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P Glycoprotein Antibody

49042
Review: comment rank 5 pdf
  Catalog No. Package Size Price
49042-1 50ul $260.00
49042-2 100ul $390.00

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Description
  • Product Name P Glycoprotein Antibody
  • Clone No. SN06-42
  • Purification ProA affinity purified
  • Applications WB, IHC
  • Species Reactivity Hu, Ms, Rt
  • Immunogen Description recombinant protein
  • Alternative Names ABC20 antibody
    ABCB1 antibody
    ATP binding cassette, sub family B (MDR/TAP), member 1 antibody
    ATP-binding cassette sub-family B member 1 antibody
    CD243 antibody
    CLCS antibody
    Colchicin sensitivity antibody
    Doxorubicin resistance antibody
    GP170 antibody
    MDR1 antibody
    MDR1_HUMAN antibody
    Multidrug resistance 1 antibody
    Multidrug resistance protein 1 antibody
    P glycoprotein 1 antibody
    P gp antibody
    P-glycoprotein 1 antibody
    PGY1 antibody
  • Accession No. Swiss-Prot#:P08183
  • Calculated MW 180 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

WB: 1:1,000
IHC: 1:50-1:200
 

Images
  • P Glycoprotein Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-P Glycoprotein antibody. Counter stained with hematoxylin.

  • P Glycoprotein Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-P Glycoprotein antibody. Counter stained with hematoxylin.

  • P Glycoprotein Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-P Glycoprotein antibody. Counter stained with hematoxylin.

Background

Cells selected for resistance to a single cytotoxic drug may become cross-resistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). The MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of MDR is associated with an increase in the Mdr protein, but not all cases of MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. In the human population, there are 15 polymorphisms in the Mdr-1 gene.

Regerences

1. St George M et al. Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells. PLoS One 10:e0129168 (2015).
2. Majek P et al. Proteome changes in the plasma of myelodysplastic syndrome patients with refractory anemia with excess blasts subtype 2. Dis Markers 2014:178709 (2014).

    Please let us know if you have published research using #49042 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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