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mTOR(Phospho-Ser2448) Antibody #11221

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
Availability:Yes
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Description
  • Product NamemTOR(Phospho-Ser2448) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB IHC IF
  • Species ReactivityHu
  • SpecificityThe antibody detects endogenous level of mTOR only when phosphorylated at serine 2448.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of serine 2448 (T-D-S(p)-Y-S) derived from Human mTOR.
  • Target NamemTOR
  • ModificationPhospho
  • Alternative Names    FRAP; FRAP1; FRAP2; RAFT1;
  • Uniprot P42345
  • Gene ID 2475;
  • Accession No. Swiss-Prot: P42345
    NCBI Protein: NP_004949.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

Immunohistochemical assessment of growth factor signaling molecules: MAPK, Akt, and STAT3 pathways in oral epithelial precursor lesions and squamous cell carcinoma.In Odontology on 2020 Jan; by Tashiro K, Oikawa M, et al..PMID: 31062130, , (2020),
PMID: 31062130
Amlexanox Enhances Temozolomide-Induced Antitumor Effects in Human Glioblastoma Cells by Inhibiting IKBKE and the Akt-mTOR Signaling Pathway. In ACS Omega on 2021 Feb 5 by Jinbiao Xiong, Gaochao Guo, et al..PMID:33644550, , (2020),
PMID: 33644550
Immunohistochemical assessment of growth factor signalIng molecules: MAPK, Akt, and STAT3 pathways In oral epithelial precursor lesions and squamous cell carcInoma. In Odontology on 2019 May 6 by Tashiro K, Oikawa M, et al..PMID:31062130, , (2019),
PMID: 31062130
5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats.In Obes Res Clin Pract. On 2018 Jan - Feb by Li X, Guo K et al..PMID: 27133527, , (2018),
PMID: 27133527
View All Published Papers Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.In Mediators Inflamm.On 2018 Sep by Yang Y, Sun Y et al..PMID:30356420, , (2018),
PMID: 30356420
Tunneling Nanotubes Promote Intercellular Mitochondria Transfer Followed by Increased Invasiveness in Bladder Cancer Cells.In Oncotarget on 2017 Feb 28 by Jinjin Lu, Xiufen Zheng,et al..PMID: 28107184, , (2017),
PMID: 28107184
Propranolol Sensitizes Thyroid Cancer Cells to Cytotoxic Effect of Vemurafenib.In Oncol Rep on 2016 Sep by Wei-Jun Wei , Chen-Tian Shen et al..PMID:27432558, , (2016),
PMID: 27432558
TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway.In Cancer Biol Ther on 2016 Jul 2 by Yu Gan , Yong Wang et al..PMID:27104982, , (2016),
PMID: 27104982
Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver.In Int J Biol Sci on 2016 Jan 1 by Jihua Fu , Shaoxin Ma et al..PMID: 26884719, , (2016),
PMID: 26884719
H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway.In Oncotarget on 2016 Dec 20 by Shanmin Zhao, Li Li et al..PMID:27863375, , (2016),
PMID: 27863375
Effective treatment with combination of peripheral 5‐hydroxytryptamine synthetic inhibitor and 5‐hydroxytryptamine 2 receptor antagonist on glucocorticoid‐induced whole‐body insulin resistance with hyperglycemia.In J Diabetes Investig on 2016 Nov by Shaoxin Ma , Tao Li et al..PMID:27177506, , (2016),
PMID: 27177506
Macias M, Blazejczyk M, Kazmierska P Spatiotemporal Characterization of mTOR Kinase Activity Following Kainic Acid Induced Status Epilepticus and Analysis of Rat Brain Response to Chronic Rapamycin Treatment. , PLoS ONE, 8(5): e64455. doi:10.1371/journal.pone.0064455 (2013),
PMID: 23724051
5-Aza-2'-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching.In Arch Toxicol on 2013 May by Ning Y, Huang H,et al..PMID: 23423710, , (2013),
PMID: 23423710
Spatiotemporal Characterization of mTOR Kinase Activity Following Kainic Acid Induced Status Epilepticus and Analysis of Rat Brain Response to Chronic Rapamycin Treatment. In PLoS One on 2013 May 28 by Matylda Macias, Magdalena Blazejczyk, et al..PMID: 23724051, , (2013),
PMID: 23724051
Please let us know if you have published research using #11221 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep