• Product NamePSEN1 antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntibodies were purified by affinity purification using immunogen.
• ApplicationsWB,IHC,IF
• Species ReactivityHuman,Mouse,Rat
• SpecificityThe antibody detects endogenous level of total PSEN1 protein.
• Immunogen TypeRecombinant Protein
• Immunogen DescriptionRecombinant protein of human PSEN1.
• Target NamePSEN1
• Alternative Names    PSEN1; AD3; FAD; PS-1; PS1; S182;
• Accession No. Swiss-Prot#: P49768
  NCBI Gene ID: 5663
• UniprotP49768
• Gene ID5663;
• SDS-PAGE MW 53kd
• Concentration 1.0mg/ml
• Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• WB 1:500 - 1:2000
  IHC 1:50 - 1:200
  IF 1:50 - 1:200

Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated γ-secretase activity for amyloid-β protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3).

• Western blot analysis of extracts of U-87MG cells, using PSEN1 at 1:1000 dilution.
• Immunohistochemistry of paraffin-embedded human breast cancer using PSEN1 at dilution of 1:100 (40x lens).
• Immunohistochemistry of paraffin-embedded human stomach using PSEN1 at dilution of 1:100 (40x lens).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting