• Product NameD2HGDH Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• IsotypeIgG
• PurificationAffinity purification
• ApplicationsWB
• Species ReactivityMouse,Rat
• Immunogen DescriptionRecombinant fusion protein of human D2HGDH (NP_689996.4).
• Alternative Names    D2HGDH; D2HGD; D-2-hydroxyglutarate dehydrogenase
• Accession No. Swiss-Prot#:Q8N465
  NCBI Gene ID:728294
• UniprotQ8N465
• Gene ID728294;
• Calculated MW 56kDa
• Formulation Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
• Storage Store at -20˚C

• WB 1:500 - 1:2000

This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.

• Western blot analysis of extracts of various cell lines, using D2HGDH at 1:1000 dilution.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting