• Product NameSIN3B Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total SIN3B protein.
• Immunogen Typepeptide
• Immunogen DescriptionSynthetic peptide of human SIN3B
• Target NameSIN3B
• Accession No. Swiss-Prot#: O75182
  NCBI Gene ID: 23309
• UniprotO75182
• Gene ID23309;
• Concentration 0.7mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1: 20-100

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).

• The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using SIN3B Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200)

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting