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EK5740 96T $599.00

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  • Product Name Rat TNFSF11,RANKL ELISA Kit
  • Specificity Rat
  • Crossing Reactivity There is no detectable cross-reactivity with other relevant proteins.
  • Alternative Names Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD254; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; Tnfsf11; Opgl, Rankl, Trance;
  • Accession No. Q9ESE2
  • Cell Localization Cell membrane; Single-passtype II membrane protein.
Application Details


Detect Range:15.6pg/ml-1000pg/ml
sample_type:cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA).
protein_name:Tumor necrosis factor ligand superfamily member 11
gene_full_name:Tumor necrosis factor ligand superfamily member 11
tissue_specificity: Highly expressed in thymus and bone tissues.

Product Description

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat TNFSF11,RANKL


protein_function: Cytokine that binds to TNFRSF11B,OPG and toTNFRSF11A,RANK. Osteoclast differentiation and activation factor.Augments the ability of dendritic cells to stimulate naive T-cellproliferation. May be an important regulator of interactionsbetween T-cells and dendritic cells and may play a role in theregulation of the T-cell-dependent immune response. May also playan important role in enhanced bone-resorption in humoralhypercalcemia of malignancy. Induces osteoclastogenesis byactivating multiple signaling pathways in osteoclast precursorcells, chief among which is induction of long lasting oscillationsin the intracellular concentration of Ca (2+) resulting in theactivation of NFATC1, which translocates to the nucleus andinduces osteoclast-specific gene transcription to allowdifferentiation of osteoclasts. During osteoclast differentiation,in a TMEM64 and ATP2A2-dependent manner induces activation ofCREB1 and mitochondrial ROS generation necessary for properosteoclast generation..
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. The rat gene is mapped to 15q11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

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