• Product NameBeta-adrenergic receptor kinase 1 Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Beta-adrenergic receptor kinase 1 polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Beta-adrenergic receptor kinase 1 protein
• Target NameBeta-adrenergic receptor kinase 1
• Alternative Names    G-protein coupled receptor kinase 2, ADRBK1, BARK, BARK1, GRK2
• Accession No. Swiss-Prot#: P25098
• UniprotP25098
• Gene ID156;
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

[1] cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.Benovic J.L., Stone W.C., Huebner K., Croce C., Caron M.G., Lefkowitz R.J.FEBS Lett. 283:122-126(1991) [2] High expression of beta-adrenergic receptor kinase in

• Immunohistochemical analysis of paraffin-embedded human prostate using #42189 at dilution of 1:20.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting