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NLRP3 Antibody

49012
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  Catalog No. Package Size Price
49012-1 50ul $260.00
49012-2 100ul $390.00

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Description
  • Product Name NLRP3 Antibody
  • Clone No. SC06-23
  • Purification ProA affinity purified
  • Applications WB, ICC/IF, IHC, IP, FC
  • Species Reactivity Hu, Ms, Rt
  • Immunogen Description recombinant protein
  • Alternative Names AGTAVPRL antibody
    AII/AVP antibody
    Angiotensin/vasopressin receptor AII/AVP like antibody
    Angiotensin/vasopressin receptor AII/AVP-like antibody
    C1orf7 antibody
    Caterpiller protein 1.1 antibody
    CIAS 1 antibody
    CIAS1 antibody
    CLR1.1 antibody
    Cold autoinflammatory syndrome 1 antibody
    Cold autoinflammatory syndrome 1 protein antibody
    Cryopyrin antibody
    Familial cold autoinflammatory syndrome antibody
    FCAS antibody
    FCU antibody
    LRR and PYD domains-containing protein 3 antibody
    Muckle-Wells syndrome antibody
    MWS antibody
    NACHT antibody
    NACHT LRR and PYD containing protein 3 antibody
    NALP 3 antibody
    NALP3 antibody
    NALP3_HUMAN antibody
    NLRP3 antibody
    PYPAF 1 antibody
    PYPAF1 antibody
    PYRIN containing APAF1 like protein 1 antibody
    PYRIN-containing APAF1-like protein 1 antibody
  • Accession No. Swiss-Prot#:Q96P20
  • Calculated MW 118/85 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:100-1:500

FC: 1:50-1:100

Images
  • NLRP3 Antibody - SAB | Signalway Antibody

    Flow cytometric analysis of Jurkat cells with NLRP3 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.

  • NLRP3 Antibody - SAB | Signalway Antibody

    ICC staining NLRP3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • NLRP3 Antibody - SAB | Signalway Antibody

    ICC staining NLRP3 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • NLRP3 Antibody - SAB | Signalway Antibody

    ICC staining NLRP3 in PMVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • NLRP3 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse bladder tissue using anti- NLRP3 antibody. Counter stained with hematoxylin.

  • NLRP3 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- NLRP3 antibody. Counter stained with hematoxylin.

Background

Cryopyrin interacts selectively with apoptosis-associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Regerences

1. Qiao J et al. Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation. Sci Rep 5:17828 (2015).
2. Ataide MA et al. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog 10:e1003885 (2014).

    Please let us know if you have published research using #49012 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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