• Product NameDNase II alpha Polyclonal Antibody Cy3 Conjugated
• Host SpeciesRabbit
• ClonalityPolyclonal
• IsotypeIgG
• PurificationPurified by Protein A.
• ApplicationsIF
• Species ReactivityHu Ms Rt
• Immunogen DescriptionKLH conjugated synthetic peptide aa 20-70 360 derived from human DNase II alpha
• ConjugatesCy3
• Excitation Emission512,550nm 570,615nm
• Target NameDNase II alpha
• Alternative Names    DNL; DNL2; DNASE2A; Deoxyribonuclease-2-alpha; Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2; DNASE2
• Accession No. Swiss-Prot#:O00115
  NCBI Gene ID:1777
• UniprotO00115
• Gene ID1777;
• Cell Localization Lysosome
• Concentration 1mg ml
• Formulation 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
• Storage Shipped at 4˚C. Store at -20˚C for one year. Avoid repeated freeze/thaw cycles.

• IF=1:50-200

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting