• Product NameDacogen
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityDecitabine is indicated for treatment of patients with myelodysplastic syndrome (MDS). It is a chemical analogue of cytidine, a nucleoside present in DNA and RNA. Cells in the presence of Decitabine incorporate it into DNA during replication and RNA during transcription. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate.
• Target NameDNA Methyltransferase inhibitor
• CAS No. 2353-33-5
• Calculated MW 228.21
• Formulation C8H12N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O
  Pathways:Chromatin/Epigenetic
  Receptor:DNA methyltransferase (DNMT)
  Boling pt:485.8C
  Melting pt:200C
  Solubility:Water: 10 mg/mL (43.81 mM); DMSO: 45 mg/mL (197.18 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shaker S, et al. Leuk Res, 2003, 27(5), 437-444.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting