protein_function: Growth factor active in angiogenesis and endothelialcell growth, stimulating their proliferation and migration. Itbinds to the receptor FLT1,VEGFR-1. Isoform PlGF-2 bindsNRP1,neuropilin-1 and NRP2,neuropilin-2 in a heparin-dependentmanner. Also promotes cell tumor growth..
The protein, also called PGF, is 149 amino acids long and shares 53% identity with the platelet-derived growth factor-like region of human VPF. And the N-glycosylated PLGF protein is secreted into the medium and that it functions as a dimer1. The PLGF gene is mapped to 14q24-q31. There are 3 isoforms of PGF, designated PGF1, PGF2, and PGF3. Only PGF2 is able to bind heparin. Additionally, PGF regulates inter- and intramolecular cross-talk between the VEGF receptor tyrosine kinases FLT1 and FLK12. It also can stimulate angiogenesis and collateral growth in ischemic heart and limb with at least a comparable efficiency to VEGF3.