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Human CD26,DPP4 ELISA Kit

EK5280
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EK5280 96T $599.00

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Description
  • Product Name Human CD26,DPP4 ELISA Kit
  • Specificity Human
  • Crossing Reactivity There is no detectable cross-reactivity with other relevant proteins.
  • Immunogen Type NSO,D34-P766
  • Alternative Names Dipeptidyl peptidase 4; 3.4.14.5; ADABP; Adenosine deaminase complexing protein 2; ADCP-2; Dipeptidyl peptidase IV; DPP IV; T-cell activation antigen CD26; TP103; CD26; Dipeptidyl peptidase 4 membrane form; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase 4 soluble form; Dipeptidyl peptidase IV soluble form; DPP4; ADCP2, CD26;
  • Accession No. P27487
  • Cell Localization Dipeptidyl peptidase 4 soluble form:Secreted. Detected in the serum and the seminal fluid.
Application Details

sensitivity:10pg ml
Detect Range:312pg ml-20 000pg ml
sample_type:cell culture supernates serum plasma(heparin EDTA) saliva and urine.
capture_antibody:monoclonal antibody from mouse
detection_antibody:polyclonal antibody from goat
gene_name:DPP4
protein_name:Dipeptidyl peptidase 4
gene_full_name:Dipeptidyl peptidase 4
tissue_specificity: Expressed specifically in lymphatic vesselsbut not in blood vessels in the skin small intestine esophagus ovary breast and prostate glands. Not detected in lymphaticvessels in the lung kidney uterus liver and stomach (at proteinlevel). Expressed in the poorly differentiated crypt cells of thesmall intestine as well as in the mature villous cells. Expressedat very low levels in the colon..
sequence_similarities:Belongs to the peptidase S9B family. DPPIV subfamily.
tmb_incubation:20-25min
research_category:kits/ lysates/ other|kits|cell metabolism kits|sugar assays

Product Description
Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human CD26,DPP4
Background
protein_function: Cell surface glycoprotein receptor involved in thecostimulatory signal essential for T-cell receptor (TCR)-mediatedT-cell activation. Acts as a positive regulator of T-cellcoactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Itsbinding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor,CD3-dependent manner. Itsinteraction with ADA also regulates lymphocyte-epithelial celladhesion. In association with FAP is involved in the pericellularproteolysis of the extracellular matrix (ECM), the migration andinvasion of endothelial cells into the ECM. May be involved in thepromotion of lymphatic endothelial cells adhesion, migration andtube formation. When overexpressed, enhanced cell proliferation, aprocess inhibited by GPC3. Acts also as a serine exopeptidase witha dipeptidyl peptidase activity that regulates variousphysiological processes by cleaving peptides in the circulation,including many chemokines, mitogenic growth factors, neuropeptidesand peptide hormones. Removes N-terminal dipeptides sequentiallyfrom polypeptides having unsubstituted N-termini provided that thepenultimate residue is proline..
Dipeptidyl peptidase-4(DPP4), also known as adenosine deaminase complexing protein 2 or CD26(cluster of differentiation 26) is a protein that, in humans, is encoded by the DPP4 gene. By fluorescence in situ hybridization, the CD26 gene was mapped to 2q24.3. DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. Furthermore, it appears to work as a suppressor in the development of cancer and tumours. CD26, DPP4 plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.
    Please let us know if you have published research using #EK5280 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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