• Product NameTyrosinase Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Tyrosinase polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Tyrosinase protein£¨19-377aa£©
• Target NameTyrosinase
• Alternative Names    LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB, TYR
• Accession No. Swiss-Prot#: P14679
• UniprotP14679
• Gene ID7299;
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.

[1]"Characteristic sequences in the upstream region of the human tyrosinase gene." Kikuchi H., Miura H., Yamamoto H., Takeuchi T., Dei T., Watanabe M. Biochim. Biophys. Acta 1009:283-286(1989). [2]"Molecular phylogenetics and the origins of placental mammals." Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.-P., Ryder O.A., O'Brien S.J. Nature 409:614-618(2001). [3]"A genomewide association study of skin pigmentation in a South Asian population." Stokowski R.P., Pant P.V.K., Dadd T., Fereday A., Hinds D.A., Jarman C., Filsell W., Ginger R.S., Green M.R., van der Ouderaa F.J., Cox D.R. Am. J. Hum. Genet. 81:1119-1132(2007) .

• Immunohistochemical analysis of paraffin-embedded human skin using #42361 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting