• Product NameIL1F10 Monoclonal Antibody
• Host SpeciesMouse
• ClonalityMonoclonal
• Purificationprotein G purifed
• ApplicationsIHC
• Species ReactivityHu
• Specificityspecific for Human IL1F10 denatured and native forms
• Immunogen DescriptionRecombinant Human IL1F10 protein
• Target NameIL1F10
• Alternative Names    IL-1F10, Family of interleukin 1-theta, FIL1 theta Interleukin-1 HY2, IL-1HY2, Interleukin-1 theta, IL-1 theta Interleukin-38, IL-38
• Accession No. Swiss-Prot#: Q8WWZ1
• UniprotQ8WWZ1
• Gene ID84639;
• Concentration 3.12mg/ml
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.

"IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist." van de Veerdonk F.L., Stoeckman A.K., Wu G., Boeckermann A.N., Azam T., Netea M.G., Joosten L.A., van der Meer J.W., Hao R., Kalabokis V., Dinarello C.A. Proc. Natl. Acad. Sci. U.S.A. 109:3001-3005(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

• Immunohistochemical analysis of paraffin-embedded Human Colon cancer tissue using #42049 at dilution of 1:200.
• Immunohistochemical analysis of paraffin-embedded Human live cancer tissue using #42049 at dilution of 1:200.
• Immunohistochemical analysis of paraffin-embedded Human spleen tissue using #42049 at dilution of 1:200.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting