, Jianhua Cui, Zeren Huo, Jinru Xue,et al.(2012) Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination. International Immunopharmacology.14:698-703
11153
Src (Phospho-Tyr529) Antibody
Yanhua Zheng, Yan Xia, Xiang Gao, Zhimin Lu, et al. (2009) FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST.Molecular Cell,35:11–25
11153
Src(Phospho-Tyr529) Antibody
Dr. Marcia Liz.(2010-2011) Glycogen Synthase Kinase 3β modulation in axonal regeneration. Autonomous Section of Health Sciences.
11157
FKHRL1(Phospho-Ser253)Antibody
Zhan Lixuan ,Tao Wang,Wen Li ,et al.(2010)Journal of Neurochemistry doi: 10.1111/j.1471-4159.2010.06816.xActivation of AKT/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hipoxic pre-conditioning in adult rats.
11161
MEK1 (Phospho-Ser221) Antibody
Akira Ikari , Kosuke Atomi , Keishi Kinjo ,et al.(2010)Magnesium deprivation inhibits a MEK–ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. Life Sciences 86: 766–773
11163
STAT1(Phospho-Ser727) Antibody
C.-C.E. Lan, C.-S. Wu, S.-M. Huang, H.-Y. Kuo, et al.(2012) High-glucose environment reduces human b-defensin-2 expression in human keratinocytes: implications for poor diabetic wound healing. British Association of Dermatologists. 166, pp1221–1229
11164
HSP27(Phospho-Ser15) Antibody
Ah-Mee Park a, MasatoshiKudo b, SatoruHagiwara b, MasakiTabuchi c, TomohiroWatanabe d,Hiroshi Munakata a, ToshiharuSakurai b,n, p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression,Free RadicalBiologyandMedicine52(2012)2284–2291
11172
PKCβ(Phospho-Thr641) Antibody
Jack N. Losso, Robert E. Truax,,Gerald Richard, et al (2010) trans-Resveratrol Inhibits Hyperglycemia-Induced Inflammation and Connexin Downregulation in Retinal Pigment Epithelial Cells. Journal of Agricultural and Food Chemistry, 58 (14), 8246–8252
11177
SEK1/MKK4(Phospho-Ser80) Antibody
Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D.Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215
11178
ASK1 (Phospho-Ser83) Antibody
Min Yang, Mingcan Yu, Dongyin Guan,et al(2010) ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. Journal of Cellular Biochemistry,110(3), 581 - 588
11178
ASK1(Phospho-Ser83) Antibody
Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D. Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215
11179
ASK1 (Phospho-Ser966) Antibody
Min Yang, Mingcan Yu, Dongyin Guan,et al(2010) ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. Journal of Cellular Biochemistry,110(3), 581 - 588
11184
Histone H3.1(Phospho-Ser10) Antibody
Zenglin Liao†, Jiajia Dong†, Wei Wu, Ting Yang, Tao Wang, Lingli Guo, Lei Chen, Dan Xu and Fuqiang Wen, Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway, Liao et al. Respiratory Research 2012, 13:110
11184
Histone H3.1(Phospho-Ser10) Antibody
Lian-Qing Sun 1, Ying-Ying Chen 1, Xuan Wang, Xiao-Jin Li, Bing Xue, Ling Qu, Ting-Ting Zhang,Yi-Ming Mu, Ju-Ming Lu,The protective effect of Alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose, Biochemical Pharmacology 84 (2012) 961–973
11184
Histone H3.1(Phospho-Ser10) Antibody
Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
(2014), http://dx.doi.org/10.1016/j.molcel.2013.11.00111184
Histone H3.1(Phospho-Ser10) Antibody
Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.
11192
HDAC4 (Phospho-Ser632) Antibody
S Lim, M Luo, M Koh, et al. (2007) Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin ß-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone.Molecular and Cellular Biology, 27(11):4105-4120.
11193
HDAC5 (Phospho-Ser498) Antibody
J Bossuyt, K Helmstadter, X Wu, et al. (2008) Ca2+/Calmodulin-Dependent Protein Kinase II {delta} and Protein Kinase D Overexpression Reinforce. Circulation Research, 102(6):695-702.
11193
HDAC5 (Phospho-Ser498) Antibody
Pang J, Yan C, Natarajan K, et al. (2008) GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5):892-8.
11193
HDAC5 (Phospho-Ser498) Antibody
S Lim, M Luo, M Koh, et al. (2007) Distinct Mechanisms Involving Diverse Histone Deacetylases Repress Expression of the Two Gonadotropin ß-Subunit Genes in Immature Gonadotropes, and Their Actions Are Overcome by Gonadotropin-Releasing Hormone.Molecular and Cellular Biology, 27(11):4105-4120.
11193
HDAC5 (Phospho-Ser498) Antibody
Weiye Wang, Chang Hoon Ha, Bong Sook Jhun,et al(2010)Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Blood, 115( 14), 2971-2979.
11193
HDAC5 (Phospho-Ser498) Antibody
Sheng Xia,Xiaogang Li,Teri Johnson,et al (2010)Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.Development, 137, 1075-1084.
11201
Paxillin (Phospho-Tyr31) Antibody
Zhi Huang, Da-Peng Yan, Bao-Xue Ge,et al. (2008)JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin.Cellular Signalling ,20: 2002-2012
11202
Ezrin (Phospho-Thr567) Antibody
Yazhou Cui, Tianliang Li, Denglu Zhang,et al.(2010)Expression of Ezrin and Phosphorylated Ezrin (pEzrin) in Pancreatic Ductal Adenocarcinoma. Cancer Investigation 28(3) 242-247
11215
FAK (Phospho-Tyr397) Antibody
Z Zheng, Y Wei, et al.( 2008) Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration.Journal of Biomaterials Applications,24:209-229
11215
FAK(Phospho-Tyr397) Antibody
JUNSHAN RUAN1,3*, LEI ZHANG1*, LINGGENG YAN1, YUPING LIU1, ZHIQIANG YUE1, LI CHEN1,AI-YUN WANG1, WENXING CHEN1, SHIZHONG ZHENG1, SHAOMING WANG3 and YIN LU, Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells, MOLECULAR MEDICINE REPORTS 6: 232-238, 2012
11216
Pyk2(Phospho-Tyr402) Antibody
Mineko Tomomura, Hiroya Hasegawa, Naoto Suda, Hiroshi Sakagami, et al. (2012) Serum Calcium-decreasing Factor, Caldecrin, Inhibits Receptor Activator of NF- B Ligand (RANKL)-mediated Ca2 Signaling and Actin Ring Formation in Mature Osteoclasts via Suppression of Src Signaling Pathway. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 22, pp. 17963–17974
11219
β-Catenin (Phospho-Ser37) Antibody
Yuhua Li , Yinbo Niu , Huanjie Wu,et al.(2010) PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo. Cancer Science,100(12) 2451 - 2458
11220
EGFR(Phospho-Tyr1172) Antibody
Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.
11220
EGFR(Phospho-Tyr1172) Antibody
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.
11221
mTOR(Phospho-Ser2448) Antibody
Macias M, Blazejczyk M, Kazmierska P, Caban B, Skalecka A, et al. (2013) Spatiotemporal Characterization of mTOR Kinase Activity Following Kainic Acid Induced Status Epilepticus and Analysis of Rat Brain Response to Chronic Rapamycin Treatment. PLoS ONE 8(5): e64455. doi:10.1371/journal.pone.0064455
11221
mTOR(Phospho-Ser2448) Antibody
Yunye Ning, Haidong Huang, Yuchao Dong, Qinying Sun,ett al. (2013) 5-Aza-20-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching. Arch Toxicol 87:871–881
11223
4E-BP1 (Phospho-Thr45) Antibody
Jiumei Cao,Limin Gong, Dong-chuan Guo,et al.(2010)Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/– mice. Human Molecular Genetics, doi:10.1093/hmg/ddq066
11232
S6 Ribosomal Protein(Phospho-Ser235) Antibody
Zeynep Nesli ERDEM.(2011) FGFR4 mediated Growth and Survival signals in Colon Carcinoma cells.
11240
Phospho-c-Kit (Tyr721) antibody
Xiao-ning Gao, Ji Lin, Li Gao, et al (2011)MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia. Leukemia Research, Volume 35, Issue 9, September 2011, Pages 1226-1232
11244
CDC2(Phospho-Tyr15) Antibody
Qi Yao, Hui Li, Bing-Qian Liu, Xin-Yun Huang, et al. (2013) SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 31, pp. 27342–27349
11244
CDC2(Phospho-Tyr15) Antibody
Philip M. KUBARA, Sophie KERN´EIS-GOLSTEYN, Aur´elie STUD´ENY, Brittany B. LANSER, et al. (2012) Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents. Biochem. J. 446:373–381
11245
p44/42 MAP Kinase (Phospho-Thr202) Antibody
Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press,
11246
P-ERK
Jin-Hang Gao, Shi-Lei Wen, Wen-Juan Yang, Yao-Yao Lu, et al. (2013) Celecoxib Ameliorates Portal Hypertension of the Cirrhotic Rats through the Dual Inhibitory Effects on the Intrahepatic Fibrosis and Angiogenesis. PLoS ONE 8(7): e69309. doi:10.1371/journal.pone.0069309
11249
SAPK/JNK (Phospho-Thr183) Antibody
Anastasia F. Thévenina, Chati L. Zonya, Brian J. Bahnsona , et al (2010)Activation by phosphorylation and purification of human c-Jun N-terminal Kinase (JNK) isoforms in milligram amounts. Protein Expression and Purification, 75( 2) ,138-146
11249
SAPK/JNK(Phospho-Thr183) Antibody
Peng Jiao • Yun-Sheng Zhou • Juan-Xia Yang • Ya-Li Zhao • Qiang-Qiang Liu • Chuang Yuan • Feng-Ze Wang, MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death,Mol Cell Biochem DOI 10.1007/s11010-013-1737-0
11252
P38 MAPK(Phospho-Thr180) Antibody
Diansan Su, Yang Gu, Zhenhong Wang, Xiangrui Wang (2010) Lidocaine Attenuates Proinflammatory Cytokine Production Induced by Extracellular Adenosine Triphosphate in Cultured Rat Microglia. Anesthesia & Analgesia, 111 (3) 768-774
11253
P38 MAPK(Phospho-Tyr182) Antibody
RS Chen, YM Song, et al.(2008) Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway . Oncogene, 28, 599–609
11253
P38 MAPK(Phospho-Tyr182) Antibody
Diansan Su, Yang Gu, Zhenhong Wang, Xiangrui Wang (2010) Lidocaine Attenuates Proinflammatory Cytokine Production Induced by Extracellular Adenosine Triphosphate in Cultured Rat Microglia. Anesthesia & Analgesia, 111 (3) 768-774
11254
p70 S6 Kinase (Phospho-Thr421) Antibody
X Tang, X Zhou, K Zhou,et al.( 2009) Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1α protein.Acta Pharmacologica Sinica. 30 (5): 605–616
11260
NFκB-p65((phospho-Ser311) Antibody
Dan-Dan Shi†, Hu Shi†, Dan Lu, Rui Li, Yu Zhang and Jun Zhang, NDR1/STK38 potentiates NF-kB activation by its kinase activity, Cell Biochem Funct 2012; 30: 664–670
11268
Histone H2A.X(Phospho-Ser139) Antibody
Xiukun Cui a,1, Jing Zhang a,b,1, Rong Du c,1, Lei Wang a, Stephen Archacki d, Yuexuan Zhang a, Mingxiong Yuan a, Tie Ke a, Hui Li a, Duanzhuo Li a, Chang Li a, David Wan-Cheng Li e, Zhaohui Tang a,Zhan Yin, Mugen Liu, HSF4 is involved in DNA damage repair through regulation of Rad51,Biochimica et Biophysica Acta 1822 (2012) 1308–1315
11280
PKR(Phospho-Thr446) Antibody
Suzette Laing , Guohui Wang , Tamara Briazova ,et al (2010)Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues. Amerian Journal of Physiol Cell Physiol (June 16, 2010). doi:10.1152/ajpcell.00529.2009
11284
p70 S6 Kinase (Phospho-Ser424) Antibody
Dan Liu, Yi Huang, Bojiang Chen, Jing Zeng, et al. (2011) Activation of Mammalian Target of Rapamycin Pathway Confers Adverse Outcome in Nonsmall Cell Lung Carcinoma. DOI: 10.1002/cncr.25959
11290
PKR(Phospho-Thr451) Antibody
Suzette Laing , Guohui Wang , Tamara Briazova ,et al (2010)Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues. Amerian Journal of Physiol Cell Physiol (June 16, 2010). doi:10.1152/ajpcell.00529.2009
11294
MEK1(Phospho-Thr291) Antibody
Hanqian Xu, Gan Zhao, Xiaoxi Huang,et al (2010)CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. The Journal of Gene Medicine.12(1).97-106
11294
MEK1(Phospho-Thr291) Antibody
Akira Ikari, Kosuke Atomi, Keishi Kinjo, Yohei Sasaki, Junko Sugatani (2010) Magnesium deprivation inhibits a MEK–ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. Life Sciences. 86:766–773
11296
PKCd(Phospho-Ser645) Antibody
M. Uenoyama, S. Ogata, K. Nakanishi, F. Kanazawa, et al.(2010) Protein kinase C mRNA and protein expressions in hypobaric hypoxia-induced cardiac hypertrophy in rats. Acta Physiol. 198:431–440
11300
CREB(Phospho-Ser142) Antibody
Tomasz Boczek • Anna Kozaczuk • Bozena Ferenc •Michalina Kosiorek • Slawomir Pikula •Ludmila Zylinska, Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin, Mol Cell Biochem (2012) 360:89–102
11301
GSK3β(Phospho-Tyr216) Antibody
Hirakawa Hiroshi,Nakayama Toshiyuki, Shibata Kenichiro et al (2009) Association of cellular localization of glycogen synthase kinase 3beta in the digestive tract with cancer development. Oncology Reports, 22(3), 481-485
11301
GSK3b(Phospho-Tyr216) Antibody
Song Chen & Ai-ran Liu & Feng-mao An & Wen-bing Yao & Xiang-dong Gao, Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4, AGE (2012) 34:1211–1224
11321
Smad1(Phospho-Ser465) Antibody
Yamaguchi, J Zhu, T Yu, et al. (2007) Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.
11322
Smad2(Phospho-Ser467) Antibody
Xing-Yi Zhang, Bao-Rong Shen, Yu-Cheng Zhang, Xue-Jiao Wan, Qing-Ping Yao,et al (2013) Induction of Thoracic Aortic Remodeling by Endothelial-Specific Deletion of MicroRNA-21 in Mice. PLoS ONE. 8(3): e59002. doi:10.1371/journal.pone.0059002
11323
Smad2(Phospho-Thr220) Antibody
Xing-Yi Zhang, Bao-Rong Shen, Yu-Cheng Zhang, Xue-Jiao Wan, Qing-Ping Yao,et al (2013) Induction of Thoracic Aortic Remodeling by Endothelial-Specific Deletion of MicroRNA-21 in Mice. PLoS ONE. 8(3): e59002. doi:10.1371/journal.pone.0059002
11325
Smad3(Phospho-Ser425) Antibody
Mitsuko Moriguchi, Marie Yamada, Yasuo Miake and Mayu Koshika. (2012) Immunolocalization of Axin2 and p-Smad3 in Developing Rat Molar Germ.Journal of Hard Tissue Biology. 21[2] p.113 - 120
11327
TrkB(Phospho-Tyr515) Antibody
YeeWen Candace Wu, Rachel A. Hill, Maren Klug, Maarten van den Buuse (2012) Sex-specific and region-specific changes in BDNF–TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice. Brain Research.Volume 1452, Pages 10–17
11327
TrkB(Phospho-Tyr515) Antibody
Ning LI, Geng-tao LIU. (2010) The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta Pharmacologica Sinica. 31: 265–272
11328
TrkB(Phospho-Tyr705) Antibody
Rachel A. Hill, Maarten van den Buuse (2011) Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice. Brain Research, Volume 1384, Pages 51-60
11328
TrkB(Phospho-Tyr705) Antibody
Rachel A. Hill, Yee-Wen Candace Wu, Andrea Gogos, Maarten van den Buuse. (2013) Sex-denpendent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steriod hormones. Neurochem. 126: 389--399
11328
TrkB(Phospho-Tyr705) Antibody
R. A. Hill , Y. W. C. Wu, P. Kwek and M. van den Buuse,Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice,Journal of Neuroendocrinology, 2012, 24, 774–788
11330
a-catenin(Phospho-Ser641) Antibody
Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell 36(4):547-59 (Selected as the feature article by Mol Cell and highlighted in Cell and M.D. Anderson News Release), 11/2009. PMCID: PMC2784926.
11456
PKM2(phospho-Ser37) Antibody
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.
11507
cofilin1/cofilin2(phospho-Tyr88) Antibody
Xiaodong Li, Qiang Ke, Yanshu Li, Funan Liu, Ge Zhu, Feng Li ,DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1 ,The International Journal of Biochemistry& Cell Biology 42 (2010) 70–79 Contents lists
11517
HDAC4/HDAC5/HDAC9(phospho-Ser246/259/220) Antibody
Weiye Wang.(2010) A Novel Role of HDAC5 in Flow-Induced Gene Expression. Department of Pharmacology and Physiology School of Medicine and Dentistry University of Rochester Rochester
11545
FAK (phospho-Tyr576/Tyr577) Antibody
Z Zheng, Y Wei, et al.( 2008) Surface Characterization and Cytocompatibility of Three Chitosan/Polycation Composite Membranes for Guided Bone Regeneration.Journal of Biomaterials Applications,24:209-229
11545
FAK(phospho-Tyr576/Tyr577) Antibody
Jun-shan RUAN, Yu-ping LIU1, Lei ZHANG1, Ling-geng YAN, et al. (2012) Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the epithelial-mesenchymal transition. Acta Pharmacologica Sinica. 33: 1325–1331
11550
MDM2(phospho-Ser166) Antibody
Hetian Lei, Gisela Velez, and Andrius Kazlauskas. (2010) Pathological Signaling via Platelet-Derived Growth Factor Receptor Involves Chronic Activation of Akt and Suppression of p53. MOLECULAR AND CELLULAR BIOLOGY, May 2011, p. 1788–1799
11552
Sufu(Phospho-Ser342) Antibody
Yan Chen, Shen Yue, Lu Xie, Xiao-hong Pu,Tian Jin and Steven Y. Cheng, Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3 b Regulates Its Stability and Localization in the Primary Cilium, THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 15, pp. 13502–13511, April 15, 2011
11553
Cdc25B(Phospho-Ser149) Antibody
Jianying Xiao, Chao Liu, Junjie Hou, Cheng Cui,et al. (2011) Ser149 Is Another Potential PKA Phosphorylation Target of Cdc25B in G2/M Transition of Fertilized Mouse Eggs. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 12, pp. 10356–10366,
11553
Cdc25B(Phospho-Ser149) Antibody
XIAO Jian-Ying,LIU Chao,SUN Xiao-Han,YU Bing-Zhi,CDC25B Subcellular Localization Influences One-cell Stage Mouse Embryos[J] Chinese Journal of Biochemistry and Molecular Biol, 2013,V29(1): 33-41
11554
IL-10R subunit a(Phospho-Ser319/323) Antibody
Jiang H, Lu Y, Yuan L, Liu J (2011) Regulation of Interleukin-10 Receptor Ubiquitination and Stability by Beta-TrCP-Containing Ubiquitin E3 Ligase. PLoS ONE 6(11): e27464. doi:10.1371/journal.pone.0027464
11578
Niban(Phospho-Ser602) Antibody
Haitao Ji, Zhiyong Ding, DavidHawke, Dongming Xing, et al. (2012) AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EUROPEAN MOLECULAR BIOLOGY ORGANIZATION. VOL 13 NO 6:554-560
11578
Niban(Phospho-Ser602) Antibody
Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.
11581
P38 MAPK(Phospho-Thr180/Tyr182) antibody
Jia-Ping Ruan, M.D., Hong-Xing Zhang, M.D., Xian-Fu Lu, M.D., Yue-Peng Liu, M.D., et al.(2010) EphrinBs/EphBs Signaling Is Involved in Modulation of Spinal Nociceptive Processing through a Mitogen-activated Protein Kinases-dependent Mechanism. Anesthesiology. 112:1234-49
11581
P38 MAPK(Phospho-Thr180/Tyr182) antibody
Peter Schubert, Danielle Coupland, Brankica Culibrk, Raymond P. Goodrich, et al. (2013) Riboflavin and ultraviolet light treatment of platelets triggers p38MAPK signaling: inhibition significantly improves in vitro platelet quality after pathogen reduction treatment. TRANSFUSION. Volume **, ** **
11586
Bub3 (Phospho-Tyr207) Antibody
Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
(2014), http://dx.doi.org/10.1016/j.molcel.2013.11.00111889
phospho‐ERK1/2
Yinbo Niu, Yuhua Li, Haitao Huang, Xianghe Kong, et al. (2011) Asperosaponin VI, A Saponin Component from Dipsacus asper Wall, induces Osteoblast Differentiation through Bone Morphogenetic Protein‐2/p38 and Extracellular Signal‐regulated Kinase 1/2 Pathway. Phytother. Res. 25: 1700–1706
20184
p53(Ab-9) Antibody
Peng Gao, Fei Zhai, Lei Guang, Jie Zheng. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. ONCOLOGY LETTERS 2: 123-128
21001
c-Jun (Ab-63) Antibody
kira Ikari,Hayato Sawada, et al. (2008)Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A Naunyn-Schmiedeberg's.Archives of Pharmacology, 377(4-6):333-43.
21002
GSK3β (Ab-9) Antibody
Cong REN, Jia-Mou LI, Xin LIN (2010)LIPUS Enhance Elongation of Neurites in Rat Cortical Neurons through Inhibition of GSK-3β. Biomedical and Environmental Sciences, Volume 23, Issue 3, Pages 244-249
21002
GSK3b(Ab-9) Antibody
Yu-fei Pan, Li-wei Dong, Min Wang, Guang-zhen Yang, et al. (2013) Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation. Eur. J. Immunol. 43: 1598–1607
21002
GSK3b(Ab-9) Antibody
Lei Hana, Yang Yanga, Xiao Yuea, Kai Huanga, et al. (2010) Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. BRAIN RESEARCH 1366:9–17
21002
GSK3b(Ab-9) Antibody
Wen-Fei Tan, Xue-Zhao Cao, Jun-KeWang, Huang-Wei Lv, et al. (2010) Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. Clinical and Experimental Pharmacology and Physiology. 37:1010–1015
21002
GSK3b(Ab-9) Antibody
Ramiro E. Toribio, Holly A. Brown, Chad M. Novince, Brandlyn Marlow, et al.(2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. The FASEB Journal. Vol. 24 pp.1947-1957
21002
GSK3b(Ab-9) Antibody
Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83
21003
c-Jun (Ab-73) Antibody
kira Ikari,Hayato Sawada, et al. (2008) Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A Naunyn-Schmiedeberg's.Archives of Pharmacology, 377(4-6):333-43.
21005
PDK1(Ab-241) Antibody
Dan Liu, Yi Huang, Bojiang Chen, Jing Zeng, et al. (2011) Activation of Mammalian Target of Rapamycin Pathway Confers Adverse Outcome in Nonsmall Cell Lung Carcinoma. DOI: 10.1002/cncr.25959
21005
PDK1(Ab-241) Antibody
Yongheng Cao1,2,11, Masanori Nakata3, Shiki Okamoto4, Eisuke Takano3, Toshihiko Yada3, Yasuhiko Minokoshi4, Yukio Hirata5, Kazunori Nakajima5, Kristy Iskandar1, Yoshitake Hayashi1, Wataru Ogawa6, Gregory S. Barsh7, Hiroshi Hosoda8, Kenji Kangawa8, Hiroshi Itoh9, Tetsuo Noda10, Masato Kasuga7,11, Jun Nakae, PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure, April 2011 | Volume 6 | Issue 4 | e18324
21006
Raf1(Ab-259) Antibody
Zhi-Xin Qiu, Lei Wang,Juan Han, Dan Liu, et al.(2012) Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer. Cancer Sci. vol. 103 no. 10 pp. 1774–1779
21010
NFkB-p65(Ab-254) Antibody
Naina Shah, Montserrat Montes de Oca, Maria Jover-Cobos, Ken-ichi Tanamoto, et al.(2013) Role of Toll-Like Receptor 4 in Mediating Multiorgan Dysfunction in Mice With Acetaminophen Induced Acute Liver Failure. LIVER TRANSPLANTATION 19:751–761
21011
NFκB-p65(Ab-276) Antibody
S. Clockaerts, Y.M. Bastiaansen-Jenniskens, C. Feijt, et al (2011) Peroxisome proliferator activated receptor alpha activation decreases inflammatory and destructive responses in osteoarthritic cartilage. Osteoarthritis and Cartilage, Volume 19, Issue 7, July 2011, Pages 895-902
21011
NFkB-p65(Ab-276) Antibody
Gerben M. van Buul, Wendy L.M. Koevoet, Nicole Kops, P. Koen Bos, et al.(2011) Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes. Am J Sports Med. 39: 2362-2370
21014
NFkB-p65(Ab-536) Antibody
Naina Shah, Dipok Dhar, Fatma El Zahraa Mohammed1, Abeba Habtesion, et al. (2012) Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression. Journal of Hepatology. vol. 56:1047–1053
21021
c-Jun (Ab-91) Antibody
kira Ikari,Hayato Sawada, et al. (2008) Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A Naunyn-Schmiedeberg's.Archives of Pharmacology, 377(4-6):333-43.
21022
c-Jun(Ab-93) Antibody
Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D.Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215
21034
Myc(Ab-58) Antibody
S.Y. Liu, Y.L. Ma, E.H.Y. Lee. (2013) NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.Neuropharmacology. 65:101-113
21035
Myc(Ab-358) Antibody
S.Y. Liu, Y.L. Ma, E.H.Y. Lee. (2013) NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.Neuropharmacology. 65:101-113
21036
Myc(Ab-373) Antibody
S.Y. Liu, Y.L. Ma, E.H.Y. Lee. (2013) NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.Neuropharmacology. 65:101-113
21044
STAT1(Ab-701) Antibody
Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125
21045
STAT3 (Ab-705) Antibody
Takuya Takeichi, Kazumitsu Sugiura, Yoshinao Muro, et al (2010)Overexpression of LEDGF/DFS70 Induces IL-6 via p38 Activation in HaCaT Cells, Similar to that Seen in the Psoriatic Condition. Journal of Investigative Dermatology 130, 2760-2767
21045
STAT3 (Ab-705) Antibody
Emilio García-Prieto, Adrián González-López,, Sandra Cabrera, et al (2010)Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10. PloS one, 5(10): e13242.
21045
STAT3(Ab-705) Antibody
Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125
21046
STAT3(Ab-727) Antibody
Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125
21046
STAT3(Ab-727) Antibody
Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, et al. (2011) Canonical Notch Pathway Protects Hepatocytes from Ischemia/Reperfusion Injury in Mice by Repressing Reactive Oxygen Species Production Through JAK2/STAT3 Signaling. HEPATOLOGY, Vol. 54, No. 3, 979-988
21047
STAT4(Ab-693) Antibody
Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125
21049
STAT5a(Ab-780) Antibody
Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125
21051
STAT6(Ab-645) Antibody
Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125
21052
CREB (Ab-133) Antibody
Tomasz Boczek, Anna Kozaczuk, Bozena Ferenc, Michalina Kosiorek and Slawomir Pikula, et al.Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin.Molecular and Cellular Biochemistry, 12 September 2011
21053
ATF4 (Ab-245) Antibody
Hong-Li Wu, Yu-Hua Li, Yan-Hua Lin, et al. (2008) Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction.Cardiovasc Res, 81:148-158
21054
Akt (Ab-473) Antibody
Young Yil Bahk, Ick-Hyun Cho, Tong Soo Kim. A Cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts.Biochemical and Biophysical Research Communications, 377:1199–1204.
21054
Akt (Ab-473) Antibody
Jing Zhang, Osamu Yamada, Yoshihisa Matsushita, ect.(2009) Transactivation of human osteopontin promoter by human T-cell leukemia virus type 1-encoded Tax proteinLeukemia Research in press.
21054
Akt (Ab-473) Antibody
Seyoon Kim, Yong Zu Lee, Yu Sam Kim,et al (2008)A Proteomic approach for protein-profiling the oncogenic ras induced transformation (H-, K-, and N-Ras) in NIH/3T3 mouse embryonic fibroblasts. Proteomics, 8 (15), 3082 - 3093
21054
Akt (Ab-473) Antibody
Hyun Seung Ban, Masaharu Uno, Hiroyuki Nakamura, et al (2010)Suppression of hypoxia-induced HIF-1 [alpha] accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. Cancer letters ,296,( 1) 17-26
21054
Akt (Ab-473) Antibody
Yingjia Guo, Tong Yang, Jun Lu, et al (2011) Rb1 postconditioning attenuates liver warm ischemia–reperfusion injury through ROS-NO-HIF pathway. Life Sciences, Volume 88, Issues 13-14, Pages 598-605
21054
Akt(Ab-473) Antibody
Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411
21054
Akt(Ab-473) Antibody
Ze-yang Ding, Guan-nan Jin, Hui-fang Liang, Wei Wang, et al. (2013) Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Cellular Signalling. 25:1981–1992
21054
Akt(Ab-473) Antibody
Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16
21054
Akt(Ab-473) Antibody
Chen, Song,(2012) The role of cad,flash and fam129b in cancer cell survial and apoptosis. Wayne State University Dissertations. Paper428
21054
Akt(Ab-473) Antibody
Heng-Chao Yu, Hong-Yan Qin, Fei He, Lin Wang, et al. (2011) Canonical Notch Pathway Protects Hepatocytes from Ischemia/Reperfusion Injury in Mice by Repressing Reactive Oxygen Species Production Through JAK2/STAT3 Signaling. HEPATOLOGY, Vol. 54, No. 3, 979-988
21054
Akt(Ab-473) Antibody
Massimo Nabissi, Maria Beatrice Morelli1, Consuelo Amantini, Valerio Farfariello1, et al. (2010) TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis vol.31 no.5 pp.794–803
21054
Akt(Ab-473) Antibody
Ramiro E. Toribio, Holly A. Brown, Chad M. Novince, Brandlyn Marlow, et al.(2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. The FASEB Journal. Vol. 24 pp.1947-1957
21054
Akt(Ab-473) Antibody
Hu Ma, Quan Yao, An-Mei Zhang, Sheng Lin, Xin-Xin Wang, Lei Wu, Jian-Guo Sun,and Zheng-Tang Chen(2011)The Effects of Artesunate on the Expression of EGFR and ABCG2 in A549 Human Lung Cancer Cells and a Xenograft Model. Molecules 2011, 16, 10556-10569; doi:10.3390/molecules161210556
21054
Anti-STAT3
Heng-Fei Luan1*, Zhi-Bin Zhao1*, Qi-Hong Zhao2, Pin Zhu1, Ming-Yu Xiu1 and Yong Ji, Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway
21054
Akt(Ab-473) Antibody
Hongxia Zhanga,1, Junjie Houb,1, Ruina Cuia, Xuejiang Guoc, Zhimin Shia, Fuquan Yangb, Jiayin Daia, Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters 218 (2013) 61– 69
21054
Akt(Ab-473) Antibody
Song Chen, Hedeel Guy Evans and David R.,Evans, FAM129B/MINERVA, a Novel Adherens Junction-associated Protein, Suppresses Apoptosis in HeLa Cells, J. Biol. Chem. 2011, 286:10201-10209.
21054
Akt(Ab-473) Antibody
Shen J, et al., The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy, Biomaterials (2013) Volume 35, Issue 1, January 2014, Pages 316–326
21055
Akt (Ab-308) Antibody
Nabissi Massimo,Morelli Maria Beatrice,Amantini Consuelo, et al (2010) TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis. 0: bgq019v1-bgq019
21055
Akt(Ab-308) Antibody
Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411
21055
Akt(Ab-308) Antibody
Hyun Seung Ban, Masaharu Uno, Hiroyuki Nakamura. (2010) Suppression of hypoxia-induced HIF-1a accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. Cancer Letters. 296:17–26
21055
Akt(Ab-308) Antibody
Yingjia Guo, Tong Yang, Jun Lu, Shengfu Li, et al. (2011) Rb1 postconditioning attenuates liver warm ischemia–reperfusion injury through ROS-NO-HIF pathway. Life Sciences. 88:598–605
21055
Akt(Ab-308) Antibody
Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83
21055
Akt(Ab-308) Antibody
Hongxia Zhanga,1, Junjie Houb,1, Ruina Cuia, Xuejiang Guoc, Zhimin Shia, Fuquan Yangb, Jiayin Daia, Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity,Toxicology Letters 218 (2013) 61– 69
21057
PTEN(Ab-370) Antibody
Zhi Li & Gong Xiang Liu & Yu Lan Liu & Xi Chen & Xiao Li Huang & Hua Tian Gan, Effect of adenovirus-mediated PTEN gene on ulcerative colitis-associated colorectal cancer, Int J Colorectal Dis (2013) 28:1107–1115
21059
BCL-2(Ab-56) Antibody
Wei-Jun Pang,Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-she Yang (2013) Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Mol Biol Rep. 40:129–139
21060
BCL-2(Ab-70) Antibody
Wei-Jun Pang,Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-she Yang (2013) Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Mol Biol Rep. 40:129–139
21064
BAD(Ab-155) Antibody
Yi Huang • Dan Liu • Bojiang Chen • Jing Zeng • Lei Wang • Shangfu Zhang • Xianming Mo • Weimin Li, Loss of Bad expression confers poor prognosis in non-small cell lung cancer,Med Oncol (2012) 29:1648–1655
21065
Estrogen Receptor-α (Ab-104) Antibody
Yamaguchi, J Zhu, T Yu, et al. (2007) Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.
21066
Estrogen Receptor-α (Ab-106) Antibody
Yamaguchi, J Zhu, T Yu, et al. (2007)Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their differentiation state.Cell Biology International, 31(6):638-644.
21070
HER2(Ab-877) Antibody
Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411
21071
HER2(Ab-1221/1222) Antibody
Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411
21072
HER2(Ab-1248) Antibody
Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant
Phenotype of Colorectal Cancer Cells. Lipids 47:403–41121072
HER2(Ab-1248) Antibody
Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83
21073
EGFR(Ab-1070) Antibody
Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895
21074
EGFR(Ab-1092) Antibody
Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895
21079
VEGFR2(Ab-951) Antibody
Qi Zhao, TakakoYokozawab, NorikoYamabeb, et al (2010) Kangen-karyu improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain. Journal of Ethnopharmacology,Article in Press
21079
VEGFR2(Ab-951) Antibody
Qi Zhao, Takako Yokozawa, Koichi Tsuneyama, Ken Tanaka and Takeshi Miyata, et al.Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain.Chinese Medicine, 2011, Volume 6, Number 1, 33
21079
VEGFR2(Ab-951) Antibody
Qi Zhao, Yimin Niu, Kinzo Matsumoto1, Koichi Tsuneyama, et al. (2012) Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complementary and Alternative Medicine. 12:188
21080
IGF-1R(Ab-1161) Antibody
Hossein Haghir, Abd-Al-Rahim Rezaee, Hossein Nomani, Mojtaba Sankian, et al.(2013) Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol. 33:369–377
21080
IGF-1R(Ab-1161) Antibody
TAKETSUGU YAMAMOTO, TAKASHI OSHIMA, KAZUE YOSHIHARA, TEPPEI NISHI, HIROMASA ARAI,KENJI INUI, TAKESHI KANEKO, AKINORI NOZAWA, HIROYUKI ADACHI, YASUSHI RINO, MUNETAKA MASUDA and TOSHIO IMADA(2012)Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer,EXPERIMENTAL AND THERAPEUTIC MEDICINE 3: 797-802, 2012
21081
IGF-1R(Ab-1165/1166) Antibody
Chao Han, Remi Quirion, Wenhua Zheng et al (2011) Glutamate attenuates IGF-1 receptor signaling via NR2B containing NMDA receptors and neuronal nitric oxide synthase. Biochemical and Biophysical Research Communications, In Press,
21081
IGF-1R(Ab-1165/1166) Antibody
Hossein Haghir, Abd-Al-Rahim Rezaee, Hossein Nomani, Mojtaba Sankian, et al.(2013) Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol. 33:369–377
21083
p53(Ab-6) Antibody
Haitao Ji, Zhiyong Ding, DavidHawke, Dongming Xing, et al. (2012) AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EUROPEAN MOLECULAR BIOLOGY ORGANIZATION. VOL 13 NO 6:554-560
21083
p53(Ab-6) Antibody
Peng Gao, Fei Zhai, Lei Guang, Jie Zheng. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. ONCOLOGY LETTERS 2: 123-128
21083
p53(Ab-6) Antibody
Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.
21085
p53(Ab-15) Antibody
Peng Gao, Fei Zhai, Lei Guang, Jie Zheng. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. ONCOLOGY LETTERS 2: 123-128
21086
p53(Ab-18) Antibody
Peng Gao, Fei Zhai, Lei Guang, Jie Zheng. (2011) Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21. ONCOLOGY LETTERS 2: 123-128
21090
p53(Ab-46) Antibody
Lei Zhang, Junshan Ruan, Linggeng Yan, Weidong Li, et al.(2012) Xanthatin Induces Cell Cycle Arrest at G2/M Checkpoint and Apoptosis via Disrupting NF-κB Pathway in A549 Non-Small-Cell Lung Cancer Cells. Molecules. 17:3736-3750
21103
β-Catenin(Ab-41/45) Antibody
Qingsong Wang, Jintang He, Lingyao Meng,et al.(2010)A Proteomics Analysis of Rat Liver Membrane Skeletons: The Investigation of Actin- and Cytokeratin-Based Protein Components. Journal of Proteome Research, 9, 22–29
21103
β-Catenin(Ab-41/45) Antibody
Chih-Kai Liao, Seu-Mei Wang, Yuh-Lien Chen, et al (2010) Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. The International Journal of Biochemistry & Cell Biology,Volume 42, Issue 5, May 2010, Pages 762–770
21106
ICAM-1(Ab-512) Antibody
Oualid Sbai, Adlane Ould-Yahoui, Lotfi Ferhat,et al.(2009)Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes.Glia, 58( 3), 344 – 366
21106
ICAM-1(Ab-512) Antibody
Xi-Jin Wang, Shi Zhang, Zhi-Qiang Yan, et al(2011) Impaired CD200–CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase, and p38 MAPK. Free Radical Biology and Medicine, Volume 50, Issue 9, Pages 1094-1106
21109
Rb(Ab-807) Antibody
Hui Xu1, Yaping Yan, Mark S. Williams, Gregory B. Carey, et al. (2010) MS4a4B, a CD20 Homologue in T Cells, Inhibits T Cell Propagation by Modulation of Cell Cycle. PLoS ONE 5(11): e13780. doi:10.1371/journal.pone.0013780
21110
Rb(Ab-780)Antibody
Xueting Cai, Tingmei Ye, Chao Liu, et al (2011) Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicology in Vitro, Volume 25, Issue 7, Pages 1385-1391
21110
Rb(Ab-780) Antibody
Heidi Braumuller, ThomasWieder, Ellen Brenner, Sonja Aßmann, et al. (2013) T-helper-1-cell cytokines drive cancer into senescence. NATURE.494:361-366
21111
CDK2 (Ab-160) Antibody
Song Chen, Hedeel Guy Evans and David R.Evans (2010)FAM129B/minerva, a novel adherens junction associated protein suppresses apoptosis in hela cells. Journal of Biological Chemistry, 2010 - ASBMB
21111
CDK2(Ab-160) Antibody
Chen, Song,(2012) The role of cad,flash and fam129b in cancer cell survial and apoptosis. Wayne State University Dissertations. Paper428
21119
JAK1 (Ab-1022) Antibody
Dan Liu, Yi Huang, Jing Zeng, Bojiang Chen and Na Huang, et al.Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. Journal of Cancer Research and Clinical Oncology, 2011, Volume 137, Number 11, Pages 1629-164
21125
ASK1 (Ab-83) Antibody
Min Yang, Mingcan Yu, Dongyin Guan,et al(2010) ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. Journal of Cellular Biochemistry,110(3), 581 - 588
21127
LIMK1 (Ab-508) Antibody
Li, X., Ke, Q., Li, Y., Liu, F., Zhu, G., & Li, F., et al. (2008)DGCR6L, A Novel PAK4 Interaction Protein, Regulates PAK4-mediated migration of Human Gastric Cancer Cell via LIMK1 International Journal of Biochemistry and Cell Biology, 42: 70–79
21129
PLCγ1 (Ab-783) Antibody
Cheng-Ying Hsieh, Chien-Liang Liu, Ming-Jen Hsu ,et al(2010)Inhibition of vascular smooth muscle cell proliferation of vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: Pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation. Free Radical Biology and Medicine, Article in Press, Accepted Manuscript
21129
PLCg1(Ab-783) Antibody
Yu-fei Pan, Li-wei Dong, Min Wang, Guang-zhen Yang, et al. (2013) Signal regulatory protein α negatively regulates mast-cell activation following FcεRI aggregation. Eur. J. Immunol. 43: 1598–1607
21130
AMPKa1(Ab-487) Antibody
Yan-Na Huang, Jian-Hua Qi, Lan Xiang , Yi-Zhen Wang(2012)Construction of adiponectin-encoding plasmid DNA and overexpression in mice
in vivo.Gene 502 (2012) 87–9321134
ASK1 (Ab-966) Antibody
Min Yang, Mingcan Yu, Dongyin Guan,et al(2010) ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. Journal of Cellular Biochemistry,110(3), 581 - 588
21137
Histone H3.1(Ab-10) Antibody
Guo-Dong Li , Xi Zhang , Rong Li , et al. (2008)CHP2 activates the calcineurin/NFAT signaling pathway and enhances the oncogenic potential of HEK293 cells JBC, 283 (47): 32660–32668
21137
Histone H3.1(Ab-10) Antibody
Chao Yu, Ting Shan, Aiwen Feng, et al(2011) Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-κB signaling pathway.Fitoterapia, Volume 82, Issue 4, June 2011, Pages 709-715
21137
Histone H3.1(Ab-10) Antibody
MIN HUANG, JING ZHOU, LIQING BI, QIAN ZHANG, SUMING ZHOU (2012) Anti-Toll-like receptor 2 antibody, T2.1, reduces tumor necrosis factor α and interleukin-6 release and inhibits nuclear factor κB expression in bacterial lipoprotein stimulated THP-1 cells.Centr Eur J Immunol. 37 (1): 6-10
21137
Histone H3.1(Ab-10) Antibody
Chen S, Evans HG, Evans DR (2012) FLASH Knockdown Sensitizes Cells To Fas-Mediated Apoptosis via Down-Regulation of the Anti-Apoptotic Proteins,MCL-1 and Cflip Short. PLoS ONE 7(3): e32971. doi:10.1371/journal.pone.0032971
21137
Histone H3.1(Ab-10) Antibody
Yingyi Zhang, Yu Zhao, Hang Li, Yinghui Li, et al.(2013) Cancer Cells Phosphorylation of Both Proteins in Breast on Interacting with c-Fos and Hepatitis B X-interacting Protein Depends The Nuclear Import of Oncoprotein. J. Biol. Chem.10.1074/jbc.M113.458638
21137
Histone H3.1(Ab-10) Antibody
Chen, Song,(2012) The role of cad,flash and fam129b in cancer cell survial and apoptosis. Wayne State University Dissertations. Paper428
21137
Histone H3.1(Ab-10) Antibody
C.Y. MA, C.P. ZHANG, L.P. ZHONG, H.Y. PAN1, et al. (2011) Decreased expression of profilin 2 in oral squamous cell carcinoma and its clinicopathological implications. ONCOLOGY REPORTS 26: 813-823
21137
Histone H3.1(Ab-10) Antibody
Xiangyang Yao, Fenfen Zhu, Zhihui Zhao, Chang Liu, et al. (2011) Arctigenin Enhances Chemosensitivity of Cancer Cells to Cisplatin Through Inhibition of the STAT3 Signaling Pathway. Journal of Cellular Biochemistry 112:2837–2849
21137
Histone H3.1(Ab-10) Antibody
Zenglin Liao†, Jiajia Dong†, Wei Wu, Ting Yang, Tao Wang, Lingli Guo, Lei Chen, Dan Xu and Fuqiang Wen, Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway, Liao et al. Respiratory Research 2012, 13:110
21138
FKHR(Ab-256) Antibody
Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16
21142
HDAC5 (Ab-498) Antibody
Pang J, Yan C, Natarajan K, et al. (2008) GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5):892-8.
21142
HDAC5 (Ab-498) Antibody
Weiye Wang, Chang Hoon Ha, Bong Sook Jhun,et al(2010)Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Blood, 115( 14), 2971-2979.
21144
HSP27(Ab-15) Antibody
Wenbo Ma1, Yan Teng1, Hui Hua, Jinlin Hou1, Ting Luo and Yangfu Jiang (2013) Upregulation of heat shock protein 27 confers resistance
to actinomycin D-induced apoptosis in cancer cells.FEBS Journal. 10 :1-1321147
ATM(Ab-1981) Antibody
Hiroaki Inaba, Masae Kuboniwa, Hideyuki Sugita, Richard J. Lamont and Atsuo Amano, Identification of Signaling Pathways Mediating Cell Cycle Arrest and Apoptosis Induced by Porphyromonas gingivalis in Human Trophoblasts, Infect. Immun. 2012, 80(8):2847. DOI: 10.1128/IAI.00258-12.
21149
p21Cip1(Ab-145) Antibody
Masahiko Kanehira, Toshiaki Kikuchi, Shinya Ohkouchi, Taizou Shibahara, et al. (2012) Targeting Lysophosphatidic Acid Signaling Retards Culture-Associated Senescence of Human Marrow Stromal Cells.PLoS ONE 7(2): e32185. doi:10.1371/journal.pone.0032185
21150
p27Kip1 (Ab-10)Antibody
Fan Yang, Yu-Ping Xu , et al(2009).Cloning and Characterization of a Novel Intracellular Protein p48.2 that Negatively Regulates Cell Cycle Progression.The International Journal of Biochemistry & Cell Biology, 41 (11): 2240–2250
21160
PAK1(Ab-212) Antibody
Bingyuan Wang1†, Wei Ma1,3†, Xiaoling Xu1,2, Chao Wang1, Yubo Zhu1, Na An1, Lei An1, Zhonghong Wu and Jianhui Tian1 , Phosphorylation of histone H3 on Ser10 by auto-phosphorylated PAK1 is not essential for chromatin condensation and meiotic progression in porcine oocytes, Wang et al. Journal of Animal Science and Biotechnology 2013, 4:13
21163
cdc25A(Ab-76) Antibody
XIAO Jian-Ying,LIU Chao,SUN Xiao-Han,YU Bing-Zhi,CDC25B Subcellular Localization Influences One-cell Stage Mouse Embryos[J] Chinese Journal of Biochemistry and Molecular Biol, 2013,V29(1): 33-41
21164
cofilin(Ab-3) Antibody
Lijun Zhang, Jun Luo, Ping Wan, Jing Wu, et al. (2011) Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. Development. 138:455-464
21166
IRS-1 (Ab-312) Antibody
Daisuke Ekuni , Takaaki Tomofuji , Koichiro Irie, et al (2010) Effects of periodontitis on aortic insulin resistance in an obese rat model. Laboratory Investigation, doi:10.1038
21168
Src (Ab-529) Antibody
Yanhua Zheng, Yan Xia, Xiang Gao, Zhimin Lu, et al. (2009) Molecular Cell,35:11–25FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST.
21170
Anti-eNOS antibody
Jian Jiao, Hong Wang, Wei Lou, et al (2011) Regulation of ciliary beat frequency by the nitric oxide signaling pathway in mouse nasal and tracheal epithelial cells. Experimental Cell Research, Volume 317, Issue 17, Pages 2548-2553
21177
STAT1(Ab-727) Antibody
Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125
21187
FLT3 (Ab-591) Antibody
Nana Ninagawa, Rumi Murakami, Eri Isobe,et al (2011) Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits. Differentiation, Volume 82, Issue 3, Pages 153-164
21193
EGFR(Ab-678) Antibody
Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895
21194
EGFR(Ab-693) Antibody
Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895
21196
Ephrin-B2(Ab-330) Antibody
Ramiro E. Toribio, Holly A. Brown, Chad M. Novince, Brandlyn Marlow, et al.(2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. The FASEB Journal. Vol. 24 pp.1947-1957
21209
Pyk2(Ab-402) Antibody
Rui-Fang Liu a,b, Xiao Xu a,b, Jian Huang a,b, Qian-Lan Fei b, Fei Chen b, Yan-Dong Li b, Ze-Guang Han, Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2,Cancer Letters 329 (2013) 164–173
21211
β-Catenin (Ab-33) Antibody
Qingsong Wang, Jintang He, Lingyao Meng,et al.(2010)A Proteomics Analysis of Rat Liver Membrane Skeletons: The Investigation of Actin- and Cytokeratin-Based Protein Components. Journal of Proteome Research, 9, 22–29
21211
β-Catenin (Ab-33) Antibody
Chih-Kai Liao, Seu-Mei Wang, Yuh-Lien Chen, et al (2010) Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. The International Journal of Biochemistry & Cell Biology,In press
21211
β-Catenin (Ab-33) Antibody
Lei Hana, Yang Yanga, Xiao Yue, et al (2010)Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of [beta]-catenin-mediated transcription. Brain Research, 1366, 9-17
21212
β-Catenin (Ab-37) Antibody
Qingsong Wang, Jintang He, Lingyao Meng,et al.(2010)A Proteomics Analysis of Rat Liver Membrane Skeletons: The Investigation of Actin- and Cytokeratin-Based Protein Components. Journal of Proteome Research, 9, 22–29
21212
β-Catenin (Ab-37) Antibody
Chih-Kai Liao, Seu-Mei Wang, Yuh-Lien Chen, et al (2010) Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. The International Journal of Biochemistry & Cell Biology,In press
21213
EGFR(Ab-1172) Antibody
Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895
21213
EGFR(Ab-1172) Antibody
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.
21220
Met (Ab-1234) Antibody
Na Li, Hanjiang Fu, Yi Tie, et al. (2008) miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells.Cancer Letters, 275(1):44-53
21220
Met(Ab-1234) Antibody
Luo W, Huang B, Li Z, Li H, Sun L, et al. (2013) MicroRNA-449a Is Downregulated in Non-Small Cell Lung Cancer and Inhibits Migration and Invasion by Targeting c-Met. PLoS ONE 8(5): e64759
21221
EGFR(Ab-1197) Antibody
Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang,et al(2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology. 44 : 886– 895
21223
IRS-1(Ab-636) Antibody
Daisuke Ekuni , Takaaki Tomofuji , Koichiro Irie, et al (2010) Effects of periodontitis on aortic insulin resistance in an obese rat model. Laboratory Investigation, doi:10.1038
21224
IRS-1(Ab-639) Antibody
Daisuke Ekuni , Takaaki Tomofuji , Koichiro Irie, et al (2010) Effects of periodontitis on aortic insulin resistance in an obese rat model. Laboratory Investigation, doi:10.1038
21228
IRS-1 (Ab-307) Antibody
Daisuke Ekuni , Takaaki Tomofuji , Koichiro Irie, et al (2010) Effects of periodontitis on aortic insulin resistance in an obese rat model. Laboratory Investigation, doi:10.1038
21232
c-Kit(Ab-721) Antibody
Shinka Miyamoto, Nanako Kawaguchi, Georgina M. Ellison, Rumiko Matsuoka, et al. (2010) Characterization of Long-Term Cultured c-kit+ Cardiac Stem Cells Derived From Adult Rat Hearts. STEM CELLS AND DEVELOPMENT. Volume 19, Number 1
21234
BRCA1(Ab-1423) Antibody
Bo Xiong, Sen Li, Jun-Shu Ai, et al. (2008) BRCA1 Is Required for Meiotic Spindle Assembly and Spindle Assembly Checkpoint Activation in Mouse Oocytes. .Biol Reprod, 79, 718–726
21236
CDC2(Ab-15) Antibody
Qi Yao, Hui Li, Bing-Qian Liu, Xin-Yun Huang, et al. (2013) SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 31, pp. 27342–27349
21236
CDC2(Ab-15) Antibody
Philip M. KUBARA, Sophie KERN´EIS-GOLSTEYN, Aur´elie STUD´ENY, Brittany B. LANSER, et al. (2012) Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents. Biochem. J. 446:373–381
21239
HSP27(Ab-78) Antibody
Wenbo Ma1, Yan Teng1, Hui Hua, Jinlin Hou1, Ting Luo and Yangfu Jiang (2013) Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells.FEBS Journal. 10 :1-13
21240
HSP27(Ab-82) Antibody
Wenbo Ma1, Yan Teng1, Hui Hua, Jinlin Hou1, Ting Luo and Yangfu Jiang (2013) Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells.FEBS Journal. 10 :1-13
21241
SAPK/JNK(Ab-183) Antibody
Anastasia F. Thévenin, Chati L. Zony, Brian J. Bahnson, Roberta F. Colman.(2011) Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts. Protein Expression and Purification. 75: 138–146
21245
p38 MAPK (Ab-182) Antibody
Yi-Wen Gu, Dian-San Su, Jie Tian et al. (2008)Neuroscience Letters, 431(2):129-34. Attenuating phosphorylation of p38 MAPK in the activated microglia: A new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats.
