• Product NameSGI-1776 free base
• Brief DescriptionInhibitors
• Purification99.30%
• Biological ActivitySGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
• Target NameFLT inhibitor; Pim inhibitor
• CAS No. 1025065-69-3
• Calculated MW 405.42
• Formulation C20H22F3N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCC(CNC2=NN3C(C=C2)=NC=C3C2=CC(OC(F)(F)F)=CC=C2)CC1
  Pathways:Chromatin/Epigenetic; Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:FLT3; Pim1; Pim2; Pim3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 81 mg/mL (199.79 mM); DMSO: 81 mg/mL (199.79 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chen LS, et al. Blood, 2011, 118(3), 693-702.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting