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  • WBWestern Blotting
  • IHCImmunohistochemistry
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    Species Reactivity:
  • HuHuman
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  • Brief: The SABsHematopoietic Toxicity Compound Library is a focused collection of 104 compounds with defined and diverse hematopoietic toxicity, including myelosuppression, neutropenia, leukopenia, anemia, and many more. Bioactivity of all compounds were confirmed by bioassays, and reported by scientific literature. Some of them are FDA approved. The library is an essential tool for predictive toxicology screening and assay development.
  • Brief: Autophagyis the natural, regulated mechanism of the cell that disassembles unnecessary or dysfunctional components. Targeteddamaged cytoplasmicconstituents are isolated from the rest of the cell within a double-membraned vesicle known as anautophagosome.The autophagosome eventually fuses withlysosomesand the contents are degraded and recycled. Autophagy, cellular senescence, and apoptosis are three key responses of a cell facing a stress, correlating with each other. It has been reported that defects of autophagy are associated with genomic damage, metabolic stress, and tumorigenesis. The Autophagy Compound library by SAB contains 623 compounds with defined autophagy-inducing or -inhibitory activity, and is a useful tool for studying the roles of pro- and anti-autophagic molecules in cells as well as for use inin vitroapplications
  • Brief: Histamine, an important bioactive molecule, is derived from thedecarboxylationof theamino acidhistidine. Most histamine in the body is generated in granules inmast cellsand inskin, lung and gastrointestinal tract, playing a pivotal role in allergic and inflammatory reactions. Histamine acts as a neurotransmitter within the central nervous system. The histaminergic neurons that secrete histamine are localized in small regions of the hypothalamus, but those neurons send axons widely throughout the brain. Histamine appears to modulate a number of important processes in the brain, including wakefulness, cognitive ability andfood consumption. Currently four histamine receptors (H1R-H4R) have been cloned and identified, all of which are G protein-coupled receptors. These different receptors are expressed on different cell types and work through different intracellular signaling mechanisms. Post mortem studies have revealedalterations in histaminergic system in neurological and psychiatric diseases. Melatoninis ahormone, produced by thepineal gland, a tinyendocrinegland situated at the center of the brain. Melatonin presents several ways of action in the regulation of seasonal reproduction, body weight and energy balance, antiaging, and promoting sleep.
  • Brief: Clinical compound library is a collection of 960 compounds, all of which have been permitted into the clinical trial phases. These compounds have known biological activities, low toxicity, and clear mechanism with demonstrated pre-clinical evidence. Every compound contains detailed information on pharmacological activities, targets, clinical development status, and indications with broad spectrum covering several therapeutic areas from cancer, inflammation, infection, neuropsychiatry to cardiology, and many drug targets such as JAK, EGFR, mTOR, CDK, HDAC, AKT, PARP, etc. It is an effective tool for drug screening as well as for cell differentiation induction.
  • Brief: Preclinical Compound Library is a collection of 212 compounds that are in preclinical phase with clear targets and detailed information on disease indication and reference.
  • Brief: Ahistonemodificationis a covalent post-translational enzymatic modification to histone proteins which includesmethylation,phosphorylation,acetylation, ubiquitylation, and sumoylation.Histone modification impactsgene expressionbyaltering chromatin structureor recruiting histone modifiers.Therefore, histone modifications act in diverse biological processes such as transcriptional activation/inactivation,chromosomepackaging, and DNA damage/repair.Thus, quantitative detection of various histone modifications would provide useful information for a better understanding ofepigeneticregulation of cellular processes and the development of histone modifying enzyme-targeted drugs. The SABsHistone Modification Research Compound Library, a unique collection of 152 histone modification related compounds, can be used for research in histone modification and related drug screening
  • Brief: Cytokinesare a broad and loose category of smallproteins(~5�C20kDa) that are important incell signaling, modulate thebalancebetween humoral and cell-based immune responses, and are heavilyinvolved inautoimmuneand inflammatory diseases. Blocking cytokine signaling pathways by biologics has shown clinical effectiveness in these diseases. Cytokines act throughreceptors and activate related signaling to modulate gene expression and cell functions. Cytokine receptors activate many signaling pathways: JAK-STAT, NF-kB, MAPK, PI3K, etc. A number of small molecular weight inhibitors targeting cytokine signaling have been identified as research progresses and some are approved to be marketed. Cytokines Inhibitors Library from SAB, containing 182 compounds targeting cytokine signaling, can be used for high throughput and high content screening for drug discovery
  • Brief: Nuclear factor-��B (NF-��B), a collective term for a family of transcription factors, includes five subunits: NF-��B1 (p50/p105), NF-��B2 (p52/p100), p65 (RelA), RelB, and c-Rel. The homodimers or heterodimers formed by two subunits bind to specific sequences known as the ��B site on their target genes for DNA interaction and transcriptional activation. How NF-��B selectively recognizes a small subset of relevant ��B sites from the large excess of potential binding sites is a critical step for stimulus-specific gene transcription (The fine-tuning of the NF-B DNA binding activity).While in an inactivated state, NF-��B is located in the cytosol complexed with the inhibitory proteinI��B��. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzymeI��B kinase(IKK). IKK, in turn, phosphorylates the I��B�� protein, which results inubiquitination, dissociation of I��B�� from NF-��B, and eventual degradation of I��B�� by theproteasome. The activated NF-��B is then translocated into the nucleus where it binds to specific sequences of DNA called response elements (RE). The DNA/NF-��B complex then recruits other proteins such ascoactivatorsandRNA polymerase, which transcribe downstream DNA into mRNA. A large array of genesinvolved in different processes of the immune and inflammatory responses, such as TNF-��, IL-1��, IL-6, and IL-8, chemokines, adhesion molecules, clone stimulating factors, is mediated by NF-��B. In TNF-���Cinduced apoptosis, TRAF1, TRAF2, XIAP, c-IAP1, and c-IAP2 were identified as gene targets of NF-kB transcriptional activity. NF-��B Signaling Compound Library from SAB, a unique collection of 173 small molecules targeting NF-��B signaling, can be used for research in NF-��B signaling and high throughput screening and high content screening.
  • Brief: A significant barrier to effective cancer therapy is the development of resistance to the drugs utilized, therefore, identifying new biological targets and designing new drugs becomes one of the most important strategies. Among the various potential targets, DNA damage and repair system in cancer cells is one of the most pivotal targets. The use ofunspecific antibiotics to treat bacterial infections has caused a great deal of multiple resistant strains making less effective the current therapies with antibiotics. Developing inhibitors of DNA repair and related pathways in pathogens will have utility in the treatment of infections. The SABsDNA Damage & Repair Compound Library, a unique collection of 475 DNA Damage & Repair related compounds, can be used for research in DNA damage and repair, and high throughput screening (HTS) and high content screening (HCS).
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