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PRKAR2A Antibody

43522
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  Catalog No. Package Size Price
43522 100ul $279.00

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Description
  • Product Name PRKAR2A Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antigen affinity purification
  • Applications IHC WB
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous levels of total PRKAR2A protein.
  • Immunogen Type protein
  • Immunogen Description Fusion protein of human PRKAR2A
  • Target Name PRKAR2A
  • Alternative Names PKR2; PRKAR2
  • Accession No. Swiss-Prot#: P13861
    NCBI Gene ID: 5576
  • Calculated MW 46kd
  • Concentration 1.3mg/ml
  • Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage Store at -20˚C
Application Details

Western blotting: 1:500-2000
Immunohistochemistry: 1: 100-200

Images
  • PRKAR2A Antibody - SAB | Signalway Antibody

    Gel: 8%SDS-PAGE
    Lysate: 40 μg, Lane 1-2: HEPG2 cell and Human testis tissue lysates,
    Primary antibody:PRKAR2A antibody at dilution 1/550,
    Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
    Exposure time: 30 seconds

  • PRKAR2A Antibody - SAB | Signalway Antibody

    The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PRKAR2A Antibody at dilution 1/100, on the right is treated with fusion protein. (Original magnification: x200)

  • PRKAR2A Antibody - SAB | Signalway Antibody

    The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PRKAR2A Antibody at dilution 1/100, on the right is treated with fusion protein. (Original magnification: x200)

Background
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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