Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
[1]Interaction with podocin facilitates nephrin signaling. Huber T.B., Kottgen M., Schilling B., Walz G., Benzing T. J. Biol. Chem. 276:41543-41546(2001). [2]Phosphoproteome of resting human platelets. Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008). [3]A familial childhood-onset relapsing nephrotic syndrome. Kitamura A., Tsukaguchi H., Hiramoto R., Shono A., Doi T., Kagami S., Iijima K. Kidney Int. 71:946-951(2007).
