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PRKACA Antibody

46647
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  Catalog No. Package Size Price
46647 100ul $279.00

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Description
  • Product Name PRKACA Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antigen affinity purification
  • Applications WB IHC
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous levels of total PRKACA protein.
  • Immunogen Type peptide
  • Immunogen Description Synthetic peptide corresponding to residues near the C terminal of human PRKACA
  • Target Name PRKACA
  • Alternative Names PKACA; PPNAD4
  • Accession No. Swiss-Prot:P17612
    NCBI Gene ID:5566
    NCBI Protein:NP_002721
  • Calculated MW 41 kDa
  • Concentration 0.8mg/ml
  • Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage Store at -20˚C
Application Details

Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 25-100

Images
  • PRKACA Antibody - SAB | Signalway Antibody

    Gel: 8%SDS-PAGE
    lysate: 40 ¦Ìg, Lane: Human testis tissue lysate,
    Primary antibody: 46647£¨PRKACA Antibody) at dilution 1/250
    Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
    Exposure time: 3 seconds

  • PRKACA Antibody - SAB | Signalway Antibody

    The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46647(PRKACA Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200)

  • PRKACA Antibody - SAB | Signalway Antibody

    The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using 46647(PRKACA Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200)

Background
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.
    Please let us know if you have published research using #46647 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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