21245
p38 MAPK (Ab-182) Antibody
Diansan Su, Yang Gu, Zhenhong Wang, Xiangrui Wang (2010) Lidocaine Attenuates Proinflammatory Cytokine Production Induced by Extracellular Adenosine Triphosphate in Cultured Rat Microglia. Anesthesia & Analgesia, 111 (3) 768-774
21249
Tau(Ab-212) Antibody
Ramiro E. Toribio, Holly A. Brown, Chad M. Novince, Brandlyn Marlow, et al.(2010) The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. The FASEB Journal. Vol. 24 pp.1947-1957
21257
MARCKS (Ab-162) Antibody
Maria C. Olianas, Simona Dedoni, Pierluigi Onali (2011) Signaling pathways mediating phosphorylation and inactivation of glycogen synthase kinase-3β by the recombinant human δ-opioid receptor stably expressed in Chinese hamster ovary cells. Neuropharmacology, Volume 60, Issues 7-8, Pages 1326-1336
21260
Histone H2A.X (Ab-139) Antibody
Jennifer S. Dickey,Christophe E. Redon,Asako J. Nakamura, et al (2009) H2AX: functional roles and potential applications.Chromosoma 118:683–692
21260
Histone H2A.X(Ab-139) Antibody
Xiaohan Li, Takeshi Nishida, Akira Noguchi, et al (2010) Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma, Journal of Cancer Research and Clinical Oncology, 136( 10), 1573-1583
21260
Histone H2A.X(Ab-139) Antibody
Xiao-han Li, Keiji Kikuchi, Yang Zheng, et al (2011) Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma. Oral Oncology, Volume 47, Issue 3, March 2011, Pages 217-223
21260
Histone H2A.X(Ab-139) Antibody
Teng Li, Jing Hu, Gong-Hao He, Yun Li, Chu-Chao Zhu, et al (2012) Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes. Biochimica et Biophysica Acta. 1822:301–313
21260
Histone H2A.X(Ab-139) Antibody
Yan Qing • Yanfang Liang • Qingqing Du •Pan Fan • Hangong Xu • Yiping Xu • Nian Shi,Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-jB and MAPKs signaling pathways,Arch Toxicol (2013) 87:1273–1285
21264
Cortactin(Ab-466) Antibody
Nobuo Terada, Nobuhiko Ohno, Sei Saitoh, et al (2009) Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells.Cell Tissue Res: 337:91–102
21271
eIF2α (Ab-51) Antibody
Hong-Li Wu, Yu-Hua Li, Yan-Hua Lin, et al. (2008) Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction.Cardiovasc Res, 81:148-158
21274
Integrin b3(Ab-785) Antibody
Ruifei Wang, Jiajia Bi, Khamal Kwesi Ampah, Chunmei Zhang, Ziyi Li,et al (2013) Lipid raft regulates the initial spreading of melanoma A375 cells bymodulating 1 integrin clustering. The International Journal of Biochemistry & Cell Biology. 45 1679– 1689
21278
a-Synuclein(Ab-136) Antibody
Shan-chuan Zhong • Xue Luo • Xing-shu Chen •Qi-yan Cai • Jing Liu • Xing-hua Chen •Zhong-xiang Yao,Expression and Subcellular Location of Alpha-Synuclein During Mouse-Embryonic Development,Cell Mol Neurobiol (2010) 30:469–482
21279
CaMKII (Ab-286) Antibody
J Bossuyt, K Helmstadter, X Wu, et al. (2008)Ca2+/Calmodulin-Dependent Protein Kinase II {delta} and Protein Kinase D Overexpression Reinforce. Circulation Research, 102(6):695-702.
21285
MARCKS(Ab-158) Antibody
Maria C. Olianas, Simona Dedoni, Pierluigi Onali (2011) Signaling pathways mediating phosphorylation and inactivation of glycogen synthase kinase-3b by the recombinant human d-opioid receptor stably expressed in Chinese hamster ovary cells. Neuropharmacology. 60:1326-1336
21286
MEK1 (Ab-291) Antibody
Hanqian Xu, Gan Zhao, Xiaoxi Huang,et al (2010)CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. The Journal of Gene Medicine.12(1).97-106
21300
CREB(Ab-142) Antibody
Tomasz Boczek • Anna Kozaczuk • Bozena Ferenc •Michalina Kosiorek • Slawomir Pikula •Ludmila Zylinska, Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin, Mol Cell Biochem (2012) 360:89–102
21302
IGF-1R(Ab-1280) Antibody
Hossein Haghir, Abd-Al-Rahim Rezaee, Hossein Nomani, Mojtaba Sankian, et al.(2013) Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol. 33:369–377
21303
IGF-1R(Ab-1346) Antibody
Hossein Haghir, Abd-Al-Rahim Rezaee, Hossein Nomani, Mojtaba Sankian, et al.(2013) Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. Cell Mol Neurobiol. 33:369–377
21310
GSK3b(Ab-216) Antibody
Ye Feng, Yiyuan Xia, Guang Yu, Xijing Shu, et al. (2013) Cleavage of GSK-3b by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3b activity induced by H2O2. J. Neurochem. 126, 234--242
21319
SHP-2(Ab-542) Antibody
Xiangyang Yao, Fenfen Zhu, Zhihui Zhao, Chang Liu, et al. (2011) Arctigenin Enhances Chemosensitivity of Cancer Cells to Cisplatin Through Inhibition of the STAT3 Signaling Pathway. Journal of Cellular Biochemistry 112:2837–2849
21325
Smad3(Ab-425) Antibody
Mitsuko Moriguchi, Marie Yamada, Yasuo Miake and Mayu Koshika. (2012) Immunolocalization of Axin2 and p-Smad3 in Developing Rat Molar Germ.Journal of Hard Tissue Biology. 21[2] p.113 - 120
21328
TrkB(Ab-705) Antibody
Ning LI, Geng-tao LIU. (2010) The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta Pharmacologica Sinica. 31: 265–272
21390
Myc Mouse Monoclnal Antibody
Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.
21390
Myc Mouse Monoclnal Antibody
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.
21401
Niban Antibody
Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.
21405
STAT3(Ab-705) Antibody
Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, et al.(2013) Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K–Akt signaling pathways. Regulatory Peptides. 181:9–16
21420
Caspase3 Antibody
Shen J, et al., The use of hollow mesoporous silica nanospheres to encapsulate bortezomib and improve efficacy for non-small cell lung cancer therapy, Biomaterials (2013) Volume 35, Issue 1, January 2014, Pages 316–326
21488
Vimentin Antibody
Chuanxi Tian, Yifan Gong, Ying Yang, Wei Shen, et al.(2012) Foxg1 Has an Essential Role in Postnatal Development of the Dentate Gyrus. The Journal of Neuroscience, 32(9):2931–2949
21507
coflin1/cofilin2(Ab-88) Antibody
Xiaodong Li, Qiang Ke, Yanshu Li, Funan Liu, Ge Zhu, Feng Li ,DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1 ,The International Journal of Biochemistry& Cell Biology 42 (2010) 70–79 Contents lists
21508
PI3K P85 a/g/b(Ab-467/199/464) Antibody
Nan Li, Xiaodong Bu, Peng Wu, Pingping Wu, Peilin Huang (2012) The ‘‘HER2–PI3K/Akt–FASN Axis’’ Regulated Malignant Phenotype of Colorectal Cancer Cells. Lipids 47:403–411
21508
PI3K P85 a/g/b(Ab-467/199/464) Antibody
Nan Li, Heng Lu, Chunyan Chen, Xiaodong Bu, et al. (2013) Loss of fatty acid synthase inhibits the “HER2-PI3K/Akt axis” activity and malignant phenotype of Caco-2 cells Lipids in Health and Disease. 12:83
21517
HDAC4/HDAC5/HDAC9(Ab-246/259/220) Antibody
Weiye Wang.(2010) A Novel Role of HDAC5 in Flow-Induced Gene Expression. Department of Pharmacology and Physiology School of Medicine and Dentistry University of Rochester Rochester
21538
Paxillin(Ab-88) Antibody
Ruifei Wang, Jiajia Bi, Khamal Kwesi Ampah, Chunmei Zhang, Ziyi Li,et al (2013) Lipid raft regulates the initial spreading of melanoma A375 cells bymodulating 1 integrin clustering. The International Journal of Biochemistry & Cell Biology. 45 1679– 1689
21545
FAK(Ab-576/577) Antibody
Jun-shan RUAN, Yu-ping LIU1, Lei ZHANG1, Ling-geng YAN, et al. (2012) Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the epithelial-mesenchymal transition. Acta Pharmacologica Sinica. 33: 1325–1331
21550
MDM2(Ab-166) Antibody
Hetian Lei, Gisela Velez, and Andrius Kazlauskas. (2010) Pathological Signaling via Platelet-Derived Growth Factor Receptor Involves Chronic Activation of Akt and Suppression of p53. MOLECULAR AND CELLULAR BIOLOGY, May 2011, p. 1788–1799
21574
b-catenin Antibody
RONG WAN, RUI GUO, CHENG CHEN, LAI JIN,et al(2012) Urocortin Increased LPS-Induced Endothelial Permeability by Regulating the Cadherin–Catenin Complex via
Corticotrophin-Releasing Hormone Receptor 2. JOURNAL OF CELLULAR PHYSIOLOGY. 228: 1295–130321574
b-catenin Antibody
Chih-Kai Liaoa, Seu-Mei Wanga, Yuh-Lien Chena, Hwai-Shi Wangb, Jiahn-Chun Wu, Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3, The International Journal of Biochemistry & Cell Biology 42 (2010) 762–770
21577
PKM1 Antibody
Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
(2014), http://dx.doi.org/10.1016/j.molcel.2013.11.00121577
PKM1 Antibody
Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.
21578
PKM2 Antibody
Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
(2014), http://dx.doi.org/10.1016/j.molcel.2013.11.00121578
PKM2 Antibody
Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150(4):685-696, 8/2012.
21578
PKM2 Antibody
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 14(12):1295-304, 2012. PMID: 23178880.
21689
Histone H3 (Ab-27) Antibody
MIN HUANG, JING ZHOU, LIQING BI, QIAN ZHANG, SUMING ZHOU (2012) Anti-Toll-like receptor 2 antibody, T2.1, reduces tumor necrosis factor α and interleukin-6 release and inhibits nuclear factor κB expression in bacterial lipoprotein stimulated THP-1 cells.Centr Eur J Immunol. 37 (1): 6-10
21689
Histone H3 (Ab-27) Antibody
Lian-Qing Sun, Jue Zha, Ting–Ting Zhang, Ling Qu, et al. (2012) Protective Effects of Salvianolic Acid B on Schwann Cells Apoptosis Induced by High Glucose. Neurochem Res 37:996–1010
21689
Histone H3 (Ab-27) Antibody
Lian-Qing Sun, Bing Xue, Xiao-Jin Li, Xuan Wang, Ling Qu, Ting-Ting Zhang, Jue Zhao, Bao-An Wang, Xiao-Man Zou, Yi-Ming Mu, Ju-Ming Lu,Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose,Life Sciences 90 (2012) 99–108
22267
ZNF346 antibody
Yan Chen, Shen Yue, Lu Xie, Xiao-hong Pu,Tian Jin and Steven Y. Cheng, Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3 b Regulates Its Stability and Localization in the Primary Cilium, THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 15, pp. 13502–13511, April 15, 2011
22966
ADP-ribosylation factor 3 antibody
Jian-ye Zhang, Tao Yi, Jing Liu, Zhong-zhen Zhao, et al. (2013) Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells. Journal of Agricultural and Food Chemistry. 61:2188−2195
23220
STAT3 Antibody
Xiang Cheng, Jing Wang, Ni Xia, Xin-Xin Yan, et al. (2012) A guanidine-rich regulatory oligodeoxy-nucleotideimproves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 4:1112–1125
23630
EGFR Antibody
Frédéric Couture, François D’Anjou,Roxane Desjardins, François Boudreau and Robert Day, Role of Proprotein Convertases in Prostate Cancer Progression, Neoplasia (2012) 14, 1032–1042
24050
Caspase-9 Antibody
Jian-ye Zhang, Tao Yi, Jing Liu, Zhong-zhen Zhao, et al. (2013) Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells. Journal of Agricultural and Food Chemistry. 61:2188−2195
24250
Bax Antibody
Wei-Jun Pang,Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-she Yang (2013) Lentivirus-mediated Sirt1 shRNA and resveratrol independently
induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Mol Biol Rep. 40:129–13924313
4E-BP1 Antibody
Manujendra N. Saha1,2, Hua Jiang3, Yijun Yang1,2, Xiaoyun Zhu1,2, Xiaoming Wang4, Aaron D.Schimmer4, Lugui Qiu5, Hong Chang,Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma, January 2012 | Volume 7 | Issue 1 | e30215
24317
anti-Irs1
Daisuke Ekuni, Takaaki Tomofuji, Koichiro Irie, Kenta Kasuyama, Michihiro Umakoshi, Tetsuji Azuma,Naofumi Tamaki, Toshihiro Sanbe, Yasumasa Endo, Tatsuo Yamamoto, Takashi Nishida and Manabu Morita,Effects of periodontitis on aortic insulin resistance in an obese rat model,Laboratory Investigation (2010) 90, 348–359
24458
PKR Antibody
Suzette Laing,1* Guohui Wang,1* Tamara Briazova,1 Chunbin Zhang,1 Aixia Wang,5 Ze Zheng,1Alexander Gow,1,3,4 Alex F. Chen,8 Sanjay Rajagopalan,5 Lung Chi Chen,7 Qinghua Sun,5,6§ and Kezhong Zhang1,2,Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues, Am J Physiol Cell Physiol 299: C736–C749, 2010.
