protein_function: Monokine with inflammatory and chemokinetic properties.Has chemotactic activity for monocytes, neutrophils, eosinophils,basophils, and lymphocytes. Required for lung TNF-alphaproduction, neutrophil recruitment and subsequent lung injury andmay function as an autocrine mediator for the macrophageproduction of TNF-alpha which in turn up-regulates vascularadhesion molecules required for neutrophil influx. This proteinbinds heparin.
Macrophage inflammatory protein-1 alpha(MIP-1 alpha), also called CCL3, LD78. The cDNA for MIP-1 alpha predicts a mature peptide of 69 amino acids with a molecular mass of 7,889 daltons. LD78 is a member of a newly identified superfamily of small inducible proteins involved in inflammatory responses, wound healing and tumorigenesis. MIP-1 alpha is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. It constitutes an important second signal for mast cell degranulation in the conjunctiva in vivo and consequently for acute-phase disease.
