Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
[1]Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer."Shridhar V., Rivard S., Wang X., Shridhar R., Paisley C., Mullins C., Beirnat L., Dugan M., Sarkar F., Miller O.J., Vaitkevicius V.K., Smith D.I.Oncogene 14:2213-2216(1997). [2]Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck."Shridhar R., Shridhar V., Rivard S., Siegfried J.M., Pietraszkiewicz H., Ensley J., Pauley R., Grignon D., Sakr W., Miller O.J., Smith D.I.Cancer Res. 56:5576-5578(1996). [3]The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional." Parkash V., Lindholm P., Peranen J., Kalkkinen N., Oksanen E., Saarma M., Leppanen V.-M., Goldman A. Protein Eng. Des. Sel. 22:233-241(2009).
