protein_function: Plasmin dissolves the fibrin of blood clots and acts asa proteolytic factor in a variety of other processes includingembryonic development, tissue remodeling, tumor invasion, andinflammation. In ovulation, weakens the walls of the Graafianfollicle. It activates the urokinase-type plasminogen activator,collagenases and several complement zymogens, such as C1 and C5.Cleavage of fibronectin and laminin leads to cell detachment andapoptosis. Also cleaves fibrin, thrombospondin and von Willebrandfactor. Its role in tissue remodeling and tumor invasion may bemodulated by CSPG4. Binds to cells..
Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. It displays increased inhibitory activity(ED????? =70 nM) relative to kringles 1-4(ED????? = 135 nM).
