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Sorafenib

S0093L
Review: comment rank 5 pdf
  Catalog No. Package Size Price
S0093L-1 100mg $57.00
S0093L-2 200mg $77.00

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Description
  • Product Name Sorafenib
  • Brief Description Inhibitors
  • Purification 99.80%
  • Biological Activity Sorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney Y). It has also received "Fast Track" designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver Y), and has since performed well in Phase III trials. Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 & 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.
  • Target Name Raf inhibitor; VEGFR inhibitor
  • CAS No. 284461-73-0
  • Calculated MW 464.83
  • Formulation C21H16ClF3N4O3
  • Storage 3 years -20˚C powder;2 years -80˚C in solvent;
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  • Sorafenib - SAB | Signalway Antibody


Product Description

Research Area:Cancer
SMILES:CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)C=C2)=C1
Pathways:Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
Receptor:B-Raf; B-Raf (V599E); Raf-1; VEGFR2/Flk1; VEGFR3
Boling pt:523.3C
Melting pt:202-204C
Solubility:DMSO: 63 mg/mL warmed (135.53 mM)
Appearance:WhitePowder
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

Regerences

1.Wilhelm SM, et al. Y Res. 2004 Oct 1;64(19):7099-109.

    Please let us know if you have published research using #S0093L so that we can cite your reference.
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