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Recombinant Human ACE-2 (C-Fc)

AP89518
Review: comment rank 5 pdf
  Catalog No. Package Size Price
AP89518-1 10ug $219.00
AP89518-2 50ug $656.00
AP89518-3 500ug $3250.00
AP89518-4 1mg $4875.00

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Description
  • Product Name Recombinant Human ACE-2 (C-Fc)
  • Brief Description Recombinant Proteins
  • Purification Greater than 95% as determined by reducing SDS-PAGE.
  • Biological Activity Immobilized Human ACE-2-FC at 10μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-SD1-mFc. The ED50 of Recombinant 2019-nCoV S Protein RBD-mFc is 15.5 ng/ml .
  • Alternative Names Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
  • Accession No. Uniprot ID: Q9BYF1
  • Storage Store at < -20˚C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
Application Details

Expression Region: Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a Fc tag at the C-terminus.

Relevance: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

Storage Buffer: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.

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