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Nepicastat (SYN-117) HCl

S6604
Review: comment rank 5 pdf
  Catalog No. Package Size Price
S6604-1 2mg $57.00
S6604-2 5mg $91.00
S6604-3 10mg $160.00
S6604-4 25mg $376.00
S6604-5 50mg $721.00

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Description
  • Product Name Nepicastat (SYN-117) HCl
  • Brief Description Inhibitors
  • Purification 98.74%
  • Biological Activity Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.
  • Target Name Hydroxylase inhibitor
  • CAS No. 170151-24-3
  • Calculated MW 331.81
  • Formulation C14H15F2N3SHCl
  • Storage 3 years -20˚C powder;2 years -80˚C in solvent;
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  • Nepicastat (SYN-117) HCl - SAB | Signalway Antibody


Product Description
Research Area:Nervous system
SMILES:C1CC2=C(C=C(C=C2C[C@H]1N3C(=CNC3=S)CN)F)F.Cl
Pathways:Metabolism
Receptor:Dopamine β-hydroxylase; Dopamine β-hydroxylase
Boling pt:
Melting pt:
Solubility:DMSO:66 mg/mL (198.9 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
Appearance:
Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.
Regerences
1. Stanley WC, et al. Br J Pharmacol. 1997, 121(8), 1803-1809.
    Please let us know if you have published research using #S6604 so that we can cite your reference.
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