24534
Bub3 Antibody
Jiang et al., PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells, Molecular Cell
(2014), http://dx.doi.org/10.1016/j.molcel.2013.11.00125541
β-catenin Antibody
Lei Hana, Yang Yanga, Xiao Yuea, Kai Huanga, et al. (2010) Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription. BRAIN RESEARCH 1366:9–17
29022
TNF alpha antibody
Desong Kong, Feng Zhang, Donghua Wei, Xiaojing Zhu, et al.(2013) Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-kB pathway in activated stellate cells: In vivo and in vitro studies. Journal of Gastroenterology and Hepatology. 28:1223–1233
29101
Caspase 3 Antibody
Jian-ye Zhang, Tao Yi, Jing Liu, Zhong-zhen Zhao, et al. (2013) Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells. Journal of Agricultural and Food Chemistry. 61:2188−2195
29139
MAVS Antibody
Wang B, Xi X, Lei X, Zhang X, Cui S, et al. (2013) Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses. PLoS Pathog 9(3): e1003231. doi:10.1371/journal.ppat.1003231
29162
ERK1/2
Yinbo Niu, Yuhua Li, Haitao Huang, Xianghe Kong, et al. (2011) Asperosaponin VI, A Saponin Component from Dipsacus asper Wall, induces Osteoblast Differentiation through Bone Morphogenetic Protein‐2/p38 and Extracellular Signal‐regulated Kinase 1/2 Pathway. Phytother. Res. 25: 1700–1706
29162
ERK1/2 Antibody
Zhifeng Wei,1 Jian Yang,1 Yu-Feng Xia,1 Wen-Zhe Huang,2 Zheng-Tao Wang,2 and Yue Dai, Cardamonin Protects Septic Mice from Acute Lung Injury by Preventing Endothelial Barrier Dysfunction, J BIOCHEM MOLECULAR TOXICOLOGY,Volume 26, Number 7, 2012
29227
PLC gamma 1 Antibody
Cheng-Ying Hsieh, Chien-Liang Liu, Ming-Jen Hsu, Thanasekaran Jayakumar, et al. (2010) Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation. Free Radical Biology & Medicine. 49:881–893
51041
NF-kB p65(Phospho-Ser536) antibody blocking peptide
KEFENG WU, YI LIU1, YINGNIAN LV, LIAO CUI, et al. (2013) Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid induces apoptosis and cell cycle arrest in CNE-2Z nasopharyngeal carcinoma cells. ONCOLOGY REPORTS. 29: 2101-2108
51080
EGFR(Phospho-Ser1070) antibody blocking peptide
Frédéric Couture, François D’Anjou,Roxane Desjardins, François Boudreau and Robert Day, Role of Proprotein Convertases in Prostate Cancer Progression, Neoplasia (2012) 14, 1032–1042
51111
Tau(Phospho-Ser262) antibody blocking peptide
J. BERTRAND, V. PLOUFFE, P. SÉNÉCHAL AND N. LECLERC, THE PATTERN OF HUMAN TAU PHOSPHORYLATION IS THE RESULT OF PRIMING AND FEEDBACK EVENTS IN PRIMARY HIPPOCAMPAL NEURONS, Neuroscience 168 (2010) 323–334
51136
FKHR(Phospho-Ser319) antibody blocking peptide
Tomoko Kanao, Katerina Venderova, David S. Park, Terry Unterman, et al.(2010) Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Human Molecular Genetics, Vol. 19, No. 19 3747–3758
51136
FKHR(Phospho-Ser319) antibody blocking peptide
Kanao T, Sawada T, Davies S-A, Ichinose H, Hasegawa K, et al. (2012) The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila. PLoS ONE 7(2): e30958. doi:10.1371/journal.pone.0030958
51174
AMPK1/AMPK2(Phospho-Ser485/Ser491) antibody blocking peptide
Sheng-Yang Jiang, Ming Xu, Xiao-Wei Ma, Han Xiao, et al.(2010) A distinct AMP-activated protein kinase phosphorylation site characterizes cardiac hypertrophy induced by L-thyroxine and angiotensin II. Clinical and Experimental Pharmacology and Physiology. 37:919–925
51193
HDAC5(Phospho-Ser498) antibody blocking peptide
Sheng Xia, Xiaogang Li, Teri Johnson, Chris Seidel, Darren P. Wallace, and Rong Li (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. Volume 137, Pages 1075-1084
51221
mTOR(Phospho-Ser2448) antibody blocking peptide
MM Sun, MZ Zhang, Y Chen, SL Li, W Zhang, GW Ya and KS Chen,Mechanistic Target of pamycin Small Interfering RNA and Rapamycin Synergistically Inhibit Tumour Growth in a Mouse enograft Model of Human Oesophageal Carcinoma,The Journal of International Medical Research 2012; 40: 1636 – 1643
11174
anti-phospho-AMPKα1 (phospho-Ser487)
Yan-Na Huang, Jian-Hua Qi, Lan Xiang , Yi-Zhen Wang(2012)Construction of adiponectin-encoding plasmid DNA and overexpression in mice in vivo.Gene 502 (2012) 87–93
I4001
Rabbit IgG
Jing Qian, Chunyan Zhang, Xiaodong Cao, et al (2010) Versatile Immunosensor Using a Quantum Dot Coated Silica Nanosphere as a Label for Signal Amplification. Anaytical Chemistry,82 (15), 6422–6429
I4001
Rabbit IgG
Hongyan Shi, Liang Yuan, Yafeng Wu, Songqin Liu (2011) Colorimetric immunosensing via protein functionalized gold nanoparticle probe combined with atom transfer radical polymerization. Biosensors and Bioelectronics, Volume 26, Issue 9, Pages 3788-3793
I4001
Rabbit IgG
Jing Qian, Haichao Dai, Xiaohu Pan, Songqin Liu, et al (2011) Simultaneous detection of dual proteins using quantum dots coated silica nanoparticles as labels. Biosensors and Bioelectronics, Volume 28, Issue 1, Pages 314-319
L3011
Goat anti-Rabbit IgG Secondary antibody unconjugated
Hongyan Shi, Liang Yuan, Yafeng Wu, Songqin Liu (2011) Colorimetric immunosensing via protein functionalized gold nanoparticle probe combined with atom transfer radical polymerization. Biosensors and Bioelectronics, Volume 26, Issue 9, Pages 3788-3793
L3011
Goat anti-Rabbit IgG Secondary antibody unconjugated
Jing Qian, Haichao Dai, Xiaohu Pan, Songqin Liu, et al (2011) Simultaneous detection of dual proteins using quantum dots coated silica nanoparticles as labels. Biosensors and Bioelectronics, Volume 28, Issue 1, Pages 314-319
L3011
Goat anti-Rabbit IgG Secondary Antibody Unconjugated
Jing Qian, Chunyan Zhang, Xiaodong Cao, and Songqin Liu. (2010) Versatile Immunosensor Using a Quantum Dot Coated Silica Nanosphere as a Label for Signal Amplification. Anal. Chem. 82:6422–6429
L3011
Goat anti-Rabbit IgG Secondary Antibody Unconjugated
Liang Yuan, Yafeng Wu, Hongyan Shi, and Songqin Liu. (2011) Surface-Initiated Atom-Transfer Radical Polymerization of 4-AcetoxyACHTUNGTRENUNGstyrene for Immunosensing. Chem. Eur. J. 17:976–983
L3012
Goat anti-Rabbit IgG Secondary antibody HRP conjugated
Hanqian Xu, Gan Zhao, Xiaoxi Huang,et al (2010)CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. The Journal of Gene Medicine.12(1).97-106
L3012
Goat anti-Rabbit IgG Secondary antibody HRP conjugated
Jing Qian, Chunyan Zhang, Xiaodong Cao, et al (2010) Versatile Immunosensor Using a Quantum Dot Coated Silica Nanosphere as a Label for Signal Amplification. Anaytical Chemistry,82 (15), 6422–6429
L3012
Goat anti-Rabbit IgG Secondary Antibody HRP conjugated
Yonggen Jia, Xinxin Zhao, Jingru Zou, Xun Suo. (2011) Trypanosoma evansi: Identification and characterization of a variant surface glycoprotein lacking cysteine residues in its C-terminal domain. Experimental Parasitology 127:100–106
L3012
Goat anti-Rabbit IgG Secondary Antibody HRP conjugated
Yudong Liu, Ying Su, Shenggang Sun, Tao Wang, et al. (2012) Tau Phosphorylation and m-Calpain Activation Mediate the Dexamethasone-Induced Inhibition on the Insulin-Stimulated Akt Phosphorylation. PLoS ONE 7(4): e35783. doi:10.1371/journal.pone.0035783
L3012
Goat anti-Rabbit IgG Secondary Antibody HRP conjugated
YONG CHENG, LI-YOU AN, YU-GUO YUAN, YI WANG, et al. (2012) Hybrid Expression Cassettes Consisting of a Milk Protein Promoter and a Cytomegalovirus Enhancer Significantly Increase Mammary-Specific Expression of Human Lactoferrin in Transgenic Mice. Molecular Reproduction & Development 79:573–585
L3012
Goat anti-Rabbit IgG Secondary Antibody HRP conjugated
Saito S, Yamamoto H, Mukaisho K-i, Sato S, Higo T, et al. (2013) Mechanisms Underlying Cancer Progression Caused by Ezrin Overexpression in Tongue Squamous Cell Carcinoma. PLoS ONE 8(1): e54881. doi:10.1371/journal.pone.0054881
L3012
Goat anti-Rabbit IgG Secondary Antibody HRP conjugated
Ing-Chien Chen,za Chung-Ming Yu,za Yu-Ching Lee,a Yi-Jen Huang,ab Hung-Ju Hsuac and An-Suei Yang, Signal sequence as a determinant in expressing disulfide-stabilized single chain antibody variable fragments (sc-dsFv) against human VEGF,Mol. BioSyst., 2010, 6, 1307–1315 | 1307
L3032
Goat anti-Mouse IgG Secondary Antibody HRP conjugated
Lei Wu, Ya-nan Jiang, Qian Tang, Hui-xing Lin, et al. (2012) Development of an Aeromonas hydrophila recombinant extracellular protease vaccine. Microbial Pathogenesis. 53:183-188
L3032
Goat anti-Mouse IgG Secondary Antibody HRP conjugated
Jossimara Polettini a,*, Eliane Passarelli Vieira a, Mariana Perlati dos Santos a, Jose´ Carlos Perac¸oli b,Steven S. Witkin c, Ma´ rcia Guimara˜es da Silva, Interleukin 18 messenger RNA and proIL-18 protein expression in chorioamniotic membranes from pregnant women with preterm prelabor rupture of membranes, European Journal of Obstetrics & Gynecology andReproductive Biology 161 (2012) 134–139
L3041
Rabbit anti-Goat IgG Secondary antibody unconjugated
Jing Qian, Chengquan Wang, Xiaohu Pan, Songqin Liu (2013) A high-throughput homogeneous immunoassay based on Förster resonance energy transfer between quantum dots and gold nanoparticles. Analytica Chimica Acta. 763:43– 49
L3042
Rabbit anti-Goat IgG HRP conjugated
Hongyan Shi, Liang Yuan, Yafeng Wu, Songqin Liu, Colorimetric immunosensing via protein functionalized gold nanoparticle probe combined with atom transfer radical polymerization, Biosensors and Bioelectronics 26 (2011) 3788–3793
L3042
Rabbit anti-Goat IgG HRP conjugated
Gyula Acsadi & Xingli Li & Kelley J. Murphy &Kathryn J. Swoboda & Graham C. Parker, Alpha-Synuclein Loss in Spinal Muscular Atrophy, J Mol Neurosci (2011) 43:275–283
L3051
Rabbit anti-Humant IgG Secondary antibody unconjugated
Jing Qian, Chengquan Wang, Xiaohu Pan, Songqin Liu (2013) A high-throughput homogeneous immunoassay based on Förster resonance energy transfer between quantum dots and gold nanoparticles. Analytica Chimica Acta. 763:43– 49
L3052
Rabbit anti-Human IgG secondary antibody HRP-conjugated
Loris Riccardo Lopetusoa, Valentina Petitoa, Valerio Cufinob, Vincenzo Arenab, Egidio Stigliano b, Viviana Gerardia, Eleonora Gaetania, Andrea Posciad, Arianna Amatoc, Giovanni Cammarotaa, Alfredo Papaa, Alessandro Sgambatob, Antonio Gasbarrinia, Franco Scaldaferri ,Locally injected Infliximab ameliorates murine DSS colitis: Differences in serum and intestinal levels of drug between healthy and colitic mice, L.R. Lopetuso et al. / Digestive and Liver Disease xxx (2013) xxx– xxx
T501
HA-Tag Rabbit Polyclonal Antibody
Yuan Qiu, Yan Ding, Lingyun Zou, Zhangping Tan, et al (2013) Divergent Roles of Amino Acid Residues Inside and Outside the BB Loop Affect Human Toll-Like Receptor (TLR)2/2, TLR2/1 and TLR2/6 Responsiveness. PLoS ONE 8(4): e61508. doi:10.1371/journal.pone.0061508
T501
HA-Tag Rabbit Polyclonal Antibody
Sai Srinivas Panapakkam Giridharan, Bishuang Cai, Nicolas Vitale, Naava Naslavsky, et al. (2013) Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. Molecular Biology of the Cell. Volume 24:1776-1790
T501
HA-Tag Rabbit Polyclonal Antibody
Haitao Ji, Zhiyong Ding, DavidHawke, Dongming Xing, et al. (2012) AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EUROPEAN MOLECULAR BIOLOGY ORGANIZATION. VOL 13 NO 6:554-560
T501
HA-Tag Rabbit Polyclonal Antibody
Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.
T502
HA-Tag Mouse Monoclonal Antibody
Ji H, Ding Z, Hawake D, Jiang B, Mills G, Lu Z. AKT-dependent Phosphorylation of Niban Regulates Nucleophosmin- and MDM2-Mediated p53 Stability and Cell Apoptosis. EMBO Reports 13(6):554-60, 6/2012. PMID: 22510990.
T503
polyclonal DYKDDDDK tag
Juliette Gafni, Xin Cong, Sylvia F. Chen, et al.(2009) Calpain-1 Cleaves and Activates Caspase-7J. Biol. Chem., 284: 25441 - 25449.
T503
DYKDDDDK-Tag Rabbit Polyclonal Antibody
Wang Jian, Zou Ning, Pan Xuwen, Liu Sidang.Establishment of a Cell Line with Stable Expression of HLA-A33 Protein[J].Biotechnology Bulletin, (2011) 11:212-215
T507
GFP-Tag mouse mAb
Qianqian Li, Hongbin Zhang, Cui Tan, Weiyan Peng, et al. (2013) AdHu5-apoptin induces G2/M arrest and apoptosis in p53-mutated human gastric cancer SGC-7901 cells. Tumor Biol.DOI 10.1007/s13277-013-0936-3
-
Partner Resources
-
Cancer Related Pathway
Akt PathwayApoptosis PathwayCell Cycle RegulationChannel PathwayChromatin/Transcription RegulationCytoskeleton/AdhesionDNA Damage/RepairImmune System RegulationInsulin/Glucose MetabolismJak/Stat PathwayKinases/PhosphatasesMAPK PathwayNF-kappa B PathwayRTKs/AdaptorsStem Cell RegulationTGFb/smads PathwayTranslation RegulationWnt/Notch/Hedgehog Pathway -
New catalogue for 2013 of SAB
-
Oncoproteins/Suppressors
An oncogene is a gene that has the potential to cause cancer.[ In tumor cells, they are often mutated or expressed at high levels. Most normal cells undergo a programmed form of death (apoptosis). Activated oncogenes can cause those cells that ought to die to survive and proliferate instead. Most oncogenes require an additional step, such as mutations in another gene, or environmental factors, such as viral infection, to cause cancer. Since the 1970s, dozens of oncogenes have been identified in human cancer. Many cancer drugs target the proteins encoded by oncogenes.A proto-oncogene is a normal gene that can become an oncogene due to mutations or increased expression. The resultant protein may be termed an oncoprotein. Proto-oncogenes code for proteins that help to regulate cell growth and differentiation. Proto-oncogenes are often involved in signal transduction and execution of mitogenic signals, usually through their protein products.Suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. Tumor-suppressor genes either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both.Selected Reviews:Croce CM (2008) Oncogenes and cancer. N Engl J Med. 358 (5): 502-11Yokota J (2000) Tumor progression and metastasis. Carcinogenesis. 21 (3): 497-503May P (1999) Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene. 18(53):7621-36Melamud A (2006) Retinoblastoma. Am Fam Physician 73 (6): 1039-44 -
Cell Cycle
Cell cycle, or cell-division cycle, is the series of events that take place in a cell leading to its division and duplication (replication). Cell cycle control affects many aspects of development. Caenorhabditis elegans cell-cycle genes have been identified over the past decade, including at least two distinct Cyclin-Dependent Kinases (CDKs), their cyclin partners, positive and negative regulators, and downstream targets. The balance between CDK activation and inactivation determines whether cells proceed through G1 into S phase, and from G2 to M, through regulatory mechanisms that are conserved in more complex eukaryotes. Many different stimuli exert checkpoint control including TGF, DNA damage, contact inhibition, replicative senescence, and growth factor withdrawal. G1 phase CDKs and their inhibitors (CKIs) are central to the pathways that regulate commitment to cellular division in response to positive as well as negative growth effectors. Many checkpoints are deregulated in oncogenesis, and this is often due to alterations in cyclin-CDK complexes.CDK activity is modulated by cyclin binding, phosphorylation, and CKIs, including the INK4 proteins and the closely related inhibitors p21Cip1 and p27Kip1. The downstream targets of CDKs and their modulation by TGF-beta and other growth factors include proteins of the retinoblastoma family, and the related modulation of the transcriptional activity of the E2F family members.A disregulation of the cell cycle components may lead to tumor formation. As mentioned above, some genes like the cell cycle inhibitors, RB, p53 etc., when they mutate, may cause the cell to multiply uncontrollably, forming a tumor. The cells which are actively undergoing cell cycle are targeted in cancer therapy.
Selected Reviews:Dyson, N. (1998) The regulation of E2F by pRB-family proteins. Genes Dev. 12, 2245-2262.Elledge SJ. (1996) Cell cycle checkpoints: preventing an identity crisis. Science. 274(5293):1664-72.Ravitz MJ, Wenner CE. (1997)Cyclin-dependent kinase regulation during G1 phase and cell cycle regulation by TGF-beta. Adv Cancer Res. 71:165-207.van den Heuvel S.(2005) Cell-cycle regulation. WormBook. 21:1-16. -
Cancer Stem Cell Markers
Cancer cells found within tumors or hematological cancers that possess characteristics associated with normal stem cells , specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are proposed to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for sufferers of metastatic disease .A number of studies have focused on identifying specific cancer stem cell markers. Pancreatic cancer stem cells express the surface markers CD44, CD24 and epithelial specific antigen (ESA). It has also been identified that liver progenitor cells share molecular markers with adult hepatocytes and fetal hepatocytes. In addition, markers frequently used to identify adult stem cells within the prostate, breast and intestine include CD44, CD133, ESA, CD69, p63, as well as some stem cell antigen, such as CD34, c-kit, Flt-3, NCAM, and Thy-1.Selected Reviews:Gupta PB (2009) Cancer stem cells: mirage or reality?. Nat Med 15 (9): 1010-2.Singh SK (2003) Identification of a cancer stem cell in human brain tumors. Cancer Research 63 (18): 5821-8Li C (2007) Identification of pancreatic cancer stem cells. Cancer Research 67 (3): 1030-7Dingli D. (2006) Successful therapy must eradicate cancer stem cells. Stem Cells 24, 2603-10. -
Cancer Biomarkers
Cancer biomarkers are substances indicate that tumor state, progression characteristics, and response to therapies. Most cancer biomarkers are transcription factors, cell surface receptors, or secreted proteins that are produced by either cancer cells or other cells in response to cancer. They are present in tumor tissues or body fluids. Cancer biomarkers can be used for screening the general population, for differential diagnosis in symptomatic patients, and for clinical staging of cancer. Additionally, cancer biomarkers can be used to estimate tumor volume, to evaluate response to treatment, to assess disease recurrence through monitoring, or as prognostic indicators of disease progression. During the last decade, improved understanding of carcinogenesis and tumor progression has revealed a large number of potential cancer markers. It is predicted that even more will be discovered in the near future with the application of the new emerging genomics and proteomics technologies.
Selected Reviews:
Ludwig JA( 2005) Biomarkers in cancer staging, prognosis and treatment selection. Nat. Rev. Cancer 5 (11): 845-56.
Kulasingam V, et al. (2007) Tissue culture-based breast cancer biomarker discovery platform. Int J Cancer. 123(9):2007-12.
Singer E. A.(2007) PSA Screening and Elderly Men. JAMA 297 (9): 949
Jacobs Jon M.(2005) Utilizing Human Blood Plasma for Proteomic Biomarker Discovery. Journal of Proteome Research 4 (4): 1073-85 -
Apoptosis
Apoptosis is a naturally occurring process by which a cell is directed to Programmed Cell Death. Apoptosis is based on a genetic program that is an indispensable part of the development and function of an organism and is a regulated physiological process leading to cell death.In apoptosis pathways, signaling results in the activation of a family of Cysteine Proteases, named Caspases that act in a proteolytic cascade to dismantle and remove the dying cell, are central regulators of apoptosis. Initiator caspases (including 8, 9, 10) are closely coupled to pro-apototic signals. Once activated, these caspases cleave and activate downstream effector caspases (3, 6, 7) which in turn cleave cytoskeletal and nuclear proteins and induce apoptosis. Cytochrome C released from damaged mitochondria is coupled to the activation of caspase 9.Pro-apoptotic stimuli include the FasL, TNF, DNA damage. Fas and TNFR activate caspases 8 and 10; DNA damage leads to the activation of caspase 9. Anti-apoptotic ligands including growth factors and cytokines activate AKT and p90RSK, which inhibit Bad and prevent cytochrome C release. TNFR can also stimulate an anti-apoptotic pathway by inducing IAP, which directly inhibits caspases 3, 7 and 9.Alternatively, apoptosis is inhibited via an adaptor protein complex which activates NF-kB and induces survival genes including IAP. The Bcl-2 family of proteins regulate apoptosis by controlling mitochondrial permeability and the release of cytochrome C. The anti-apoptotic proteins Bcl-2 and Bcl-xL reside in the outer mitochondrial wall and inhibit cytochrome C release. The pro- apoptotic Bcl-2 proteins Bad, Bid, Bax and Bim reside in the cytosol but translocate to mitochondria following death signaling, where they promote the release of cytochrome C. Bad translocates to mitochondria and forms a pro-apoptotic complex with Bcl-xL. This translocation is inhibited by survival factors that induce the phosphorylation of Bad, leading to its cytosolic sequestration. Bax and Bim translocate to mitochondria in response to death stimuli, including survival factor withdrawal. Bcl-xL, Bcl-2 and Bax apparently influence the voltage-dependent anion channel (VDAC), which can control cytochrome C release. p53, activated following DNA damage, induces the transcription of Bax. Released cytochrome C binds Apaf1 and forms an activation complex with caspase9.Selected Reviews:Alberts Bruce (2008) Chapter 18 Apoptosis: Programmed Cell Death Eliminates Unwanted Cells. Molecular Biology of the Cell (textbook) (5th ed.). Garland Science. p. 1115. ISBN 978-0-8153-4105-5.Czerski L. (2004) Apoptosome formation and Caspase activation:is it different in the heart. J Mol Cardiol.37(13),643-652.Debatin K.M.(2004) Death receptors in chemotherapy and cancer. Oncogene 23(16), 2950-66.Lamkanfi M. (2007) Caspases in cell survival, proliferation and differentiation. Cell Death and Differentiation 14 (1): 44-55. -
Angiogenesis
Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, and is a normal and vital process in growth and development, as well as in wound healing and in granulation tissue. Angiogenesis is regulated by multiple factors, including growth and differentiative factors, extracellular matrix components, membrane-bound receptors, intracellular signaling molecules, and angiogenesis inhibitors. Several growth factors, including FGFs (fibroblast growth factors), VEGFs (vascular endothelial growth factors), PDGFs, eprins, angiopoietins, TGF-beta and other participate in regulating angiogenesis. Angiogenesis inhibitors can be endogenous or exogenous. Endogenous angiogenesis inhibitors may be interleukins, interferons, chemokines, or growth factor regulators.In health, the body maintains a balance of angiogenesis regulators. However, the structures formed are often functionally abnormal, possibly due to an imbalance in the angiogenic process. Imbalance of angiogenesis stimulation and inhibition can lead to disease. In cancer, like tissues of the body, tumors need a blood supply. They get this through new blood vessel formation (angiogenesis). This is a fundamental step in the transition of tumors from a dormant state to a malignant one.Selected Reviews:Risau W. (1995) Vasculogenesis. Annual review of cell and developmental biology. 11: 73-91.Carmeliet P. (2005) Angiogenesis in life, disease and medicine. Nature. 438(7070):932-6.Tan A. (2010) Angiogenesis-inhibitors for metastatic thyroid cancer. Cochrane Database Syst Rev.3:CD007958.Flamme I. (1997) Molecular mechanisms of vasculogenesis and embryonic angiogenesis. Journal of cellular physiology 173 (2): 206-10. -
Adhesion Molecules
Adhesion Molecules are proteins located on the cell surface involved in binding with other cells or with the extracellular matrix (ECM) in the process of cell adhesion or cellular interactions. Essentially, adhesion molecules help cells stick to each other and to their surroundings. Adhesion Molecules include Integrins, Ig superfamily Cell Adhesion Molecules (CAMS), Cadherins, Lectins, and others. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton , a transmembrane domain, and an extracellular domain.Adhesion molecules play critical roles in a variety of biological processes. For instance, one important part adhesion molecules serve in the immune system is to enhance pairing between many less avid receptors and their ligands and transmit signals that direct specific effecter functions during an inflammatory response. In development they play key roles in tissue morphogenesis, cell migration, and axon guidance. Pathologically, adhesion molecules have been discovered to play a critical role in tumor cell invasiveness and metastases.Selected Reviews:Angst B. (2001)The cadherin superfamily: diversity in form and function. J Cell Sci. 114 (Pt 4): 629-41Zetter BR. (1993) Adhesion molecules in tumor metastasis. Semin Cancer Biol. 4(4):219-29.Hulpiau P. (2009)Molecular evolution of the cadherin superfamily. Int. J. Biochem. Cell Biol.. 41 (2): 349-69.Ikeda H. (1998) Cell adhesion molecule. Nippon Rinsho. 56(10):2493-9. -
Wnt/Notch/Hedgehog Pathway
