- Product NameChromatin modification compound library
- Brief DescriptionChromatin modification, also called Chromatin remodeling, is the rearrangement of chromatin from a condensed state to a transcriptionally accessible state, allowing transcription factors or other DNA binding proteins to access DNA and control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, e.g., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes. Chromatin remodeling is highly implicated in epigenetics.Epigenetic modifications to histone proteins such as methylation/demethylation and acetylation/deacetylation can alter the structure of chromatin resulting in transcriptional activation or repression. Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer. Targeting chromatin remodeling pathways is currently evolving as a major therapeutic strategy in the treatment of several cancers. Chromatin Modification Compound Library from SAB is a unique collection of 192 compounds targeting chromatin remodeling pathways that can be used for high throughput and high content screening
- Storage Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcodeShipped with dry ice; Stable for One year as powder, 6 months at - 20 ˚ C in DMSO or 12months at -80 ˚ C in DMSO
