protein_function: Converts the abundant, but inactive, zymogen plasminogento plasmin by hydrolyzing a single Arg-Val bond in plasminogen. Bycontrolling plasmin-mediated proteolysis, it plays an importantrole in tissue remodeling and degradation, in cell migration andmany other physiopathological events. Plays a direct role infacilitating neuronal migration.
Plasminogen activator, tissue, also called PLAT or TPA is a serine protease. This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This gene was mapped to 8p11.21. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.