protein_function: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis,intracellular cAMP accumulation, prostaglandin E2 secretion, andsynthesis of hyaluronic acid and sulfated glycosaminoglycan. Italso stimulates the formation and secretion of plasminogenactivator by human synovial cells. NAP-2 is a ligand for CXCR1 andCXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and mostpotent NAP-2(1-63) are chemoattractants and activators forneutrophils. TC-1 and TC-2 are antibacterial proteins, in vitroreleased from activated platelet alpha-granules. CTAP-III(1-81) ismore potent than CTAP-III desensitize chemokine-induced neutrophilactivation..
Chemokine(C-X-C motif) ligand 7(CXCL7), also called PPBP or SCYB7, is a human gene. The encoded protein, Chemokine(C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. CXCL7 is mapped to 4q13.3. It is a protein that is released in large amounts from platelets following their activation. CXCL7 is the precursor of the 2 platelet alpha-granule proteins, platelet basic protein(PBP) and connective tissue-activating peptide III(CTAP3). It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
