• Product NamePamapimod (R-1503, Ro4402257)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.0140.002 and 0.48 0.04 microM, respectively with no activity against p38delta or p38gamma isoforms.
• Target Namep38 MAPK inhibitor
• CAS No. 449811-01-2
• Calculated MW 406.38
• Formulation C19H20F2N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC(CCO)CCO
  Pathways:MAPK
  Receptor:p38α; p38β
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 28 mg/mL (68.9 mM) DMSO: 81 mg/mL (199.32 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hill RJ, et al. J Pharmacol Exp Ther. 2008, 327(3):610-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting