protein_function: Protein with hypoxia-induced expression in endothelialcells. May act as a regulator of angiogenesis and modulatetumorigenesis. Inhibits proliferation, migration, and tubuleformation of endothelial cells and reduces vascular leakage. Mayexert a protective function on endothelial cells through anendocrine action. It is directly involved in regulating glucosehomeostasis, lipid metabolism, and insulin sensitivity. Inresponse to hypoxia, the unprocessed form of the proteinaccumulates in the subendothelial extracellular matrix (ECM). Thematrix-associated and immobilized unprocessed form limits theformation of actin stress fibers and focal contacts in theadhering endothelial cells and inhibits their adhesion. It alsodecreases motility of endothelial cells and inhibits the sproutingand tube formation (By similarity)..
Angiopoietin-related protein 4(Angptl4) is a protein that in humans is encoded by the ANGPTL4 gene. This gene is a member of the angiopoietin,angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. By radiation hybrid analysis, Angptl4 gene is mapped to 19p13.3. ANGPTL4 contributed to tumor growth and protected cells from anoikis, a form of programmed cell death induced when contact-dependent cells detach from the surrounding tissue matrix.
