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Caspase-9 Antibody

48687
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  Catalog No. Package Size Price
48687-1 50ul $260.00
48687-2 100ul $390.00

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Description
  • Product Name Caspase-9 Antibody
  • Clone No. SZ29-01
  • Purification ProA affinity purified
  • Applications WB, ICC/IF, IHC, IP
  • Species Reactivity Hu, Ms
  • Immunogen Description recombinant protein
  • Alternative Names APAF-3 antibody
    APAF3 antibody
    Apoptosis related cysteine peptidase antibody
    Apoptotic protease Mch-6 antibody
    Apoptotic protease-activating factor 3 antibody
    CASP-9 antibody
    CASP9 antibody
    CASP9_HUMAN antibody
    Caspase 9 apoptosis related cysteine peptidase antibody
    Caspase 9 Dominant Negative antibody
    Caspase 9c antibody
    Caspase-9 antibody
    Caspase-9 subunit p10 antibody
    ICE LAP6 antibody
    ICE like apoptotic protease 6 antibody
    ICE-LAP6 antibody
    ICE-like apoptotic protease 6 antibody
    MCH6 antibody
    PPP1R56 antibody
    protein phosphatase 1, regulatory subunit 56 antibody
    RNCASP9 antibody
  • Accession No. Swiss-Prot#:P55211
  • Calculated MW 46/35 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:100-1:500

Images
  • Caspase-9 Antibody - SAB | Signalway Antibody

    ICC staining Caspase-9 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Caspase-9 Antibody - SAB | Signalway Antibody

    ICC staining Caspase-9 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Caspase-9 Antibody - SAB | Signalway Antibody

    ICC staining Caspase-9 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Caspase-9 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Caspase-9 antibody. Counter stained with hematoxylin.

  • Caspase-9 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-Caspase-9 antibody. Counter stained with hematoxylin.

  • Caspase-9 Antibody - SAB | Signalway Antibody

    Western blot analysis of Caspase-9 on different lysates using anti-Caspase-9 antibody at 1/1,000 dilution. Positive control:
    Lane 1: Jurkat
    Lane 2: Hela
    Lane 3: C2C12

Background

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins, which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.

Regerences

1. Arango-Gonzalez B et al. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PLoS One 9:e112142 (2014).
2. Schattenberg JM et al. Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP. Am J Physiol Gastrointest Liver Physiol 303:G498-506 (2012).

    Please let us know if you have published research using #48687 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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