Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
[1]Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase.Song I., Chuang C.Z., Bateman R.C. Jr.J. Mol. Endocrinol. 13:77-86(1994)[2]Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Su
