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Cardiac Troponin T Antibody

48966
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  Catalog No. Package Size Price
48966-1 50ul $260.00
48966-2 100ul $390.00

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Description
  • Product Name Cardiac Troponin T Antibody
  • Host Species Rabbit
  • Clonality Monoclonal
  • Clone No. SC64-03
  • Purification ProA affinity purified
  • Applications WB, IHC
  • Species Reactivity Hu, Ms, Rt
  • Immunogen Description recombinant protein
  • Alternative Names Cardiac muscle troponin T antibody
    Cardiomyopathy dilated 1D (autosomal dominant) antibody
    Cardiomyopathy hypertrophic 2 antibody
    CMD1D antibody
    CMH2 antibody
    CMPD2 antibody
    cTnT antibody
    LVNC6 antibody
    MGC3889 antibody
    OTTHUMP00000033864 antibody
    OTTHUMP00000033865 antibody
    OTTHUMP00000033866 antibody
    OTTHUMP00000033867 antibody
    OTTHUMP00000033870 antibody
    OTTHUMP00000218095 antibody
    RCM3 antibody
    TNNT 2 antibody
    TNNT2 antibody
    TNNT2_HUMAN antibody
    TnTc antibody
    Troponin T cardiac muscle antibody
    Troponin T type 2 (cardiac) antibody
    Troponin T type 2 cardiac antibody
    Troponin T, cardiac muscle antibody
    Troponin T2 cardiac antibody
  • Accession No. Swiss-Prot#:P45379
  • Calculated MW 36 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:1,000-1:2,000
IHC: 1:100-1:500


Images
  • Cardiac Troponin T Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-Cardiac Troponin T antibody. Counter stained with hematoxylin.

Background
Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Myosin is a hexamer of two heavy chains (MHC) and four light chains (MLC) that interacts with Actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. Troponin facilitates the interaction between Actin and Myosin by binding to calcium. Troponin is made up of at least two subunits, which are divergent in cardiac muscle, fast skeletal muscle and slow skeletal muscle. Structures of skeletal muscle troponin are composed of Troponin C (the sensor), Troponin I (the regulator) and Troponin T (the link to the muscle thin filament). Troponin C is dumbbell-shaped and has a hydrophobic pocket that increases the contractile force of muscle fibers. Troponin C has two isoforms: fast and slow. Fast Troponin C has two calcium binding sites, while slow/cardiac Troponin C has a single calcium binding site.
Regerences
1. Szebnyi K et al. Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling. Sci Rep 5:12645 (2015).
2. Becker JR et al. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141:335-45 (2014).
    Please let us know if you have published research using #48966 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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