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MEP1B Polyclonal Antibody

27286
Review: comment rank 5 pdf
  Catalog No. Package Size Price
27286-1 50ul $189.00
27286-2 100ul $279.00

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Description
  • Product Name MEP1B Polyclonal Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purification Affinity purification
  • Applications WB
  • Species Reactivity Ms
  • Immunogen Description Recombinant fusion protein of human MEP1B (NP_005916.2).
  • Alternative Names MEP1B; meprin A subunit beta
  • Accession No. Swiss-Prot#:Q16820
    NCBI Gene ID:4225
  • Calculated MW 105kDa
  • Formulation Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
  • Storage Store at -20˚C
Application Details

WB 1:500 - 1:1000

Images
  • MEP1B Polyclonal Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts of mouse kidney, using MEP1B antibody.

Background
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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