Pathway description:During development, Wnt (Wingless-Type MMTV Integration Site Family) have diverse roles in governing cell fates, proliferation, migration, polarity, and death. In the absence of Wnt signaling, β-Catenin is associated with a cytoplasmic complex containing CK1, GSK3, Axin, APC and PP2A. This promotes phosphorylation of course β-Catenin and its interaction with β-TRCP, leading to the ubiquitination of β-Catenin and its degradation by the proteosome. In the presence of Wnt signaling, secreted Wnt glycoproteins bind to the receptor Frizzled, which leads to activation of the Dishevelled (Dsh) protein, a PDZ domain protein. Dsh acts to inhibit a cytoplasmic complex involving GSK3, Axin and APC that acts to degrade β-Catenin. GSK3 phosphorylates β-Catenin leading to ubiquitination and degradation by the proteosome. Activation of the Wnt/beta-catenin pathway inhibits degradation of β-Catenin allowing its nuclear transport and gene induction via bindng to TCF. During the elaboration of cell types and tissues, the Wnt/beta-catenin pathway often interacts with the FGF and TGF-β pathways. In adults, Wnt function in homeostasis, and inappropriate activation of the Wnt/beta-catenin pathway is implicated in a variety of cancer.Selected Reviews:Li F,Chong zz,et al.(2006)Winding through the WNT pathway during cellular development and demise.Histol Histopathol.21(1),103.Katoh M.(2005)Comparative genomics on Wnt5a and Wnt5b genes.Int J Mol Med.15(4),749.Li F,Chong zz,et al.(2005)Vital elements of the Wnt-Firizzled signaling pathway in the nervous system.Curr Neurovasc Res.2(4),331.Urano T.(2006)Wnt- beta-catenin signaling in bone metabolism.Clin Calcium. 16 (1),54. -
Translation Pathway
Pathway description:Translation initiation is a complex process in which initiator tRNA, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the initiation codon of mRNA. The cap-binding complex eIF4F and the factors eIF4A and eIF4B are required for binding of 43S complexes (comprising a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5′ end of capped mRNA but are not sufficient to promote ribosomal scanning to the initiation codon.The eukaryotic translation initiation factor 4F (eIF4F) mediates 40S ribosomal subunit binding to the 5'end of capped mRNA. eIF4F is a complex containing three proteins: eIF4E, the cap-binding subunit; eIF4A, an RNA-dependent ATPase/ATP-dependent RNA helicase; and eIF4G, a high-molecular-weight protein that acts as a scaffold for binding eIF4E and eIF4A. In addition, eIF4G interacts with the 40S ribosome binding factor eIF3 and the poly(A)-binding protein, thereby establishing a critical link between mRNA and the ribosome. The various eIF4F subunits are expressed to remarkably different levels in most cell types, with the eIF4E subunit being the least abundant.References:Anthony, D. D., and W. C. Merrick. (1991) Eukaryotic initiation factor (eIF)-4F. Implications for a role in internal initiation of translation. J. Biol. Chem. 266,10218-10226 Avdulov, S. et al. (2004) Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 5,553-563.Gingras, A. C.,et al. (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68,913-963.Hentze, M. W. (1997) eIF4G: a multipurpose ribosome adapter? Science 275,500-501Hershey, J. W. B., and W. C. Merrick.(2000) Translational control of gene expression Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. -
TGFb/smads Pathway

-
NF-kappa B Pathway
Pathway description:NF-Kappa B (Nuclear Factor-Kappa B) is a heterodimeric protein composed of different combinations of members of the Rel family of transcription factors. The Rel/ NF-Kappa B family of transcription factors are involved mainly in stress-induced, immune, and inflammatory responses. In addition, these molecules play important roles during the development of certain hemopoietic cells, keratinocytes, and lymphoid organ structures. NF-Kappa B is also an important regulator in cell fate decision, such as programmed cell death and proliferation controlled, and is critical in tumorigenesis. NF-Kappa B is composed of homo- and heterodimers of five members of the Rel family including NF-Kappa B1, NF-Kappa B2,RelA,RelB,and c-Rel. NF-Kappa B can be activated by exposure of cells to LPS or inflammatory cytokines such as TNF or IL-1,growth factors, lymphokines, oxidant-free radical, inhaled particles, viral infection or expression of certain viral or bacterial gene products, UV irradiation, B or T-cell activation, and by other physiological and non physiological stimulin.Selected Reviews:Baldwin AS Jr. (1996) The NF-Kappa B and I kappa B proteins:new discoveries and insights.Annu Rev Immunol.14,649.Vigo Heissmeyer and Daniel Krappmann,et al. (2001)Shared Pathways of I B Kinase-Induced SCF TrCP-Mediated Ubiquitination and Degradation for the NF-B Precursor precursor precursor p105 and I Bacterial. Molecular and Cellular Biology.21,1024.Joel L,Pomerantz and David Baltimore.(2002)Two pathway to NF-Kappa B.Molecular Cell.10,693. -
Kinases/Phosphatases Pathway
Pathway description:kinase, alternatively known as a phosphotransferase, is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific target molecules (substrates); the process is termed phosphorylation . The largest group of kinases are protein kinases, which act on and modify the activity of specific proteins. kinase are used extensively to transmit signals and control complex processes in cells. Up to 518 different kinases have been identified in humans. Their enormous diversity and role in signaling makes them attractive targets for drug design. Various other kinases act on small molecules (lipids, carbohydrates, amino acids, nucleotides, and more), either for signaling or to prime them for biochemical reactions in metabolism. These are named after their substrates.Deregulated kinase activity is a frequent cause of disease, particularly cancer, where kinases regulate many aspects that control cell growth, movement and death. Drugs which inhibit specific kinases are being developed to treat several diseases, and some are currently in clinical useA phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation). This action is directly opposite to that of phosphorylases and kinases, which attach phosphate groups to their substrates by using energetic molecules like ATP. The addition of a phosphate group may activate or de-activate an enzyme (e.g., Kinase signalling pathways ) or enable a protein-protein interaction to occur (e.g., SH3 domains); therefore phosphatases are integral to many signal transduction pathways.Therefore ,kinase and phosphatases are closely attached to each other in regulating various cellular events, and play an important role in signal transduction,References:Ladbury, JE. (2007)Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction, Acta Cryst D,62,pp26Zhong-Yin Zhang, (2002) PROTEIN TYROSINE PHOSPHATASES: Structure and Function, Substrate Specificity, and Inhibitor Development, Annual Review of Pharmacology and Toxicology 42, pp209Mumby, MC & Walter, (1993) G. Protein Serine/Threonine Phosphatases: Structure, Regulation, and Functions in Cell Growth Physiological Reviews,73,pp673 -
Insulin/Glucose Metabolism Pathway
Pathway description:Insulin has diverse effects on cells including stimulation of glucose transport, gene expression and alterations of cell morphology. Insulin signaling begins with either the activation or substrate kinase activity of the insulin receptor (IR), which is the only component of the pathway that is unique to insulin action. The insulin receptor belongs to a subfamily of receptor tyrosine kinases. Activation of the IR can be impaired by post-translational modifications of the protein involving serine phosphorylation, or by binding to inhibiting proteins such as PC-1 or members of the SOCS or Grb protein families. Insulin elicits a diverse array of biological responses by binding to its specific receptor. The hormone mediates these effects by activation of signaling pathways which adaptor molecules such the IRS, the SHC and the GRB2 lipid kinases such as PI3K serine, threonine and tyrosine.
Selected Reviews:ALAN R,SALTIEL,et al.(2001)Insulin signaling and the regulation of glucose and lipid metabolism.Nature.414(6865):799-806.Ogawa W,Matozaki T,et al.(1998)Role of binding proteins to IRS-1 in insulin signaling. Mol Cell Biochem.182(1-2):13-22.Youngren JF. (2007)Regulation of insulin receptor function. Cell Mol Life Sci. 64(7-8):873-91Johnston AM, Pirola L, Van Obberghen E.2003Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling. FEBS Lett. 546(1):32-6. -
DNA Damage/Repair Pathway

Pathway description:The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint- arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. The G2/M DNA damage checkpoint prevents the cell from entering mitosis (M phase) if the genome is damaged. Environmental DNA-damaging agents include UV light and ionizing radiation. Many of the checkpoint proteins are activated in response to DNA damaged, and a number of phosphorylation events in DNA repair mechanism depend on activation of these kinases. The Mec1/Rad3/ATM/ATR family act early in the checkpoint pathways either as DNA damage detectors or in close association with such detectors. The tumor suppressor P53 is central to the higher eukaryotic checkpoint controls in DNA damage-induced G1 arrest through transcriptional induction of the cyclin-dependent kinases Chk1 and Chk2, and inhibitor p21.Activation of p53 in response to DNA damage and other stresses involves complex posttranslational modification of p53 and its negative modulater MDM2,which is itself induced by p53 at the transcriptional level.Selected Reviews:Norbury CJ,Hickson ID.(2001)Cellular responses to DNA damage.Annu Rev Pharmacol Toxicol.41:367-461.Bartek J,Lukas J.(2003)Chk1 and Chk2 kinases in checkpoint control and cancer.Cancer Cell.3(5)421-9.Branzei D, Foiani M. (2008)Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol. 9(4):297-308. -
Cytoskeleton/Adhesion Pathway
Pathway description:G protein-coupled receptors (GPCRs), comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. GPCRs are activated by an external signal in the form of a ligand or other signal mediator. This creates a conformational change in the receptor, causing activation of a G protein.The extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly-conserved cysteine residues that form disulfide bonds to stabilize the receptor structure.The family of p21-activated protein kinases (PAKs) is composed of serine-threonine kinases whose activity is regulated by the small guanosine triphosphatases (GTPases), Rac and Cdc42 In mammalian cells, PAKs have been implicated in the regulation of mitogen-activated protein cascades, cellular morphological and cytoskeletal changes, neurite outgrowth, and cell apoptosis.Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in integrin-mediated control of cell behavior. Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at multiple sites, including tyrosines 397, 576, and 577. Tyr-397 is an autophosphorylation site that promotes interaction with c-Src or Fyn. Tyr-576 and Tyr-577 lie in the putative activation loop of the kinase domain, and FAK catalytic activity may be elevated through phosphorylation of these residues by associated Src family kinase. The clustering of integrins at these sites attracts a large complex of proteins and initiates intracellular regulatory processes, by which such events as cell migration and anchorage-dependent differentiation are controlled. FAK is a protein tyrosine kinase which is recruited at an early stage to focal adhesions and which mediates many of the downstream responses. FAK subsequently interacts with a number of down-stream signalling proteins, including the adaptor protein Grb2 and the p85 _-subunit of phosphatidylinositol 3 kinase (PI3 kinase)References:Daniels, R. H. & Bokoch, G. M. (1999) p21-Activated protein kinase: a crucial component of morphological signaling? Trends Biochem. Sci. 24, 350-355.Lei, M. et al. (2000) Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch . Cell 102, 387-397Joost P, Methner A(2002) Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biol 3 (11), research0063.1-0063.16.Bjarnadottir TK. et al. (2006) Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics 88 (3), 263-73.Astier A. et al. (1997) The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. J Biol Chem.272,228–232.Avraham S,.et al. (1995) Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem. 270,27742–27751. -
Chromatin/Transcription Pathway

Pathway description:Chromatin is the substance which becomes visible chromosomes during cell division. Its basic unit is nucleosome, composed of 146 bp DNA and eight histone proteins. The structure of chromatin is dynamically changing, at least in part, depending on the need of transcription. In the metaphase of cell division, the chromatin is condensed into the visible chromosome.Transcription is the process through which a DNA sequence is enzymatically copied by an RNA polymerase to produce a complementary RNA. In eukaryotes, it takes place in the nucleus, mitochondria and chloroplast.Protein acetylation plays a crucial role in regulating chromatin structure and transcriptional activity. Acetylation complexes or deacetylation complexes can be recruited to DNA-bound transcription factors (TFs) in response to signaling pathways. Histone hyperacetylation by histone acetyltransferases (HATs) is associated with transcriptional activation, presumably by remodeling nucleosomal structure into an open conformation more accessible to transcription complexes. Conversely, histone deacetylation by deacetylation complexes (such as HDAC) is associated with transcriptional repression reversing the chromatin remodeling process.Several transcriptional coactivators and corepressors possess intrinsic acetylase or deacetylase enzymatic activities, respectively. Site-specific acetylation of a growing list of non-histone proteins, including p53 and E2F, has been shown to play an important role in transcriptional regulation and cell proliferation.
Selected Reviews:
Davie JR, Samuel SK, Spencer VA, et al. (1999)Organization of chromatin in cancer cells: role of signalling pathways. Biochem Cell Biol.77(4):265-75.Spencer VA, Davie JR.(2000)Signal transduction pathways and chromatin structure in cancer cells. J Cell Biochem Suppl. 35:27-35.Crosio C, Heitz E, Allis CD,et al. (2003)Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J Cell Sci. 116(Pt 24):4905-14.






