protein_function: Receptor that mediates the recognition, internalizationand degradation of oxidatively modified low density lipoprotein(oxLDL) by vascular endothelial cells. OxLDL is a marker ofatherosclerosis that induces vascular endothelial cell activationand dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDLinduces the activation of NF-kappa-B through an increasedproduction of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitricoxide (NO) release, monocyte adhesion and apoptosis. In additionto binding oxLDL, it acts as a receptor for the HSP70 proteininvolved in antigen cross-presentation to naive T-cells indendritic cells, thereby participating in cell-mediated antigencross-presentation. Also involved in inflammatory process, byacting as a leukocyte-adhesion molecule at the vascular interfacein endotoxin-induced inflammation. Also acts as a receptor foradvanced glycation end (AGE) products, activated platelets,monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity)..
Oxidized low-density lipoprotein receptor 1(Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1(LOX-1) is a protein that in humans is encoded by the OLR1 gene. It belongs to the C-type lectin superfamily. The LOX1 gene is mapped to to 12p13-p12. The protein has got the amino acids of 363. It can be detected in various tissues, highly expressed in placenta. This protein may be involved in the regulation of Fas-induced apoptosis and play a role as a scavenger receptor. The standards of this kit are recombinant mouse LOX-1(R60-I363), with molecular weight of 36.3kDa.
