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CCDC111 Antibody

48105
Review: comment rank 5 pdf
  Catalog No. Package Size Price
48105-1 50ul $260.00
48105-2 100ul $390.00

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Description
  • Product Name CCDC111 Antibody
  • Host Species Mouse
  • Clonality Monoclonal
  • Clone No. 10-B3
  • Purification ProG affinity purified
  • Applications ICC, IHC
  • Species Reactivity Hu
  • Immunogen Description recombinant protein
  • Alternative Names CC111_HUMAN antibody
    CCDC111 antibody
    Coiled coil domain containing 111 antibody
    Coiled-coil domain-containing protein 111 antibody
    DNA-directed primase/polymerase protein antibody
    MYP22 antibody
    Primase and polymerase (DNA directed) antibody
    PRIMPOL antibody
  • Accession No. Swiss-Prot#:Q96LW4
  • Calculated MW 64kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details


IHC: 1:200
ICC: 1:100-1:200

Images
  • CCDC111 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human colonic tissue using anti- CCDC111 mouse monoclonal antibody.

  • CCDC111 Antibody - SAB | Signalway Antibody

    ICC staining CCDC111 in HepG2 cells(red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Background
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. PRIMPOL shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. It is involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. PRIMPOL is required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. PRIMPOL has non-overlapping function with POLH.
Regerences
1."hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity." Wan L., Lou J., Xia Y., Su B., Liu T., Cui J., Sun Y., Lou H., Huang J. EMBO Rep. 14:1104-1112(2013)
2."PrimPol, an archaic primase/polymerase operating in human cells." Garcia-Gomez S., Reyes A., Martinez-Jimenez M.I., Chocron E.S., Mouron S., Terrados G., Powell C., Salido E., Mendez J., Holt I.J., Blanco L. Mol. Cell 52:541-553(2013)
3."PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication." Bianchi J., Rudd S.G., Jozwiakowski S.K., Bailey L.J., Soura V., Taylor E., Stevanovic I., Green A.J., Stracker T.H., Lindsay H.D., Doherty A.J. Mol. Cell 52:566-573(2013)
    Please let us know if you have published research using #48105 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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