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Mouse GPNMB,Osteoactivin ELISA Kit

EK5608
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  Catalog No. Package Size Price
EK5608 96T $599.00

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Description
  • Product Name Mouse GPNMB,Osteoactivin ELISA Kit
  • Specificity Mouse
  • Crossing Reactivity There is no detectable cross-reactivity with other relevant proteins.
  • Immunogen Type NSO,K23-N502
  • Alternative Names Transmembrane glycoprotein NMB; DC-HIL; Dendritic cell-associated transmembrane protein; Osteoactivin; Gpnmb; Dchil, Hgfin, Nmb;
  • Accession No. Q99P91
  • Cell Localization Cell membrane; Vesicular, endosomal like structures.
Application Details

sensitivity:10pg ml
Detect Range:156pg ml-10 000pg ml
sample_type:cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA).
capture_antibody:monoclonal antibody from rat
detection_antibody:polyclonal antibody from goat
gene_name:GPNMB
protein_name:Transmembrane glycoprotein NMB
gene_full_name:Transmembrane glycoprotein NMB
tissue_specificity: In early development mRNA is detected at highlevels in the outer layer of the retina. Later in developmentexpression gets restricted to the retinal pigment epithelium andiris. Overexpressed in mammary cancer cells possessing a strongbone metastatic phenotype..
sequence_similarities:Belongs to the PMEL NMB family.
tmb_incubation:20-25min
research_category:immunology|innate immunity|macrophage / inflamm.|cancer|tumor immunology|tumor-associated antigens

Product Description
Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Osteoactivin,GPNMB
Background
protein_function: Could be a melanogenic enzyme..
Transmembrane glycoprotein NMB is a protein that is encoded by the GPNMB gene. In osteoblast progenitor cells, GPNMB works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. GPNMB can enhance the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis(soft callus) and osteogenesis(hard callus) compared to the intact femurs that is why Osteoactivin(OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, GPNMB expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
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