protein_function: Seems to play a role in epithelial tight junctionformation. Appears early in primordial forms of cell junctions andrecruits PARD3. The association of the PARD6-PARD3 complex mayprevent the interaction of PARD3 with JAM1, thereby preventingtight junction assembly (By similarity). Plays a role inregulating monocyte transmigration involved in integrity ofepithelial barrier. Involved in platelet activation. In case oforthoreovirus infection, serves as receptor for the virus..
Junctional adhesion molecule A(JAM-A) is a protein that in humans is encoded by the F11R gene. It is mapped to 1q23.3. This gene is an immunoglobulin-like molecule that colocalizes with tight junctions in endothelium and epithelium and is also found on blood leukocytes and platelets. JAM-A plays an important role in the regulation of tight junction assembly in epithelia. In addition, it can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. JAM-A has a nonredundant role in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity.
